Inhibition of Rat Mast Cell Degranulation and Histamine Release by Histamine-Rat Gammaglobulin Conjugate

1979 ◽  
Vol 59 (4) ◽  
pp. 403-407 ◽  
Author(s):  
Takeru Ishikawa ◽  
Tetsuo Shimada ◽  
Nobuko Kessoku ◽  
Masayoshi Kiyoi
Keyword(s):  
Mast Cell ◽  
Histamine Release ◽  
Mast Cell Degranulation

Histamine release and mast cell degranulation induced by 2-4 dinitrophenol in rat tissues

1969 ◽  
Vol 25 (3) ◽  
pp. 244-245 ◽  
Author(s):  
Mercedes P. de Oliveira Antonio ◽  
A. M. Rothschild
Keyword(s):  
Mast Cell ◽  
Histamine Release ◽  
Mast Cell Degranulation ◽  
Rat Tissues

scholarly journals Dimerized Translationally Controlled Tumor Protein-Binding Peptide 2 Attenuates Systemic Anaphylactic Reactions Through Direct Suppression of Mast Cell Degranulation

2021 ◽  
Vol 12 ◽  
Author(s):  
Hyunsoo Cho ◽  
Jiyoung Park ◽  
Hyo Kyeong Kim ◽  
Eun Sook Hwang ◽  
Kyunglim Lee
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Histamine Release ◽  
Cell Function ◽  
Mapk Signaling ◽  
Airway Epithelial Cells ◽  
Calcium Mobilization ◽  
Mast Cell Degranulation ◽  
Binding Peptide ◽  
Translationally Controlled Tumor Protein

Dimerized translationally controlled tumor protein (dTCTP) amplifies allergic responses through activation of several types of immune cells and release of inflammatory mediators. In particular, dTCTP plays an important role in histamine release by triggering mast cells and has been proposed as a target in the treatment of allergic diseases. dTCTP-binding peptide 2 (dTBP2) is known to attenuate severe allergic rhinitis and asthma through inhibition of dTCTP activity on airway epithelial cells and T cells; however, it is unclear whether dTBP2 affects mast cell function and mast cell disease. In this study, we explored the effects of dTBP2 on mast cell degranulation and allergen-induced anaphylactic reactions. We found that bacterial product lipopolysaccharide increased the expression of dTCTP in mast cells and rapidly released dTCTP by the mast cell stimulator compound 48/80. Interestingly, the released dTCTP further promoted mast cell degranulation in an autocrine activation manner and increased calcium mobilization in mast cells, which is essential for degranulation. Furthermore, dTBP2 directly and dose-dependently inhibited in vitro mast cell degranulation enhanced by compound 48/80, suggesting a direct and potent anti-anaphylactic activity of dTBP2. dTBP2 also significantly suppressed the dTCTP-induced degranulation and histamine release through inhibition of the p38 MAPK signaling pathway and suppression of lysosomal expansion and calcium mobilization in mast cells. More importantly, in vivo administration of dTBP2 decreased mortality and significantly attenuated histamine release and inflammatory cytokine production in compound 48/80-induced systemic anaphylactic reactions. These results suggest that dTBP2 is beneficial for the control of anaphylaxis with increased dTCTP.

scholarly journals Mast cell degranulation and histamine release during A/H5N1 influenza infection in influenza-sensitized mice

Life Sciences ◽  
2020 ◽  
Vol 258 ◽  
pp. 118230
Author(s):  
Yulia Desheva ◽  
Andrey Mamontov ◽  
Nadezhda Petkova ◽  
Vadim Karev ◽  
Peter Nazarov
Keyword(s):  
Mast Cell ◽  
Histamine Release ◽  
Influenza Infection ◽  
Mast Cell Degranulation ◽  
H5n1 Influenza
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