scholarly journals Barbigerone, a Natural Isoflavone, Induces Apoptosis in Murine Lung-Cancer Cells via the Mitochondrial Apoptotic Pathway

2009 ◽  
Vol 24 (1-2) ◽  
pp. 95-104 ◽  
Author(s):  
Zheng-Guang Li ◽  
Ying-Lan Zhao ◽  
Xiaohua Wu ◽  
Hao-Yu Ye ◽  
Aihua Peng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Apoptotic Pathway ◽  
Mitochondrial Apoptotic Pathway ◽  
Murine Lung

scholarly journals BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-21 ◽  
Author(s):  
Meng-Hsuan Cheng ◽  
Hung-Ling Huang ◽  
Yen-You Lin ◽  
Kuan-Hao Tsui ◽  
Pei-Chin Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Oxygen Species ◽  
Apoptotic Pathway ◽  
Induced Apoptosis

Lung cancer is the leading cause of cancer deaths in the world, with a five-year survival rate of less than 30%. Clinically effective chemotherapeutic treatments at the initial stage may eventually face the dilemma of no drug being effective due to drug resistance; therefore, finding new effective drugs for lung cancer treatment is a necessary and important issue. Compounds capable of further increasing the oxidative stress of cancer cells are considered to have anticancer potential because they possessed the ability to induce apoptosis. This study mainly investigated the effects of BA6 (heteronemin), the marine sponge sesterterpene, on lung cancer cell apoptosis, via modulation of mitochondrial reactive oxygen species (mtROS) and oxidative phosphorylation (OXPHOS). BA6 has cellular cytotoxic activities against a variety of cancer cell lines, but it has no effect on nontumor cells. The BA6-treated lung cancer cells show a significant increase in both cellular ROS and mtROS, which in turn caused the loss of mitochondrial membrane potential (MMP). The increase of oxidative stress in lung cancer cells treated with BA6 was accompanied by a decrease in the expression of antioxidant enzymes Cu/Zn SOD, MnSOD, and catalase. In addition, OXPHOS performed in the mitochondria and glycolysis in the cytoplasm were inhibited, which subsequently reduced downstream ATP production. Pretreatment with mitochondria-targeted antioxidant MitoTEMPO reduced BA6-induced apoptosis through the mitochondria-dependent apoptotic pathway, which was accompanied by increased cell viability, decreased mtROS, enhanced MMP, and suppressed expression of cleaved caspase-3 and caspase-9 proteins. In conclusion, the results of this study clarify the mechanism of BA6-induced apoptosis in lung cancer cells via the mitochondrial apoptotic pathway, suggesting that it is a potentially innovative alternative to the treatment of human lung cancer.

scholarly journals De-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (38) ◽  
pp. 62503-62519 ◽  
Author(s):  
Huiying Liu ◽  
Rong Xing ◽  
Xuefang Cheng ◽  
Qingran Li ◽  
Fang Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
De Novo ◽  
Lung Cancer Cells ◽  
Apoptotic Pathway ◽  
Nad Synthesis

Antitumor effects of novel nickel–hydrazone complexes in lung cancer cells

2020 ◽  
Vol 44 (21) ◽  
pp. 9064-9072
Author(s):  
Burak Ay ◽  
Onur Şahin ◽  
Burcu Saygıdeğer Demir ◽  
Yasemin Saygideger ◽  
José M. López-de-Luzuriaga ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Antitumor Effects ◽  
Apoptotic Pathway ◽  
Dose Dependent ◽  
Hydrazone Complexes ◽  
A549 Lung

Two novel nickel(ii) complexes [NiLI]·CH3CN (1·CH3CN) and [Ni(H2LII)(NCS)2]·0.5H2O (2·0.5H2O) were fabricated and in in vitro experiments they both showed the dose dependent cytotoxicity and killed A549 lung cancer cells via an apoptotic pathway.

Investigation of the mechanism and apoptotic pathway induced by 4β cinnamido linked podophyllotoxins against human lung cancer cells A549

APOPTOSIS ◽  
2015 ◽  
Vol 20 (11) ◽  
pp. 1518-1529 ◽  
Author(s):  
Ahmed Kamal ◽  
V. Lakshma Nayak ◽  
Chandrakant Bagul ◽  
M. V. P. S. Vishnuvardhan ◽  
Adla Mallareddy
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Apoptotic Pathway ◽  
Human Lung Cancer Cells

Zoledronic acid induces cell-cycle prolongation in murine lung cancer cells by perturbing cyclin and Ras expression

2011 ◽  
Vol 22 (1) ◽  
pp. 89-98 ◽  
Author(s):  
Ying-Ying Li ◽  
John W-C. Chang ◽  
Ying-Chieh Liu ◽  
Cheng-Hsu Wang ◽  
Hsin-Ju Chang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Zoledronic Acid ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Murine Lung
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