scholarly journals Diminished Insulin-Mediated Forearm Blood Flow and Muscle Glucose Uptake in Young Men with Low Birth Weight

2010 ◽  
Vol 47 (2) ◽  
pp. 139-147 ◽  
Author(s):  
M.P. Sonne ◽  
L. Højbjerre ◽  
A.C. Alibegovic ◽  
A. Vaag ◽  
B. Stallknecht ◽  
...  
Keyword(s):  
Blood Flow ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Glucose Uptake ◽  
Forearm Blood Flow ◽  
Young Men

scholarly journals Normal Insulin-Stimulated Endothelial Function and Impaired Insulin-Stimulated Muscle Glucose Uptake in Young Adults with Low Birth Weight

2003 ◽  
Vol 88 (3) ◽  
pp. 1252-1257 ◽  
Author(s):  
T. S. Hermann ◽  
C. Rask-Madsen ◽  
N. Ihlemann ◽  
H. Domínguez ◽  
C. B. Jensen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Glucose Uptake ◽  
Insulin Infusion ◽  
Normal Birth Weight ◽  
Weight Group ◽  
Normal Birth ◽  
Birth Weight Group ◽  
Impaired Insulin

Low birth weight has been linked to insulin resistance and cardiovascular disease. We hypothesized that insulin sensitivity of both muscle and vascular tissues were impaired in young men with low birth weight. Blood flow was measured by venous occlusion plethysmography during dose-response studies of acetylcholine and sodium nitroprusside in the forearm of fourteen 21-yr-old men with low birth weight and 16 controls of normal birth weight. Glucose uptake was measured during intraarterial insulin infusion. Dose-response studies were repeated during insulin infusion. The maximal blood flow during acetylcholine infusion was 14.1 ± 2.7 and 14.4 ± 2.1 [ml × (100 ml forearm)−1 × min−1] in low and normal birth weight subjects, respectively. Insulin coinfusion increased acetylcholine-stimulated flow in both groups: 18.0 ± 3.1 vs. 17.9 ± 3.1 [ml × (100 ml forearm)−1 × min−1], NS. Insulin infusion increased glucose uptake significantly in the normal birth weight group, compared with the low birth weight group: 0.40 ± 0.09 to 1.00 ± 0.16 vs. 0.44 ± 0.09 to 0.59 ± 0.1 [μmol glucose × (100 ml forearm)−1 × min−1], P = 0.04. Young men with low birth weight have normal insulin-stimulated endothelial function and impaired insulin-stimulated forearm glucose uptake. Thus, endothelial dysfunction does not necessarily coexist with metabolic alterations in subjects with low birth weight.

Asymmetry of Cerebral Blood Flow Velocity in Low Birth Weight Infants

Neonatology ◽  
2005 ◽  
Vol 87 (3) ◽  
pp. 145-151 ◽  
Author(s):  
Jyothi Swarup ◽  
Robyn Wyman Baker ◽  
Beverly Sobchak Brozanski ◽  
Toby Debra Yanowitz
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Cerebral Blood Flow Velocity ◽  
Low Birth Weight Infants

Effects of an outdoor bicycle-based intervention in healthy rural Indian men with normal and low birth weight

2014 ◽  
Vol 6 (1) ◽  
pp. 27-37 ◽  
Author(s):  
C. Madsen ◽  
P. Mogensen ◽  
N. Thomas ◽  
D. L. Christensen ◽  
I. C. Bygbjerg ◽  
...  
Keyword(s):  
Body Composition ◽  
Insulin Secretion ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Exercise Training ◽  
Exercise Intervention ◽  
Young Men ◽  
Fat Free Mass ◽  
Rural India ◽  
Total Fat

Physical inactivity and low birth weight (LBW) may lead to an increased risk for developing type 2 diabetes. The extent to which LBW individuals may benefit from physical exercise training when compared with those with normal birth weight (NBW) controls is uncertain. We assessed the impact of an outdoor exercise intervention on body composition, insulin secretion and action in young men born with LBW and NBW in rural India. A total of 61 LBW and 56 NBW healthy young men were recruited into the study. The individuals were instructed to perform outdoor bicycle exercise training for 45 min every day. Fasting blood samples, intravenous glucose tolerance tests and bioimpedance body composition assessment were carried out. Physical activity was measured using combined accelerometry and heart rate monitoring during the first and the last week of the intervention. Following the exercise intervention, the LBW group displayed an increase in physical fitness [55.0 ml (O2)/kg min (52.0−58.0)−57.5 ml (O2)/kg min (54.4−60.5)] level and total fat-free mass [10.9% (8.0−13.4)−11.4% (8.0−14.6)], as well as a corresponding decline in the ratio of total fat mass/fat-free mass. In contrast, an increase in total fat percentage as well as total fat mass was observed in the NBW group. After intervention, fasting plasma insulin levels, homoeostasis model assessments (HOMA) of insulin resistance (HOMA-IR) and insulin secretion (HOMA-IS), improved to the same extent in both the groups. In summary, young men born with LBW in rural India benefit metabolically from exercise training to an extent comparable with NBW controls.

Effect of local sympathetic blockade on forearm blood flow and glucose uptake during hypoglycemia

Metabolism ◽  
1999 ◽  
Vol 48 (12) ◽  
pp. 1575-1583 ◽  
Author(s):  
Robert P. Hoffman ◽  
Christine A. Sinkey ◽  
Eva Tsalikian
Keyword(s):  
Blood Flow ◽  
Glucose Uptake ◽  
Forearm Blood Flow ◽  
Sympathetic Blockade
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