Effects of N-Acetylcysteine on Histamine Release by Sodium Fluoride and Compound 48/80 from Isolated Rat Mast Cells

1991 ◽  
Vol 96 (4) ◽  
pp. 338-343 ◽  
Author(s):  
X.J. Hong ◽  
A. Francker ◽  
B. Diamant
Keyword(s):  
Mast Cells ◽  
Histamine Release ◽  
Sodium Fluoride ◽  
Isolated Rat ◽  
Rat Mast Cells

Differential Effects of Sodium Cromoglycate on Adriamycin-Induced Histamine Release from Isolated Rat and Mouse Mast Cells

1988 ◽  
Vol 1 (2) ◽  
pp. 115-118
Author(s):  
Giuliana Decorti ◽  
Fiora Bartoli Klugmann ◽  
L. Candussio ◽  
L. Baldini
Keyword(s):  
Mast Cells ◽  
Histamine Release ◽  
Sodium Cromoglycate ◽  
Inhibitory Activity ◽  
Antineoplastic Drug ◽  
Differential Effects ◽  
Isolated Rat ◽  
Rat Mast Cells

Adriamycin-induced histamine release has been studied on purified mast cells obtained from peritoneal cavities of mice and rats. The activity of the antineoplastic drug was compared with that of the classic basic secretagogue compound 48/80. Rat and mouse mast cells were similarly responsive to adriamycin, on the contrary, the activity of compound 48/80 was more marked in rat than in mouse. The antianaphylactic agent sodium cromoglycate was extremely effective in preventing adriamycin-induced histamine release in both species, whereas, an inhibitory activity against compound 48/80 was evident only in rat mast cells.

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