scholarly journals Cardiac Myocytes Derived from Murine Reprogrammed Fibroblasts: Intact Hormonal Regulation, Cardiac Ion Channel Expression and Development of Contractility

2009 ◽  
Vol 24 (1-2) ◽  
pp. 73-86 ◽  
Author(s):  
Kurt Pfannkuche ◽  
Huamin Liang ◽  
Tobias Hannes ◽  
Jiaoya Xi ◽  
Azra Fatima ◽  
...  
Keyword(s):  
Ion Channel ◽  
Cardiac Myocytes ◽  
Hormonal Regulation ◽  
Channel Expression

Dynamic of Ion Channel Expression at the Plasma Membrane of Cardiomyocytes

2012 ◽  
Vol 92 (3) ◽  
pp. 1317-1358 ◽  
Author(s):  
Elise Balse ◽  
David F. Steele ◽  
Hugues Abriel ◽  
Alain Coulombe ◽  
David Fedida ◽  
...  
Keyword(s):  
Ion Channels ◽  
Ion Channel ◽  
Cardiac Myocytes ◽  
Cardiac Myocyte ◽  
Membrane Lipids ◽  
Current Knowledge ◽  
Small Gtpases ◽  
Molecular Organization ◽  
Cardiac Sarcolemma ◽  
Channel Expression

Cardiac myocytes are characterized by distinct structural and functional entities involved in the generation and transmission of the action potential and the excitation-contraction coupling process. Key to their function is the specific organization of ion channels and transporters to and within distinct membrane domains, which supports the anisotropic propagation of the depolarization wave. This review addresses the current knowledge on the molecular actors regulating the distinct trafficking and targeting mechanisms of ion channels in the highly polarized cardiac myocyte. In addition to ubiquitous mechanisms shared by other excitable cells, cardiac myocytes show unique specialization, illustrated by the molecular organization of myocyte-myocyte contacts, e.g., the intercalated disc and the gap junction. Many factors contribute to the specialization of the cardiac sarcolemma and the functional expression of cardiac ion channels, including various anchoring proteins, motors, small GTPases, membrane lipids, and cholesterol. The discovery of genetic defects in some of these actors, leading to complex cardiac disorders, emphasizes the importance of trafficking and targeting of ion channels to cardiac function. A major challenge in the field is to understand how these and other actors work together in intact myocytes to fine-tune ion channel expression and control cardiac excitability.

Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2

2021 ◽  
Vol 1867 (12) ◽  
pp. 166247
Author(s):  
Ling-Ling Qian ◽  
Xiaojing Sun ◽  
Jingchun Yang ◽  
Xiao-Li Wang ◽  
Michael J. Ackerman ◽  
...  
Keyword(s):  
Ion Channel ◽  
Channel Expression ◽  
And Function

scholarly journals Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0172884 ◽  
Author(s):  
Julia Pollak ◽  
Karan G. Rai ◽  
Cory C. Funk ◽  
Sonali Arora ◽  
Eunjee Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ion Channel ◽  
Expression Patterns ◽  
Glioblastoma Stem Cells ◽  
Therapeutic Implications ◽  
Channel Expression

scholarly journals Chronic PKC Activation Inhibits the Repolarizing Cardiac Current by Decreasing the Functional ion Channel Expression at the Plasma Membrane

2011 ◽  
Vol 100 (3) ◽  
pp. 284a
Author(s):  
Kaleef Williams ◽  
Jin O-Uchi ◽  
Angelica Martinez Perez ◽  
Coeli M.B. Lopes
Keyword(s):  
Plasma Membrane ◽  
Ion Channel ◽  
Channel Expression ◽  
Pkc Activation
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