Immunohistochemical Detection of p53 Oncoprotein in Human Oral Squamous Cell Carcinomas and Leukoplakias: Comparison with Proliferating Cell Nuclear Antigen Staining and Correlation with Clinicopathological Findings

Oncology ◽  
1993 ◽  
Vol 50 (6) ◽  
pp. 426-429 ◽  
Author(s):  
Hiroto Nishioka ◽  
Yoshio Hiasa ◽  
Isao Hayashi ◽  
Yoshiteru Kitahori ◽  
Noboru Konishi ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Proliferating Cell Nuclear Antigen ◽  
Squamous Cell Carcinomas ◽  
Nuclear Antigen ◽  
Immunohistochemical Detection ◽  
Oral Squamous Cell Carcinomas ◽  
Clinicopathological Findings ◽  
Proliferating Cell

The immunohistochemical expression of p21WAF1/Cip1 and Proliferating cell nuclear antigen in laryngeal squamous cell carcinomas

2006 ◽  
Vol 120 (12) ◽  
pp. 1042-1048 ◽  
Author(s):  
X Li ◽  
S Izumaru ◽  
K Sakamoto ◽  
Y Miyajima ◽  
T Nakashima
Keyword(s):  
Squamous Cell ◽  
Proliferating Cell Nuclear Antigen ◽  
Inverse Correlation ◽  
Squamous Cell Carcinomas ◽  
Nuclear Antigen ◽  
Clinicopathological Parameters ◽  
T Stage ◽  
N Stage ◽  
Tissue Specimens ◽  
Proliferating Cell

The purpose of this study was to assess the significance of the expression of p21WAF1/Cip1 and proliferating cell nuclear antigen (PCNA) in human laryngeal squamous cell carcinomas. Forty-eight patients (25 supraglottic, 23 glottic) who had undergone operations between 1998 and 2003 were included in this study. The Envision immunohistochemistry method was utilized to stain these tissue specimens. The results showed that the immunostaining of p21WAF1/Cip1 do not show any correlation with differentiation, N stage, metastasis, survival, recurrence or the laryngeal site of involvement. A significant inverse correlation was detected between p21WAF1/Cip1 and the T stage. In contrast, the percentage of PCNA labelled cells showed a significant correlation with the T stage, but not with other clinicopathological parameters. There were differences in the expression of p21WAF1/Cip1 and PCNA between the supraglottic and the glottic carcinomas. In conclusion, our findings suggest that p21WAF1/Cip1 and PCNA may play an important role in the progression of carcinoma of the supraglottic larynx.

Sign in / Sign up

Export Citation Format

Share Document