scholarly journals Effects of Bone Morphogenic Proteins on Neural Precursor Cells and Regulation during Central Nervous System Injury

Neurosignals ◽  
2009 ◽  
Vol 17 (4) ◽  
pp. 255-264 ◽  
Author(s):  
Jennifer K. Sabo ◽  
Trevor J. Kilpatrick ◽  
Holly S. Cate
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Precursor Cells ◽  
Central Nervous System Injury ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Bone Morphogenic Proteins

scholarly journals NG2 and Olig2 Expression Provides Evidence for Phenotypic Deregulation of Cultured Central Nervous System and Peripheral Nervous System Neural Precursor Cells

Stem Cells ◽  
2007 ◽  
Vol 25 (2) ◽  
pp. 340-353 ◽  
Author(s):  
Cecile Dromard ◽  
Sylvain Bartolami ◽  
Loïc Deleyrolle ◽  
Hirohide Takebayashi ◽  
Chantal Ripoll ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor

Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers of the deadpan and scratch genes is achieved by repression

Development ◽  
1995 ◽  
Vol 121 (11) ◽  
pp. 3549-3560 ◽  
Author(s):  
J.F. Emery ◽  
E. Bier
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Enhancer Element ◽  
Cis Acting ◽  
Neural Genes ◽  
The Central Nervous System

The Drosophila pan-neural genes deadpan (dpn) and scratch (scrt) are expressed in most or all developing neural precursor cells of the central nervous system (CNS) and peripheral nervous system (PNS). We have identified a cis-acting enhancer element driving full pan-neural expression of the dpn gene which is composed of independent CNS- and PNS-specific subelements. We have also identified CNS- and PNS-specific subelements of the scrt enhancer. Deletion analysis of the dpn and scrt PNS-specific subelements reveals that PNS specificity of these two evolutionarily unrelated enhancers is achieved in part by repression of CNS expression. We discuss the implications of the striking organizational similarities of the dpn, scrt, and sna pan-neural enhancers.

scholarly journals Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments

1992 ◽  
Vol 103 (2) ◽  
pp. 589-597 ◽  
Author(s):  
J. Dahlstrand ◽  
L.B. Zimmerman ◽  
R.D. McKay ◽  
U. Lendahl
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Intermediate Filaments ◽  
Intermediate Filament ◽  
Evolutionary Relationship ◽  
Neuronal Cell ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor

Multipotential stem cells in the neural tube give rise to the different neuronal cell types found in the brain. Abrupt changes in intermediate filament gene expression accompany this transition out of the precursor state: transcription of the intermediate filament nestin is replaced by that of the neurofilaments. In order to identify human neural precursor cells, and to learn more about the evolution of the intermediate filaments expressed in the central nervous system, we have isolated the human nestin gene. Despite considerable divergence between the human and rat nestin genes, in particular in the repetitive parts of the carboxy-terminal region, the positions of the introns are perfectly conserved. Two of the three intron positions are also shared by the neurofilaments, but not by other classes of intermediate filaments. This implies that nestin and the neurofilaments had a common ancestor after branching off from the other classes of intermediate filaments, and that nestin separated from the neurofilament branch before the different neurofilament genes diverged. The characterization of human nestin also facilitates the identification of human multipotential neural precursor cells. This will be of importance for central nervous system (CNS) tumor diagnosis and transplant-based clinical approaches to human neurodegenerative diseases.

The mystery of intracellular developmental programmes and timers

2006 ◽  
Vol 34 (5) ◽  
pp. 663-670 ◽  
Author(s):  
M. Raff
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Molecular Mechanisms ◽  
Cell Types ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Animal Development ◽  
Over Time

There has been a revolution in understanding animal development in the last 25 years or so, but there is at least one area of development that has been relatively neglected and therefore remains largely mysterious. This is the intracellular programmes and timers that run in developing precursor cells and change the cells over time. The molecular mechanisms underlying these programmes are largely unknown. My colleagues and I have studied such programmes in two types of rodent neural precursor cells: those that give rise to oligodendrocytes, which make myelin in the CNS (central nervous system), and those that give rise to the various cell types in the retina.

Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system

Development ◽  
1992 ◽  
Vol 116 (4) ◽  
pp. 855-863 ◽  
Author(s):  
C.Q. Doe
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Lineage ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Cell Lineages ◽  
Early Neurogenesis ◽  
Lineage Markers ◽  
Mother Cells ◽  
Thoracic And Abdominal

The first step in generating cellular diversity in the Drosophila central nervous system is the formation of a segmentally reiterated array of neural precursor cells, called neuroblasts. Subsequently, each neuroblast goes through an invariant cell lineage to generate neurons and/or glia. Using molecular lineage markers, I show that (1) each neuroblast forms at a stereotyped time and position; (2) the neuroblast pattern is indistinguishable between thoracic and abdominal segments; (3) the development of individual neuroblasts can be followed throughout early neurogenesis; (4) gene expression in a neuroblast can be reproducibly modulated during its cell lineage; (5) identified ganglion mother cells form at stereotyped times and positions; and (6) the cell lineage of four well-characterized neurons can be traced back to two identified neuroblasts. These results set the stage for investigating neuroblast specification and the mechanisms controlling neuroblast cell lineages.

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