Total Parenteral Nutrition for Maintenance of Growth, Carcass Mass and Positive Nitrogen Balance in Rats with a Small Transplantable Tumor

Oncology ◽  
1981 ◽  
Vol 38 (5) ◽  
pp. 315-318 ◽  
Author(s):  
Barry Grubbs ◽  
Waid Rogers ◽  
Ivan L. Cameron
1991 ◽  
Vol 81 (2) ◽  
pp. 215-222 ◽  
Author(s):  
M. Salleh M. Ardawi

1. The effect of total parenteral nutrition with or without glutamine enrichment was studied in septic rats after 4 days of treatment. 2. Septic rats treated with glutamine-enriched total parenteral nutrition survived sepsis significantly better than other TPN-treated septic rats: the cumulative percentage of deaths over 4 days in septic rats treated with glutamine-enriched total parenteral nutrition was 25% compared with 55% in septic rats given total parenteral nutrition without glutamine and 70% in septic rats given glucose. 3. Glutamine-enriched total parenteral nutrition resulted in improved nitrogen balance in septic rats: the cumulative nitrogen balance over the 4 days of treatment was the least negative as compared with other groups of septic rats. 4. The rate of loss of intracellular glutamine in skeletal muscle was markedly decreased (P < 0.001) in response to glutamine-enriched total parenteral nutrition in septic rats. 5. The rate of protein synthesis was increased (21.2%) and the rate of protein degradation was decreased (35.5%) in response to glutamine-enriched total parenteral nutrition in septic rats. 6. It is concluded that the administration of glutamine-enriched total parenteral nutrition is beneficial to septic rats and possibly to septic patients.


Author(s):  
A. C. Ames ◽  
A. Thomas

Nitrogen balance was measured in patients receiving balanced parenteral nutrition, most of whom were recovering from major surgery involving the alimentary tract. Their pre-operative nutritional status was found to be an important factor in relation to the nitrogen balance that was induced. Positive nitrogen balance did not occur in patients with little or no pre-operative weight loss, but when the weight loss was more than 6 kg. positive or very small negative nitrogen balances were readily induced. The urine creatine/creatinine ratio which is an indirect index of muscle metabolic activity can be used to anticipate the nitrogen balance that may be achieved in a post-operative patient receiving parenteral nutrition.


1993 ◽  
Vol 17 (2) ◽  
pp. 158-164 ◽  
Author(s):  
Anders Hyltander ◽  
Berndt Arfvidsson ◽  
Ulla Körner ◽  
Rolf Sandström ◽  
Kent Lundholm

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