IL-4 and IL-6 Production of Bone Marrow-Derived Mast Cells Is Enhanced by Treatment with Environmental Pollutants

1997 ◽  
Vol 114 (3) ◽  
pp. 237-245 ◽  
Author(s):  
K. Saneyoshi ◽  
O. Nohara ◽  
T. Imai ◽  
F. Shiraishi ◽  
H. Moriyama ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mast Cells ◽  
Environmental Pollutants

Isolation and Culture of Bone Marrow-derived Mast Cells

BIO-PROTOCOL ◽  
2014 ◽  
Vol 4 (4) ◽  
Author(s):  
Krisztina Vukman ◽  
Martin Metz ◽  
Marcus Maurer ◽  
Sandra O’Neill
Keyword(s):  
Bone Marrow ◽  
Mast Cells

Regulation of proliferation of mouse bone marrow-derived mast cells by activated fibroblasts

1996 ◽  
Vol 19 (5) ◽  
pp. 368-373
Author(s):  
Sung-Joo Park ◽  
Hyung-Ryong Kim ◽  
Hye-Won Cho ◽  
Hyung-Min Kim
Keyword(s):  
Bone Marrow ◽  
Mast Cells ◽  
Mouse Bone Marrow ◽  
Regulation Of Proliferation ◽  
Activated Fibroblasts

scholarly journals The antigen presentation function of bone marrow-derived mast cells is spatiotemporally restricted to a subset expressing high levels of cell surface FcεRI and MHC II

2010 ◽  
Vol 11 (1) ◽  
pp. 34 ◽  
Author(s):  
Jian Gong ◽  
Ning-Sun Yang ◽  
Michael Croft ◽  
I-Chun Weng ◽  
Liangwu Sun ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mast Cells ◽  
Cell Surface ◽  
Antigen Presentation ◽  
Mhc Ii

Inhibitory effects of Piper betle on production of allergic mediators by bone marrow-derived mast cells and lung epithelial cells

2008 ◽  
Vol 8 (3) ◽  
pp. 453-457 ◽  
Author(s):  
Mali Wirotesangthong ◽  
Naoki Inagaki ◽  
Hiroyuki Tanaka ◽  
Witchuda Thanakijcharoenpath ◽  
Hiroichi Nagai
Keyword(s):  
Bone Marrow ◽  
Mast Cells ◽  
Epithelial Cells ◽  
Lung Epithelial Cells ◽  
Piper Betle ◽  
Inhibitory Effects ◽  
Lung Epithelial

Development of mast cells from grafted bone marrow cells in irradiated mice

Nature ◽  
1977 ◽  
Vol 268 (5619) ◽  
pp. 442-443 ◽  
Author(s):  
Y. KITAMURA ◽  
M. SHIMADA ◽  
K. HATANAKA ◽  
Y. MIYANO
Keyword(s):  
Bone Marrow ◽  
Mast Cells ◽  
Bone Marrow Cells ◽  
Marrow Cells

scholarly journals The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase.

1995 ◽  
Vol 182 (1) ◽  
pp. 197-206 ◽  
Author(s):  
M Murakami ◽  
K F Austen ◽  
J P Arm
Keyword(s):  
Bone Marrow ◽  
Arachidonic Acid ◽  
Mast Cells ◽  
Cell Membrane ◽  
Phospholipase A2 ◽  
Mouse Bone Marrow ◽  
Kit Ligand ◽  
Cytosolic Phospholipase ◽  
Delayed Phase ◽  
Stimulation Of

c-kit ligand (KL) activated mouse bone marrow-derived mast cells (BMMC) for the dose- and time-dependent release of arachidonic acid from cell membrane phospholipids, with generation of leukotriene (LT) C4 in preference to prostaglandin (PG)D2. KL at concentrations of 10 ng/ml elicited half-maximal eicosanoid generation and at concentrations of > 50 ng/ml elicited a maximal generation of approximately 15 ng LTC4 and 1 ng PGD2 per 10(6) cells, with 20% net beta-hexosaminidase release 10 min after stimulation. Of the other cytokines tested, none, either alone or in combination with KL, elicited or modulated the immediate phase of mediator release by BMMC, indicating strict specificity for KL. Activation of BMMC in response to KL was accompanied by transient phosphorylation of cytosolic phospholipase A2 and reversible translocation of 5-lipoxygenase to a cell membrane fraction 2-5 min after stimulation, when the rate of arachidonic acid release and LTC4 production were maximal. BMMC continuously exposed to KL in the presence of IL-10 and IL-1 beta generated LTC4 in marked preference to PGD2 over the first 10 min followed by delayed generation of PGD2 with no LTC4 over several hours. Pharmacologic studies revealed that PGD2 generation in the immediate phase depended on prostaglandin endoperoxide synthase (PGHS)-1 and in the delayed phase on PGHS-2. Thus, KL provided a nonallergic stimulus for biphasic eicosanoid generation by mast cells. The immediate phase is dominated by LTC4 generation with kinetics and postreceptor biosynthetic events similar to those observed after cell activation through the high affinity IgE receptor, whereas the delayed phase of slow and selective PGD2 production is mediated by induction of PGHS-2.

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