Effect of Serotonin on T Lymphocyte Proliferation in vitro in Healthy Individuals

1986 ◽  
Vol 81 (4) ◽  
pp. 378-380 ◽  
Author(s):  
I.A. Khan ◽  
G. Bhardwaj ◽  
N. Malla ◽  
C. Wattal ◽  
S.C. Agarwal
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
Healthy Individuals ◽  
T Lymphocyte Proliferation ◽  
Proliferation In Vitro

scholarly journals LASER MODULATION OF T-LYMPHOCYTE PROLIFERATION IN VITRO

LASER THERAPY ◽  
1998 ◽  
Vol 10 (4) ◽  
pp. 153-158 ◽  
Author(s):  
Atif Agaiby ◽  
Lucy Ghali ◽  
Mary Dyson
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
Laser Modulation ◽  
T Lymphocyte Proliferation ◽  
Proliferation In Vitro

Ganciclovir Suppresses Human T Lymphocyte Proliferation In Vitro.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 5378-5378
Author(s):  
Minoo Battiwalla ◽  
Yiyuan Wu ◽  
Ryotaro Nakamura ◽  
Marija Radovic ◽  
Rajinder P.S. Bajwa ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
Brdu Incorporation ◽  
Human Pbmcs ◽  
Post Transplant ◽  
T Lymphocyte Proliferation ◽  
Proliferation In Vitro ◽  
Cmv Reactivation

Abstract Clinically significant cytomegalovirus (CMV) infection in allogeneic blood or marrow transplant recipients has dramatically declined in recent years by the strategy of early detection of reactivation and pre-emptive therapy with Ganciclovir (GCV). We have previously shown that even in the absence of overt CMV disease, persisting post-transplant antigenemia predicts for increased late relapse and treatment failure. (Nakamura, et al BBMT 2004) In other words, frequent CMV reactivation serves as a surrogate for impaired post-transplant immune reconstitution. To explain the observed association between CMV reactivation and relapse we also raised the possibility that several weeks of GCV therapy could exert a deleterious effect on a fragile immune system. Clinical association between GCV administration and impaired lymphocyte function has not received attention previously; perhaps because of confounding effects from the underlying conditions (HIV or post-transplant) that induce CMV reactivation. We examined the effect of GCV in vitro on normal human PBMCs. Human PBMCs were extracted from normal volunteers and subjected to mitogenic stimulation (PHA) in the absence or presence of varying concentrations of GCV. PHA-induced proliferation, measured by uptake of 3[H]-thymidine after 5 days incubation in RPMI-10% AB serum, was reduced by 35% at peak therapeutic concentrations (10mg/ml) of GCV as opposed to 73% by Tacrolimus (10ng/ml). GCV did not induce lymphocyte apoptosis in the presence or absence of stimulation. Flow cytometry-based BrdU incorporation assays show that GCV exerts a time-dependent impairment of DNA synthesis in lymphocytes. Collectively, these results show that GCV suppresses T-lymphocyte proliferation in vitro at therapeutic concentrations and the likely mechanism of action is inhibition of DNA synthesis. Further work is ongoing to evaluate the effect of GCV on proliferative responses to specific antigens and to confirm these effects in comparison to other drugs used in the transplant setting. Figure Figure

scholarly journals Ganciclovir suppresses human T lymphocyte proliferation in vitro

2006 ◽  
Vol 12 (2) ◽  
pp. 78
Author(s):  
M. Battiwalla ◽  
Y. Wu ◽  
M. Radovic ◽  
R. Nakamura ◽  
R.P.S. Bajwa ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
T Lymphocyte Proliferation ◽  
Human T Lymphocyte ◽  
Proliferation In Vitro

scholarly journals Tryptophan concentration is the main mediator of the capacity of adipose mesenchymal stromal cells to inhibit T-lymphocyte proliferation in vitro

Cytotherapy ◽  
2014 ◽  
Vol 16 (12) ◽  
pp. 1679-1691 ◽  
Author(s):  
Ramón Menta ◽  
Pablo Mancheño-Corvo ◽  
Borja Del Río ◽  
Cristina Ramírez ◽  
Olga DelaRosa ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
T Lymphocyte ◽  
Stromal Cells ◽  
Lymphocyte Proliferation ◽  
T Lymphocyte Proliferation ◽  
Tryptophan Concentration ◽  
Proliferation In Vitro

Dendritic cells as accessory cells in antigen-specific murine T lymphocyte proliferation in vitro

1985 ◽  
Vol 77 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Marcel B.M. Teunissen ◽  
Martien L. Kapsenberg ◽  
Frank E.M. Stiekema ◽  
Hiskias G. Keizer
Keyword(s):  
Dendritic Cells ◽  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
T Lymphocyte Proliferation ◽  
Accessory Cells ◽  
Proliferation In Vitro
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