Differential Effect of Experimental Diabetes on the Early and Late Phase of Contact Sensitivity Reaction in Mice

1986 ◽  
Vol 81 (2) ◽  
pp. 136-140
Author(s):  
W. Ptak ◽  
Maria Rewicka ◽  
A. Gryglewski ◽  
Jolanta Bielecka
Keyword(s):  
Differential Effect ◽  
Experimental Diabetes ◽  
Late Phase ◽  
Contact Sensitivity ◽  
Sensitivity Reaction

Regulation of contact sensitivity reaction: Contrasuppressor T cells and contrasuppressor factor downregulate efferent T suppressor cells

1992 ◽  
Vol 144 (1) ◽  
pp. 95-104 ◽  
Author(s):  
Włodzimierz Ptak ◽  
Krzysztof Bryniarski ◽  
Marian Szczepanik ◽  
Maria Ptak ◽  
Agnieszka Polewska
Keyword(s):  
T Cells ◽  
Suppressor Cells ◽  
Contact Sensitivity ◽  
Sensitivity Reaction ◽  
T Suppressor Cells

scholarly journals A Critical Temporal Window for Selectin-dependent CD4+ Lymphocyte Homing and Initiation of Late-Phase Inflammation in Contact Sensitivity

2004 ◽  
Vol 199 (9) ◽  
pp. 1223-1234 ◽  
Author(s):  
John M. Hwang ◽  
Jun Yamanouchi ◽  
Pere Santamaria ◽  
Paul Kubes
Keyword(s):  
Early Phase ◽  
Molecular Mechanisms ◽  
Late Phase ◽  
Leukocyte Recruitment ◽  
Late Response ◽  
Inflammatory Disorder ◽  
Contact Sensitivity ◽  
Microscopy Technique ◽  
Cd4 Lymphocyte ◽  
Cd4 Lymphocytes

Contact sensitivity (CS) is an inflammatory disorder characterized by early and late phases of leukocyte recruitment. We used a noninvasive intravital microscopy technique allowing for the direct visualization of leukocyte rolling and adhesion on blood vessel endothelium. By blocking specific adhesion molecules, we elucidated the molecular mechanisms mediating early leukocyte recruitment to be E- and P-selectin and demonstrated that leukocyte recruitment in the late phase had a different adhesive profile (mainly α4-integrin). Complete blockade of E- and P-selectin within the first 2 h of leukocyte–endothelial cell interactions (but not later) eliminated selectin-independent leukocyte recruitment at 24 h. Despite the predominance of neutrophils in the early phase, specific elimination of CD4+ lymphocytes in the early phase eliminated the late response. CD4+ lymphocytes homed to skin via E- and P-selectin within the early phase and induced the late phase response. Addition of these same CD4+ lymphocytes 2 h after antigen challenge was too late for these cells to home to the skin and induce late phase responses. Our data clearly demonstrate that the antigen-challenged microenvironment is only accessible to CD4+ lymphocytes for the first 2 h, and that this process is essential for the subsequent recruitment of other leukocyte populations in late phase responses.

Contact Sensitivity in Mice: Differential Effect of Vitamin D3 Derivative (Calcipotriol) and Corticosteroids

1993 ◽  
Vol 67 (2) ◽  
pp. 137-142 ◽  
Author(s):  
J.L. Garrigue ◽  
J.F. Nicolas ◽  
A. Demidem ◽  
H. Bour ◽  
G. Viac ◽  
...  
Keyword(s):  
Vitamin D3 ◽  
Differential Effect ◽  
Contact Sensitivity

IFN gamma-producing CD 8+ T cells (Tc1 cells) mediate the contact sensitivity reaction to DNFB and infiltrate the skin early after hapten challenge

1998 ◽  
Vol 16 ◽  
pp. S165
Author(s):  
Hitoshi Akiba ◽  
Marie-Therese Ducluzeau ◽  
Jeanne Kehren ◽  
Denis Jullien ◽  
Mava Krasteva ◽  
...  
Keyword(s):  
T Cells ◽  
Contact Sensitivity ◽  
Ifn Gamma ◽  
Sensitivity Reaction
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