Lonidamine, a New Approach to Cancer Therapy

Oncology ◽  
1984 ◽  
Vol 41 (1) ◽  
pp. 2-6 ◽  
Author(s):  
A. Caputo ◽  
B. Silvestrini
Keyword(s):  
PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28321 ◽  
Author(s):  
Augusto Pessina ◽  
Arianna Bonomi ◽  
Valentina Coccè ◽  
Gloria Invernici ◽  
Stefania Navone ◽  
...  

Toxins ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 582 ◽  
Author(s):  
Bei Cheng ◽  
Peisheng Xu

Although peptide therapeutics have been explored for decades, the successful delivery of potent peptides in vitro and in vivo remains challenging due to the poor stability, low cell permeability, and off-target effects. We developed a redox sensitive polymer-based nanocomplex which can efficiently and stably deliver the peptide drug melittin for cancer therapy. The nanocomplex selectively targets cancer cells through lactobionic acid mediated endocytosis and releases melittin intracellularly upon the trigger of elevated redox potential. In vivo study proved that the targeted nanocomplex shows excellent potency in inhibiting tumor growth in a xenograft colon cancer mouse model. Thus, the polymer/melittin nanocomplexes will provide a new approach for melittin based cancer therapy.


1988 ◽  
Vol 12 (3) ◽  
pp. 243-247 ◽  
Author(s):  
A. A. Pineda ◽  
I. J. Sniecinski ◽  
H. C. Stevenson

Science ◽  
1963 ◽  
Vol 140 (3574) ◽  
pp. 1391-1392 ◽  
Author(s):  
A. Szent-Gyorgyi ◽  
A. Hegyeli ◽  
J. A. McLaughlin
Keyword(s):  

Author(s):  
Ellen S. Vitetta ◽  
Keith A. Krolick ◽  
Muneo Miyama-Inaba ◽  
William Cushley ◽  
Jonathan W. Uhr
Keyword(s):  

2018 ◽  
Vol 66 (8) ◽  
pp. 1083-1087 ◽  
Author(s):  
Shahla Shojaei ◽  
Javad Alizadeh ◽  
James Thliveris ◽  
Navid Koleini ◽  
Elissavet Kardami ◽  
...  

Patients with glioblastoma multiforme (GBM) have an average life expectancy of approximately 15 months. Recently, statins have emerged as a potential adjuvant cancer therapy due to their ability to inhibit cell proliferation and induce apoptosis in many types of cancer. The exact mechanisms that mediate the inhibitory actions of statins in cancer cells are largely unknown. The purpose of this proceeding paper is to discuss some of the known anticancer effects of statins, while focusing on GBM therapy that includes adjunct therapy of statins with chemotherapeutic agents.


Science ◽  
1983 ◽  
Vol 219 (4585) ◽  
pp. 644-650 ◽  
Author(s):  
E. Vitetta ◽  
K. Krolick ◽  
M Miyama-Inaba ◽  
W Cushley ◽  
J. Uhr
Keyword(s):  

2002 ◽  
Vol 3 (12) ◽  
pp. 1739-1751 ◽  
Author(s):  
Gerald Batist ◽  
Jeremy Barton ◽  
Philip Chaikin ◽  
Christine Swenson ◽  
Lauri Welles

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