N-Terminus of a Major Allergen, Alt a I, of Alternaria alternata Defined to Be an Epitope

1995 ◽  
Vol 108 (3) ◽  
pp. 254-259 ◽  
Author(s):  
Lei Zhang ◽  
Ivan H.A. Curran ◽  
Gauri Muradia ◽  
Michael W. De Vouge ◽  
Harold Rode ◽  
...  
Keyword(s):  
Alternaria Alternata ◽  
Major Allergen ◽  
N Terminus

Production profile of the major allergen Alt a 1 in Alternaria alternata cultures

2004 ◽  
Vol 93 (6) ◽  
pp. 589-593 ◽  
Author(s):  
Ignacio Ibarrola ◽  
María Suárez-Cervera ◽  
M. Carmen Arilla ◽  
Alberto Martínez ◽  
Javier Monteseirín ◽  
...  
Keyword(s):  
Alternaria Alternata ◽  
Major Allergen

The major allergen of Alternaria alternata (Alt a 1) is expressed in other members of the Pleosporaceae family

Mycoses ◽  
2006 ◽  
Vol 49 (2) ◽  
pp. 91-95 ◽  
Author(s):  
M. Saenz-de-Santamaria ◽  
I. Postigo ◽  
A. Gutierrez-Rodriguez ◽  
G. Cardona ◽  
J. A. Guisantes ◽  
...  
Keyword(s):  
Alternaria Alternata ◽  
Major Allergen

scholarly journals Changes in the Sensitization Pattern to Alternaria alternata Allergens in Patients Treated with Alt a 1 Immunotherapy

2021 ◽  
Vol 7 (11) ◽  
pp. 974
Author(s):  
David Rodríguez ◽  
Ana I. Tabar ◽  
Miriam Castillo ◽  
Montserrat Martínez-Gomariz ◽  
Isabel C. Dobski ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Gender Differences ◽  
Alternaria Alternata ◽  
Major Allergen ◽  
Recognition Pattern ◽  
Medication Consumption ◽  
Sensitization Pattern

Alternaria alternata is the most important allergenic fungus, with up to 20% of allergic patients affected. The sensitization profile of patients sensitized to A. alternata and how it changes when treated with immunotherapy is not known. Our objective is to determine the allergen recognition pattern of allergic patients to A. alternata and to study its association to the parameters studied in a clinical trial recently published. Sera of 64 patients from the clinical trial of immunotherapy with native major allergen Alt a 1 were analyzed by immunoblotting; 98. 4% of the patients recognized Alt a 1. The percentage of recognition for Alt a 3, Alt a 4, and/or Alt a 6, Alt a 7, Alt a 8, Alt a 10 and/or Alt a 15 was 1.6%, 21.9%, 12.5%, 12.5%, and 12.5% respectively. Of the 64 patients, 45 (70.3%) only recognized Alt a 1 among the allergens present in the A. alternata extract. Immunotherapy with Alt a 1 desensitizes treated patients, reducing their symptoms and medication consumption through the elimination of Alt a 1 sensitization, which is no longer present in the immunoblotting of some patients. There may be gender differences in the pattern of sensitization to A. alternata allergens, among others.

The 31 kd major allergen, ALT a I1563, of Alternaria alternata

1991 ◽  
Vol 88 (6) ◽  
pp. 902-908 ◽  
Author(s):  
Sophie Paris ◽  
Jean Paul Debeaupuis ◽  
Marie Christine Prévost ◽  
Méris Casotto ◽  
Jean-Paul Latgé
Keyword(s):  
Alternaria Alternata ◽  
Major Allergen

scholarly journals Fungi Sensitization in Spain: Importance of the Alternaria alternata Species and Its Major Allergen Alt a 1 in the Allergenicity

2021 ◽  
Vol 7 (8) ◽  
pp. 631
Author(s):  
Verónica P. López Couso ◽  
Miguel Tortajada-Girbés ◽  
David Rodriguez Gil ◽  
Jorge Martínez Quesada ◽  
Ricardo Palacios Pelaez
Keyword(s):  
House Dust ◽  
Alternaria Alternata ◽  
Mediterranean Area ◽  
Major Allergen ◽  
Specific Ige ◽  
House Dust Mites ◽  
Prick Test ◽  
Fungal Allergy ◽  
Continental Area ◽  
Animal Dander

Prevalence of allergy to fungi is around 3–10%. The most prevalent species involved in sensitizations are Alternaria alternata, Aspergillus fumigatus, Cladosporium herbarum, and Penicillium notatum. Our main objective was to estimate the prevalence of fungal sensitization and its variation across Spain. Following the ICH-GCP, we recruited 1156 patients from 15 allergy departments in Spain. Hospitals were selected by bioclimatic areas. Patients underwent a skin prick test (SPT) with fungi, pollens, house dust mites, and animal dander. Specific IgE to Alternaria alternata and Alt a 1 was assessed in patients with positive SPT to fungi. Of the 233 patients (20.2%) sensitized to at least one of the five fungi tested, 162 (69.5%) were sensitized to Alternaria alternata and Alt a 1, of whom 113 (69.8%) were children; 181 (77.7%) were also polysensitized to other allergens. Alternaria alternata and Alt a 1 sensitization was present in 25.4% of patients in the Continental area, 12.0% in the Mediterranean area, 7.0% in the Semidesertic area, and 2.3% in the Oceanic area. Prevalence of sensitization to the other tested sources was 63.8% to pollens, 60.5% to house dust mite, and 38.1% to animal dander. We concluded that the prevalence of fungal allergy is increasing. Fungi are still the fourth source of allergen sensitization. Alternaria alternata sensitization is the most prevalent in allergic patients to fungi. Alt a 1 is present in almost 90% of the patients sensitized to Alternaria alternata.

Gene profiling and expression of major allergen Alt a 1 in Alternaria alternata and related members of the Pleosporaceae family

2019 ◽  
Vol 36 (2) ◽  
pp. 66-71 ◽  
Author(s):  
Fardis Teifoori ◽  
Masoomeh Shams-Ghahfarokhi ◽  
Mehdi Razzaghi-Abyaneh ◽  
Jorge Martinez
Keyword(s):  
Alternaria Alternata ◽  
Major Allergen ◽  
Gene Profiling

IgE binding synthetic peptides of Alt a 1, a major allergen of Alternaria alternata

Peptides ◽  
2003 ◽  
Vol 24 (2) ◽  
pp. 179-185 ◽  
Author(s):  
Viswanath P. Kurup ◽  
Hari M. Vijay ◽  
Veena Kumar ◽  
Laura Castillo ◽  
Nancy Elms
Keyword(s):  
Alternaria Alternata ◽  
Synthetic Peptides ◽  
Major Allergen ◽  
Ige Binding
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