Suppression of Reaginic Antibodies with Modified Allergens

1981 ◽  
Vol 64 (1) ◽  
pp. 100-114 ◽  
Author(s):  
W.Y. Lee ◽  
A.H. Sehon ◽  
E. Åkerblom
Keyword(s):  
Reaginic Antibodies

Active Bronchial Anaphylaxis in the Rat

1974 ◽  
Vol 52 (6) ◽  
pp. 1114-1118 ◽  
Author(s):  
L. M. Stotland ◽  
N. N. Share
Keyword(s):  
Allergic Asthma ◽  
Specific Antigen ◽  
Female Rats ◽  
Sprague Dawley ◽  
Egg Albumin ◽  
Tracheal Pressure ◽  
Resultant Increase ◽  
Dose Responses ◽  
Reaginic Antibodies ◽  
Anaphylactic Response

Sprague–Dawley female rats were immunized with egg albumin (EA) in aluminum hydroxide gel (AHG) and with or without Bacillus pertussis vaccine (BPV). Fourteen days later, the animals were anesthetized and challenged with EA intravenously. The resultant increase in tracheal pressure was recorded as an index of anaphylactic bronchoconstriction. Ventilation with tracheal pressures of 6 cm H2O (588 N/m2) allowed maximal development of bronchoconstrictor responses to specific antigen challenge that were similar in both pithed and pentobarbital-anesthetized preparations. Forced reinflation of the lungs did not affect the magnitude of the response but did facilitate its recovery. Serum titers evaluated by 3-h and 72-h passive cutaneous anaphylactic reactions indicated that reaginic antibodies were primarily involved, although other immunoglobulins may have played a contributory role. Antigen dose-responses were similar for both the EA-AHG and EA-AHG-BPV immunized groups of animals despite lower reaginic serum titers for the former group. Thus, an immediate-type bronchial anaphylactic response mediated primarily by reaginic antibodies can be elicited in rats and quantitatively assessed. The potential immunologic similarity of these animals to human allergic asthma suggests their utility for further investigation.

IgE and Reaginic Antibodies

1969 ◽  
Vol 62 (9) ◽  
pp. 971-974 ◽  
Author(s):  
D R Stanworth
Keyword(s):  
Reaginic Antibodies

scholarly journals IgE and Reaginic Antibodies

1969 ◽  
Vol 62 (9) ◽  
pp. 975-976 ◽  
Author(s):  
S G O Johansson
Keyword(s):  
Reaginic Antibodies

Reaginic antibodies and helminth infection

1973 ◽  
Vol 93 (18) ◽  
pp. 480-483 ◽  
Author(s):  
E. Jarrett
Keyword(s):  
Helminth Infection ◽  
Reaginic Antibodies

Effect of histamine agonists and antagonists on the production of murine reaginic antibodies

1980 ◽  
Vol 2 (3) ◽  
pp. 236-237 ◽  
Author(s):  
A.P. Baker ◽  
D.A. Holden ◽  
W.J. Smith ◽  
C.P. Sung ◽  
L.W. Chakrin
Keyword(s):  
Reaginic Antibodies
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