scholarly journals Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor

2009 ◽  
Vol 6 (5-6) ◽  
pp. 230-239 ◽  
Author(s):  
Naohiro Itoh ◽  
Masayasu Okochi ◽  
Shinji Tagami ◽  
Kouhei Nishitomi ◽  
Taisuke Nakayama ◽  
...  
Keyword(s):  
Beta Amyloid ◽  
Amyloid Protein ◽  
Protein Precursor ◽  
Amyloid Protein Precursor ◽  
Beta Amyloid Protein

P3-085: Interaction network of tau protein, beta-amyloid protein, and amyloid protein precursor under oxidative stress in Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_14) ◽  
pp. P651-P652
Author(s):  
Eduardo de SouzaS. Nicolau ◽  
Ana Paula Mendes Silva ◽  
Kenia Kelly Fiaux do Nascimento ◽  
Kelly Silva Pereira ◽  
Gizele Ribeiro dos Santos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tau Protein ◽  
Interaction Network ◽  
Beta Amyloid ◽  
Amyloid Protein ◽  
Protein Precursor ◽  
Amyloid Protein Precursor ◽  
Beta Amyloid Protein

The Drosophila transcript encoded by the beta-amyloid protein precursor-like gene is restricted to the nervous system

Development ◽  
1990 ◽  
Vol 110 (1) ◽  
pp. 185-195
Author(s):  
L.E. Martin-Morris ◽  
K. White
Keyword(s):  
Nervous System ◽  
Neural Development ◽  
Developmental Stages ◽  
Sequence Similarity ◽  
Beta Amyloid ◽  
Amyloid Protein ◽  
Protein Precursor ◽  
Amyloid Protein Precursor ◽  
Beta Amyloid Protein ◽  
App Gene

We have molecularly delineated a Drosophila beta-amyloid protein precursor-like (Appl) gene and analyzed its pattern of expression. Appl defines a new locus within the 1B division of the X-chromosome, a region previously shown to be important for neural development. The genomic limits of the Appl gene were defined by mapping of the Appl cDNAs. The Appl transcript spans approximately 38 kb (1 kb = 10(3) base-pairs) of genomic DNA. Genomic regions surrounding the first two exons were sequenced. The first exon contains 78 nucleotides of the coding sequence and is separated from the second exon by a approximately 21 kb intron. The second exon is 171 nucleotides long and is separated from the third exon by a approximately 7 kb intron. We present in situ RNA localization data that demonstrate that the Appl transcript is found in post-mitotic neurons in all developmental stages, in the central and peripheral nervous systems. Within the nervous system transcripts are not observed in neuroblasts, newly generated neurons and at least one class of presumed glial cells. The temporal and spatial specificity of Appl expression suggests that the gene product has a function that is common to most neurons. Appl cDNA predicts an 886-amino acid polypeptide that exhibits strong sequence similarity to the human beta-amyloid protein precursor (APP) (Rosen et al. 1989). In this paper, we compare the Appl gene expression with the pattern of expression of the beta-amyloid protein precursor (APP) gene in mammals. Furthermore, we suggest that during evolution, a neural-specific function encoded by the APP gene has been selectively maintained.

Alzheimer's disease and control brain contain soluble derivatives of the amyloid protein precursor that end within the .beta. amyloid protein region

Biochemistry ◽  
1992 ◽  
Vol 31 (44) ◽  
pp. 10936-10940 ◽  
Author(s):  
Jennifer M. Pasternack ◽  
Mark R. Palmert ◽  
Marianne Usiak ◽  
Rong Wang ◽  
Heidi Zurcher-Neely ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Beta Amyloid ◽  
Amyloid Protein ◽  
Protein Precursor ◽  
Amyloid Protein Precursor ◽  
Control Brain ◽  
Beta Amyloid Protein ◽  
And Control ◽  
Derivatives Of
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