Corticosteroids Reduce Glial Fibrillary Acidic Protein Expression in Response to Spinal Cord Injury in a Fetal Rat Model of Dysraphism

2009 ◽  
Vol 45 (3) ◽  
pp. 198-204 ◽  
Author(s):  
Antônio Aldo Melo-Filho ◽  
Maria Weber Guimarães Barreto ◽  
Azize Cristina Capelli Nassr ◽  
Fábio Rogério ◽  
Francesco Langone ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glial Fibrillary Acidic Protein ◽  
Protein Expression ◽  
Rat Model ◽  
Acidic Protein ◽  
Fetal Rat ◽  
Cord Injury

Lentiviral-mediated silencing of glial fibrillary acidic protein and vimentin promotes anatomical plasticity and functional recovery after spinal cord injury

2014 ◽  
Vol 93 (1) ◽  
pp. 43-55 ◽  
Author(s):  
Mathieu Desclaux ◽  
Florence E. Perrin ◽  
Anh Do-Thi ◽  
Monica Prieto-Cappellini ◽  
Minerva Gimenez y Ribotta ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glial Fibrillary Acidic Protein ◽  
Functional Recovery ◽  
Acidic Protein ◽  
Anatomical Plasticity ◽  
Cord Injury

scholarly journals Identification of autoantibodies to glial fibrillary acidic protein in spinal cord injury patients

Neuroreport ◽  
2016 ◽  
Vol 27 (2) ◽  
pp. 90-93 ◽  
Author(s):  
Georgene W. Hergenroeder ◽  
Anthony N. Moore ◽  
Karl M. Schmitt ◽  
John B. Redell ◽  
Pramod K. Dash
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glial Fibrillary Acidic Protein ◽  
Acidic Protein ◽  
Cord Injury

scholarly journals Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats

2018 ◽  
Vol 13 (11) ◽  
pp. 1945 ◽  
Author(s):  
VivianeRostirola Elsner ◽  
MayaraFerraz de Menezes ◽  
Fabrício Nicola ◽  
IvyReichert Vital da Silva ◽  
Adriana Vizuete ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glial Fibrillary Acidic Protein ◽  
Acidic Protein ◽  
Histone H4 ◽  
Protein Levels ◽  
Histone H4 Acetylation ◽  
Cord Injury

scholarly journals Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Marco Bonizzato ◽  
Nicholas D. James ◽  
Galyna Pidpruzhnykova ◽  
Natalia Pavlova ◽  
Polina Shkorbatova ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Stress Responses ◽  
Learning Algorithm ◽  
Lumbar Spinal Cord ◽  
Cord Injury ◽  
Potential Synergy ◽  
Lumbar Spinal ◽  
Deep Brain

AbstractA spinal cord injury usually spares some components of the locomotor circuitry. Deep brain stimulation (DBS) of the midbrain locomotor region and epidural electrical stimulation of the lumbar spinal cord (EES) are being used to tap into this spared circuitry to enable locomotion in humans with spinal cord injury. While appealing, the potential synergy between DBS and EES remains unknown. Here, we report the synergistic facilitation of locomotion when DBS is combined with EES in a rat model of severe contusion spinal cord injury leading to leg paralysis. However, this synergy requires high amplitudes of DBS, which triggers forced locomotion associated with stress responses. To suppress these undesired responses, we link DBS to the intention to walk, decoded from cortical activity using a robust, rapidly calibrated unsupervised learning algorithm. This contingency amplifies the supraspinal descending command while empowering the rats into volitional walking. However, the resulting improvements may not outweigh the complex technological framework necessary to establish viable therapeutic conditions.

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