Time Course of Cellular Infiltration in the Nasal Mucosa during the Immediate Allergic Reaction

1991 ◽  
Vol 95 (2-3) ◽  
pp. 273-277 ◽  
Author(s):  
S. Lozewicz ◽  
E. Gomez ◽  
S. Chalstrey ◽  
D. Gatland ◽  
R.J. Davies
Keyword(s):  
Allergic Reaction ◽  
Nasal Mucosa ◽  
Time Course ◽  
Cellular Infiltration

Time Course of Changes in Absorption of Macromolecule through the Nasal Mucosa after Antigen Challenge in Guinea Pig Model of Allergic Rhinitis

2000 ◽  
Vol 109 (12) ◽  
pp. 1120-1124 ◽  
Author(s):  
Akiyoshi Konno ◽  
Hiroshi Nagata ◽  
Tsutomu Numata ◽  
Nobuhisa Terada ◽  
Hideaki Motosugi ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Guinea Pig ◽  
Nasal Mucosa ◽  
Time Course ◽  
Pig Model ◽  
Antigen Challenge ◽  
Guinea Pig Model

Spontaneous Remission in Experimental Autoimmune Labyrinthitis

1992 ◽  
Vol 101 (12) ◽  
pp. 1007-1014 ◽  
Author(s):  
Shigeharu Yamanobe ◽  
Jeffrey P. Harris
Keyword(s):  
Inner Ear ◽  
Time Course ◽  
Round Window ◽  
Spontaneous Remission ◽  
Intradermal Injection ◽  
Round Window Membrane ◽  
Cellular Infiltration ◽  
Auditory Brain Stem Response ◽  
Hearing Thresholds ◽  
Experimental Autoimmune

We investigated the time course of hearing impairment and cellular infiltration into the inner ear after systemic sensitization of guinea Pigs with a single intradermal injection of bovine inner ear antigen (IEAg) in complete Freund's adjuvant (CFA). Lymphocytes and polymorphonucleocytes appeared mainly in the scala tympani on days 7 to 14, and in addition there was thickening and cellular infiltration of the round window membrane at day 14. These cellular infiltrations resolved after day 28. The auditory brain stem response thresholds from IEAg-sensitized animals were significantly elevated after day 7. Some sensitized animals (n = 5) had spontaneous remissions after day 28; however, the hearing thresholds did not completely recover. These results demonstrate that experimental autoimmune labyrinthitis can be induced by a single inoculation of IEAg-CFA and that remission, as evidenced by clearing of the cochlear cellular infiltration and improved hearing thresholds, can occur spontaneously.

Time course of metabolic activity and cellular infiltration in a murine model of acid-induced lung injury

2012 ◽  
Vol 38 (4) ◽  
pp. 694-701 ◽  
Author(s):  
Vanessa Zambelli ◽  
Giuseppe Di Grigoli ◽  
Margherita Scanziani ◽  
Silvia Valtorta ◽  
Maria Amigoni ◽  
...  
Keyword(s):  
Lung Injury ◽  
Metabolic Activity ◽  
Murine Model ◽  
Time Course ◽  
Cellular Infiltration

scholarly journals Time course of production of SRS-A in the nasal mucosa after antigen challenge.

1989 ◽  
Vol 82 (6) ◽  
pp. 879-886 ◽  
Author(s):  
Akiyoshi Konno ◽  
Nobuhisa Terada ◽  
Eiko Ito
Keyword(s):  
Nasal Mucosa ◽  
Time Course ◽  
Antigen Challenge

Horseradish Peroxidase Permeability across Rat Nasal Mucosa in Selective Stimulation of Substance P Innervation with Capsaicin

1995 ◽  
Vol 104 (11) ◽  
pp. 895-898 ◽  
Author(s):  
Namju Kim ◽  
Soonkwan Hong ◽  
Seayuong Jeon ◽  
Euigee Hwang ◽  
Yang-Gi Min
Keyword(s):  
Electron Microscopy ◽  
Substance P ◽  
Horseradish Peroxidase ◽  
Enzyme Immunoassay ◽  
Nasal Mucosa ◽  
Time Course ◽  
Physiological Role ◽  
Selective Stimulation ◽  
Stimulation Of

To investigate the physiological role of substance P innervation (SPI) in the nasal mucosa from inhaled irritant macromolecules, SPI in the rat nasal mucosa was selectively stimulated with capsaicin and the degree of horseradish peroxidase (HRP) permeability across the nasal epithelium was evaluated by enzyme immunoassay or by histochemical electron microscopy. The serum level of HRP was reduced significantly in capsaicin-administered rats compared to control rats along the time course with quantitative analysis of the enzyme immunoassay. Control rats showed heavy permeation of HRP across the epithelium, but capsaicin-administered rats showed weak permeation of HRP across the epithelium with histochemical electron microscopy. The epithelial lining and its tight junctions were left intact as judged by electron microscopy. In conclusion, selective stimulation of SPI of the rat nasal mucosa with capsaicin decreased the epithelial absorption permeability to HRP without compromising the epithelial integrity. These findings imply that the physiological role of capsaicin-sensitive SPI in the rat mucosa is to protect the airway from inhaled irritant macromolecules.

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