A Micromethod for the Detection of TG and TM Cells. Technical Aspects for the Enumeration of Human T-Cell Subpopulations

1982 ◽  
Vol 68 (3) ◽  
pp. 214-218 ◽  
Author(s):  
J.R. Jensen
Keyword(s):  
T Cell ◽  
Technical Aspects ◽  
Human T Cell ◽  
Cell Subpopulations ◽  
T Cell Subpopulations

scholarly journals Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man

1981 ◽  
Vol 153 (2) ◽  
pp. 310-323 ◽  
Author(s):  
JA Ledbetter ◽  
RL Evans ◽  
M Lipinski ◽  
C Cummingham-Rundles ◽  
RA Good ◽  
...  
Keyword(s):  
T Cell ◽  
Biochemical Properties ◽  
T Cell Subsets ◽  
Human T Cell ◽  
Peripheral T Cells ◽  
T Cell Antigens ◽  
Cell Subpopulations ◽  
T Cell Subpopulations ◽  
T Cell Maturation ◽  
Parallel Fashion

We describe the biochemical properties and cell surface distributions of three human T cell antigens (Leu-1, Leu-2a, and Leu-2b) which we postulate to be the homologues of the Lyt-1, Lyt-2, and Lyt-3 antigens that distinguish functional T cell subsets in the mouse. Leu-l, like Lyt-1, is on all thymocytes and peripheral T cells and is present in greater amounts on the helper/inducer subset than on the cytotoxic/suppressor subset. Both antigens increase in parallel fashion during T cell maturation in the thymus and each antigen is carried on a single 67,000-molecular weight (relative) (M(r)) polypeptide chain. Surprisingly, Leu-1 and Lyt-1 each are also expressed in readily detectable amounts on some B celI Ieukemias but not detectably so on normal B cells. Leu-2a and Leu-2b are antigens found only on suppressor/cytotoxic cells in the human and are very similar to the murine Lyt-2 and Lyt-3 antigens. In both species, the two antigens are on the same disulfide- linked multimeric molecules. Disulfide-bond reduction in both species yields subunits of similar size and charge. Lyt-3 and Leu-2b are extremely sensitive to trypsin digestion on viable cells whereas Lyt-2 and Leu-2a are much less so. A different membrane antigen, Leu-3, is an exclusive marker of the helper/inducer subset in man. No mouse homologue for this 55,000-M(r) protein is known. The maintenance of the homologous molecules on functionally distinct T cell subpopulations in two evolutionarily distant species suggests that the Lyt and Leu antigens perform essential functions for the cells on which they are found.

Cytochemistry of Human T-Cell Subpopulations

1980 ◽  
Vol 11 (2) ◽  
pp. 223-233 ◽  
Author(s):  
A. BEVAN ◽  
G. F. BURNS ◽  
L. GRAY ◽  
J. C. CAWLEY
Keyword(s):  
T Cell ◽  
Human T Cell ◽  
Cell Subpopulations ◽  
T Cell Subpopulations

PROLIFERATIVE RESPONSIVENESS OF TWO DISTINCT HUMAN T-CELL SUBPOPULATIONS TO CON A, PHA AND ALLOANTIGENS

1977 ◽  
pp. 512-514 ◽  
Author(s):  
S.R. Webb ◽  
P.M. Lydyard ◽  
L. Moretta ◽  
M. Ferrarini ◽  
M.C. Mingari ◽  
...  
Keyword(s):  
T Cell ◽  
Con A ◽  
Human T Cell ◽  
Cell Subpopulations ◽  
T Cell Subpopulations

In vitro regulation of immunoglobulin synthesis by T-cell subpopulations defined by a new human T-cell antigen (9.3)

1982 ◽  
Vol 72 (1) ◽  
pp. 122-129 ◽  
Author(s):  
Lawrence G. Lum ◽  
Nancy Orcutt-Thordarson ◽  
Margaret C. Seigneuret ◽  
John A. Hansen
Keyword(s):  
T Cell ◽  
Cell Antigen ◽  
Immunoglobulin Synthesis ◽  
Human T Cell ◽  
Cell Subpopulations ◽  
T Cell Subpopulations
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