Effects of Cetirizine on Human Eosinophil and Neutrophil Activation in vitro

1991 ◽  
Vol 95 (2-3) ◽  
pp. 158-162 ◽  
Author(s):  
G.M. Walsh ◽  
R. Moqbel ◽  
A. Hartnell ◽  
A.B. Kay
Keyword(s):  
Neutrophil Activation ◽  
Human Eosinophil

scholarly journals Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo

2005 ◽  
Vol 146 (3) ◽  
pp. 344-351 ◽  
Author(s):  
Bruce D Levy ◽  
Lorraine Hickey ◽  
Andrew J Morris ◽  
Mykol Larvie ◽  
Raquel Keledjian ◽  
...  
Keyword(s):  
Phospholipase D ◽  
Human Neutrophil ◽  
Neutrophil Activation ◽  
Peritoneal Inflammation

scholarly journals Suppression of tumor necrosis factor-alpha-induced neutrophil adherence responses by essential oils

2003 ◽  
Vol 12 (6) ◽  
pp. 323-328 ◽  
Author(s):  
Shigeru Abe ◽  
Naho Maruyama ◽  
Kazumi Hayama ◽  
Hiroko Ishibashi ◽  
Shigeharu Inoue ◽  
...  
Keyword(s):  
Essential Oils ◽  
Tumor Necrosis ◽  
Neutrophil Activation ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Neutrophil Adherence ◽  
Factor Alpha ◽  
Anti Inflammatory ◽  
Necrosis Factor

Background:In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited.Aims:To assess their anti-inflammatory activities, effects of essential oils on neutrophil activation were examinedin vitro.Methods:Neutrophil activation was measured by tumor necrosis factor-alpha (TNF-α)-induced adherence reaction of human peripheral neutrophils.Results:All essential oils tested at 0.1% concentration suppressed TNF-α-induced neutrophil adherence, and, in particular, lemongrass, geranium and spearmint oils clearly lowered the reaction even at 0.0125%. Similar inhibitory activities for the neutrophil adherence were obtained by their major constituent terpenoids: citral, geraniol, citronellol and carvone. In contrast, very popular essential oils, tea tree oil and lavender oil, did not display the inhibitory activity at the concentration.Conclusion:Thus, some essential oils used as anti-inflammatory remedies suppress neutrophil activation by TNF-α at a low concentration (0.0125-0.025%)in vitro.

scholarly journals Neutrophil activation in vitro and in vivo in Wegener's granulomatosis

1994 ◽  
Vol 45 (4) ◽  
pp. 1120-1131 ◽  
Author(s):  
Elisabeth Brouwer ◽  
Minke G. Huitema ◽  
A.H. Leontine Mulder ◽  
Peter Heeringa ◽  
Harry van Goor ◽  
...  
Keyword(s):  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Neutrophil Activation

scholarly journals Kruppel-like factor 4 regulates neutrophil activation

2017 ◽  
Vol 1 (11) ◽  
pp. 662-668 ◽  
Author(s):  
Yuyan Shen ◽  
Hong Hong ◽  
Panjamaporn Sangwung ◽  
Stephanie Lapping ◽  
Lalitha Nayak ◽  
...  
Keyword(s):  
Crucial Role ◽  
Neutrophil Function ◽  
Neutrophil Activation ◽  
Key Points

Key Points KLF4 deficiency impairs neutrophil function in vitro and in vivo. This is the first demonstration that KLF4 plays a crucial role in neutrophils.

“Autoregulation” of Human Neutrophil Activation In Vitro: Regulation of Phorbol Myristate Acetate-Induced Neutrophil Activation by Cell Density

1990 ◽  
Vol 47 (5) ◽  
pp. 457-474 ◽  
Author(s):  
Stephen P. Peters ◽  
Franklin Cerasoli ◽  
Kurt H. Albertine ◽  
Marlys H. Gee ◽  
David Berd ◽  
...  
Keyword(s):  
Cell Density ◽  
Phorbol Myristate Acetate ◽  
Human Neutrophil ◽  
Neutrophil Activation ◽  
Myristate Acetate

IN VITRO GLYCOLYSIS RATE OF WHOLE BLOOD AS AN INDICATOR OF NEUTROPHIL ACTIVATION STATE

1993 ◽  
Vol 21 (Supplement) ◽  
pp. S188
Author(s):  
David M Nierman ◽  
Jahangir S Rahman ◽  
Thomas H Kalb ◽  
Clyde B Schechter
Keyword(s):  
Whole Blood ◽  
Neutrophil Activation

Iohexol-Induced Neutrophil Myeloperoxidase Release and Activation upon Contact with Vascular Stent-Graft Material: A Mechanism Contributing to the Postimplantation Syndrome?

2003 ◽  
Vol 10 (5) ◽  
pp. 958-967 ◽  
Author(s):  
Vibeke Videm ◽  
Asbjørn Ødegård ◽  
Hans Olav Myhre
Keyword(s):  
Stent Graft ◽  
Neutrophil Activation ◽  
Human Neutrophils ◽  
Maximal Response ◽  
Graft Material ◽  
Vascular Stent ◽  
Neutrophil Degranulation ◽  
Considerable Individual Variation ◽  
Vitro Effect

Purpose: To investigate whether the contrast medium iohexol alone or in combination with vascular stent-graft material induces neutrophil degranulation. Methods: Human whole blood or isolated human neutrophils were incubated with or without iohexol and vascular stent-graft material. Samples were also drawn from 5 patients undergoing diagnostic angiography using iohexol. Myeloperoxidase and lactoferrin concentrations were determined by enzyme immunoassays. Results: Both in vitro and in the patients, iohexol induced neutrophil degranulation with considerable individual variation in dose sensitivity and timing. The in vitro effect was independent of the type of anticoagulant used (ethylenediamine tetra-acetic acid, heparin, lepirudin). Experiments using isolated neutrophils showed that degranulation was independent of complement activation or platelet-derived mediators. The dose for maximal response varied from 5 to 50 mg I/mL (10.7–107.6 mg/mL iohexol). In vitro, vascular stent-graft material alone did not induce neutrophil degranulation. As compared to iohexol alone, incubation with iohexol and vascular stent-graft material in combination substantially increased the release of myeloperoxidase. Conclusions: Iohexol induces neutrophil degranulation, which is greatly enhanced when combined with vascular stent-graft material. Thus, iohexol-induced neutrophil activation may contribute to an inflammatory response following stent-graft implantation. We speculate that neutrophil activation during other procedures combining catheters and iohexol (e.g., angiography) may induce inflammation, which might have detrimental effects.

Modulation of Normal Human Eosinophil Chemotaxis in vitro by Herbimycin A, Erbstatin and Pervanadate

1998 ◽  
Vol 117 (1) ◽  
pp. 10-13 ◽  
Author(s):  
Amr El-Shazly ◽  
Keisuke Masuyama ◽  
Yasuhiro Samejima ◽  
Masao Eura ◽  
Takeru Ishikawa
Keyword(s):  
Human Eosinophil ◽  
Herbimycin A ◽  
Normal Human ◽  
Eosinophil Chemotaxis
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