The Effect of Tumor Necrosis Factor Alpha on a Human Renal Cell Carcinoma Xenotransplanted into Nude Mice: Comparison of Intravenous and Intraperitoneal Injection

Oncology ◽  
1995 ◽  
Vol 52 (1) ◽  
pp. 69-75
Author(s):  
G. Hofmockel ◽  
I.D. Bassukas ◽  
D. Heimbach ◽  
R. Metz ◽  
M.P. Wirth
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Renal Cell ◽  
Intraperitoneal Injection ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Human Renal Cell Carcinoma ◽  
Factor Alpha ◽  
Necrosis Factor

In Vivo Antiproliferative Effects of Gamma-Interferon and Tumor Necrosis Factor Alpha in a Rat Renal Cell Carcinoma Model System

1990 ◽  
Vol 143 (6) ◽  
pp. 1247-1251 ◽  
Author(s):  
Reindert J.A. Van moorselaar ◽  
Anton J.M.C. Beniers ◽  
Ben Th. Hendriks ◽  
Peter H. Van Der Meide ◽  
Huub Schellekens ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Model System ◽  
Necrosis Factor Alpha ◽  
Antiproliferative Effects ◽  
Factor Alpha ◽  
Necrosis Factor

Role of hypothalamic interleukin-6 and tumor necrosis factor-alpha in LPS fever in rat

1993 ◽  
Vol 265 (3) ◽  
pp. R512-R517 ◽  
Author(s):  
J. J. Klir ◽  
J. Roth ◽  
Z. Szelenyi ◽  
J. L. McClellan ◽  
M. J. Kluger
Keyword(s):  
Cerebrospinal Fluid ◽  
Tumor Necrosis Factor ◽  
Core Temperature ◽  
Tumor Necrosis Factor Alpha ◽  
Intraperitoneal Injection ◽  
Tumor Necrosis ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

The purpose of this study was to determine, using push-pull perfusion, the levels of interleukin (IL)-1-like, IL-6-like, and tumor necrosis factor-alpha (TNF)-like activity in the anterior hypothalamus during lipopolysaccharide (LPS)-induced fever in rats. Additionally, slow anterior hypothalamic infusions of human recombinant IL-6 (hrIL-6) or TNF (hrTNF) for several hours were performed to determine possible febrile effects of these two cytokines. Artificial cerebrospinal fluid (aCSF) was infused as a control. Samples of cerebrospinal fluid were collected 60 min before and 60, 180, 300, and 420 min after the intraperitoneal injection of LPS. A control group was injected intraperitoneally with saline. The core temperature (measured by biotelemetry) of LPS-injected rats was significantly higher (P < 0.05) than the temperature of the rats injected with saline at 180, 300, and 420 min after the injection. The average postinjection IL-6 levels were significantly higher (P < 0.05) in the LPS-injected group. TNF was significantly higher (P < 0.05) than the baseline only at 180 min. There were no changes in levels of IL-1-like activity. Infusion of hrIL-6 at a level similar to the peak IL-6 level measured during LPS-induced fever resulted in a slowly developing and long-lasting increase in core temperature. Infusion of hrTNF at a level corresponding to the peak TNF level measured during LPS-induced fever did not induce a significant increase in core temperature. These results support the hypothesis that elevated hypothalamic concentrations of IL-6 are involved in the induction of fever elicited by peripheral (intraperitoneal) injection of LPS.

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