Streptococcal Erythrogenic Toxins Induce Tryptophan Degradation in Human Peripheral Blood Mononuclear Cells

1997 ◽  
Vol 114 (3) ◽  
pp. 224-228 ◽  
Author(s):  
Christian Murr ◽  
Bernard Widner ◽  
Dieter Gerlach ◽  
Gabriele Werner-Felmayer ◽  
Manfred P. Dierich ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Tryptophan Degradation ◽  
Blood Mononuclear Cells

A Herbal Multicomponent Mixture Effective in Suppressing Biochemical Pathways in Mitogen-stimulated Human Peripheral Blood Mononuclear Cells

Pteridines ◽  
2005 ◽  
Vol 16 (4) ◽  
pp. 195-201
Author(s):  
Gabriele Neurauter ◽  
Barbara Wirleitner ◽  
Harald Schennach ◽  
Florian Ueberall ◽  
Dietmar Fuchs
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Multicomponent Mixture ◽  
Herbal Remedy ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Tryptophan Degradation ◽  
Blood Mononuclear Cells ◽  
Padma 28

Abstract Extract of traditional Tibetan herbal remedy Padma 28 revealed suppressive effects on neopterin production and tryptophan degradation in mitogen-stimulated peripheral blood mononuclear cells (PBMC). One of the questions was to asses the robustness of the Tibetan way of formulating herbal multicomponent medicines. Can small changes affect the effectiveness of the formula? In this study, effect of a derivative multicomponent mixture was investigated in stimulated and unstimulated human PBMC in vitro. Neopterin production and tryptophan degradation were measured in supernatants of PBMC in the presence or absence of mitogens phytohacmagglutinin and concanavalin A. Stimulation of PBMC induced neopterin formation and tryptophan degradation, and the herbal multicomponent mixture inhibited both immunobiochemical effects in a dose-dependent way. Higher concentrations were more effective and were able to completely block the pathways induccd upon mitogenic stimulation. When comparing the results obtained with those observed earlier using Padma 28, there was no obvious difference between the two different preparations. Data allow to conclude that Padma 28 and its modified version is equally able to suppress immunobiological effects in stimulated PBMC.

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