scholarly journals Effects of Neonatal Stress and Morphine on Kappa Opioid Receptor Signaling

Neonatology ◽  
2009 ◽  
Vol 96 (4) ◽  
pp. 235-243 ◽  
Author(s):  
Thuy N. Vien ◽  
Christine A. Gleason ◽  
Sarah L. Hays ◽  
Ronald J. McPherson ◽  
Charles Chavkin ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Receptor Signaling ◽  
Kappa Opioid ◽  
Neonatal Stress

Sex differences in the modulation of mouse nest building behavior by kappa opioid receptor signaling

2020 ◽  
Vol 177 ◽  
pp. 108254 ◽  
Author(s):  
Moriah L. Jacobson ◽  
Hildegard A. Wulf ◽  
Mumeko C. Tsuda ◽  
Caroline A. Browne ◽  
Irwin Lucki
Keyword(s):  
Sex Differences ◽  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Nest Building ◽  
Receptor Signaling ◽  
Kappa Opioid ◽  
Building Behavior

scholarly journals Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula

2020 ◽  
Vol 13 ◽  
pp. 100267 ◽  
Author(s):  
Sarah C. Simmons ◽  
Ryan D. Shepard ◽  
Shawn Gouty ◽  
Ludovic D. Langlois ◽  
William J. Flerlage ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Kappa Opioid Receptor ◽  
Receptor Signaling ◽  
Kappa Opioid ◽  
Lateral Habenula

scholarly journals Dynorphin-Kappa Opioid Receptor Signaling Partly Mediates Estrogen Negative Feedback Effect on LH Pulses in Female Rats

2013 ◽  
Vol 59 (3) ◽  
pp. 266-272 ◽  
Author(s):  
Mst. Parvin MOSTARI ◽  
Nahoko IEDA ◽  
Chikaya DEURA ◽  
Shiori MINABE ◽  
Shunji YAMADA ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Negative Feedback ◽  
Kappa Opioid Receptor ◽  
Feedback Effect ◽  
Female Rats ◽  
Receptor Signaling ◽  
Kappa Opioid

scholarly journals Alcohol Drinking Alters Stress Response to Predator Odor via Extended Amygdala Kappa Opioid Receptor Signaling in Male Mice

2019 ◽  
Author(s):  
Lara S. Hwa ◽  
Sofia Neira ◽  
Meghan E. Flanigan ◽  
Christina M. Stanhope ◽  
Melanie M. Pina ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Stress Responses ◽  
Alcohol Drinking ◽  
Kappa Opioid Receptor ◽  
Predator Odor ◽  
Stria Terminalis ◽  
Receptor Signaling ◽  
Kappa Opioid ◽  
Bed Nucleus ◽  
Heavy Alcohol

AbstractMaladaptive responses to stress are a hallmark of alcohol use disorder, but the mechanisms that underlie this are not well characterized. Here we show that kappa opioid receptor signaling in the bed nucleus of the stria terminalis (BNST) is a critical molecular substrate underlying abnormal stress responses to predator odor following heavy alcohol drinking. Exposure to predator odor during protracted withdrawal from intermittent alcohol drinking resulted in enhanced prefrontal cortex (PFC)-driven excitation of prodynorphin-containing neurons in the BNST compared to drinking or stress alone. Furthermore, deletion of prodynorphin in the BNST and chemogenetic inhibition of the PFC-BNST pathway restored abnormal responses to predator odor in alcohol-exposed mice. These findings suggest that increased corticolimbic drive may promote abnormal stress behavioral responses to predator odor during protracted withdrawal from heavy drinking. Various nodes of this PFC-BNST dynorphin-related circuit may serve as potential targets for potential therapeutic mediation as well as biomarkers of negative responses to stress following heavy alcohol drinking.Impact StatementHeavy alcohol drinking primes dynorphin / kappa opioid systems in the bed nucleus of the stria terminalis to alter stress responses in mice.

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