Inhibition of Antibody-Dependent Cellular Cytotoxicity and Natural Cytotoxicity by Retinoic Acid

1984 ◽  
Vol 75 (1) ◽  
pp. 2-7 ◽  
Author(s):  
O. Eremin ◽  
J. Ashby ◽  
J. Rhodes
Keyword(s):  
Retinoic Acid ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Natural Cytotoxicity

scholarly journals Trispecific killer engager CD16xIL15xCD33 potently induces NK cell activation and cytotoxicity against neoplastic mast cells

2018 ◽  
Vol 2 (13) ◽  
pp. 1580-1584 ◽  
Author(s):  
Hyun Don Yun ◽  
Martin Felices ◽  
Daniel A. Vallera ◽  
Peter Hinderlie ◽  
Sarah Cooley ◽  
...  
Keyword(s):  
Mast Cells ◽  
Nk Cells ◽  
Cell Activation ◽  
Nk Cell ◽  
Systemic Mastocytosis ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Natural Cytotoxicity ◽  
Key Points

Key Points NK cell natural cytotoxicity and antibody-dependent cellular cytotoxicity of patients with systemic mastocytosis are normal. Trispecific killer engagers (161533 TriKE) target NK cells from normal donors and systemic mastocytosis patients to kill mast cells.

scholarly journals PD-1 Expression on NK Cells in Malaria-Exposed Individuals Is Associated with Diminished Natural Cytotoxicity and Enhanced Antibody-Dependent Cellular Cytotoxicity

2020 ◽  
Vol 88 (3) ◽  
Author(s):  
Jacqueline Moebius ◽  
Rajan Guha ◽  
Mary Peterson ◽  
Kaveh Abdi ◽  
Jeff Skinner ◽  
...  
Keyword(s):  
Nk Cells ◽  
Cell Function ◽  
Nk Cell ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Natural Cytotoxicity ◽  
Content Type ◽  
Effector Cells ◽  
Malaria Exposure

ABSTRACT Natural killer (NK) cells are key effector cells of innate resistance capable of destroying tumors and virus-infected cells through cytotoxicity and rapid cytokine production. The control of NK cell responses is complex and only partially understood. PD-1 is an inhibitory receptor that regulates T cell function, but a role for PD-1 in regulating NK cell function is only beginning to emerge. Here, we investigated PD-1 expression on NK cells in children and adults in Mali in a longitudinal analysis before, during, and after infection with Plasmodium falciparum malaria. We found that NK cells transiently upregulate PD-1 expression and interleukin-6 (IL-6) production in some individuals during acute febrile malaria. Furthermore, the percentage of PD-1 expressing NK cells increases with age and cumulative malaria exposure. Consistent with this, NK cells of malaria-naive adults upregulated PD-1 following P. falciparum stimulation in vitro. Additionally, functional in vitro studies revealed that PD-1 expression on NK cells is associated with diminished natural cytotoxicity but enhanced antibody-dependent cellular cytotoxicity (ADCC). These data indicate that PD-1+ NK cells expand in the context of chronic immune activation and suggest that PD-1 may contribute to skewing NK cells toward enhanced ADCC during infections such as malaria.

Natural cytotoxicity and antibody-dependent cellular cytotoxicity (ADCC) is not impaired in patients suffering from chronic hepatitis C

2001 ◽  
Vol 35 (5) ◽  
pp. 650-657 ◽  
Author(s):  
Uta Düesberg ◽  
Angelika M Schneiders ◽  
Dimitri Flieger ◽  
Geneviève Inchauspé ◽  
Tilman Sauerbruch ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Natural Cytotoxicity

scholarly journals Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein–Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2–Infected Individuals

2019 ◽  
Vol 219 (11) ◽  
pp. 1749-1754 ◽  
Author(s):  
Ingrid Karlsson ◽  
Jeanette Linnea Tingstedt ◽  
Gülşen Özkaya Şahin ◽  
Mikkel Hansen ◽  
Zsofia Szojka ◽  
...  
Keyword(s):  
Envelope Glycoprotein ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Hiv 1

scholarly journals Regulation of Antibody-Dependent Cellular Cytotoxicity by IgG Intrinsic and Apparent Affinity for Target Antigen

2007 ◽  
Vol 179 (5) ◽  
pp. 2815-2823 ◽  
Author(s):  
Yong Tang ◽  
Jianlong Lou ◽  
R. Katherine Alpaugh ◽  
Matthew K. Robinson ◽  
James D. Marks ◽  
...  
Keyword(s):  
Target Antigen ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Apparent Affinity
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