Acquired Resistance to All-Trans Retinoic Acid Therapy in Acute Promyelocytic Leukemia

1996 ◽  
Vol 19 (1) ◽  
pp. 10-13
Author(s):  
Monique Cornic ◽  
Laurent Delva ◽  
Sylvie Castaigné ◽  
Philippe Lefebvre ◽  
Nicole Balitrand ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Acute Promyelocytic Leukemia ◽  
Acquired Resistance ◽  
Promyelocytic Leukemia ◽  
Acid Therapy ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals Molecular evaluation of response to all-trans-retinoic acid therapy in patients with acute promyelocytic leukemia

Blood ◽  
1991 ◽  
Vol 77 (8) ◽  
pp. 1657-1659 ◽  
Author(s):  
F Lo Coco ◽  
G Avvisati ◽  
D Diverio ◽  
MC Petti ◽  
M Alcalay ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Acute Promyelocytic Leukemia ◽  
High Frequency ◽  
Southern Blot Analysis ◽  
Molecular Level ◽  
Promyelocytic Leukemia ◽  
Acid Therapy ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Leukemic Clone

Abstract The advent of retinoic acid (RA) in the treatment of acute promyelocytic leukemia (APL) has led to a high frequency of short- lasting complete remissions (CR). We studied the response to RA by molecularly analyzing the RA receptor alpha (RAR alpha) locus, which has recently been shown to be rearranged in all APLs. Southern blot analysis demonstrated that the RAR alpha rearrangements persisted in the APL samples containing maturing myeloid cells 2 to 3 weeks after the start of RA treatment, but disappeared after 5 to 8 weeks, when the patients achieved CR. Our investigations provide clear evidence that CR occurs at molecular level and that there is reconstitution of an apparently normal, nonclonal hematopoiesis. Further, it shows that RA acts by triggering differentiation rather than by exerting a cytotoxic effect on the leukemic clone.

Gangrenous cheilitis associated with all-trans retinoic acid therapy for acute promyelocytic leukemia

2009 ◽  
Vol 91 (1) ◽  
pp. 132-135 ◽  
Author(s):  
Mariko Tanaka ◽  
Noriyasu Fukushima ◽  
Hidekazu Itamura ◽  
Chisako Urata ◽  
Masako Yokoo ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Acid Therapy ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals 4-Oxo Retinoic Acid for Refractory Acute Promyelocytic Leukemia in Children with All-Trans Retinoic Acid Therapy.

1995 ◽  
Vol 41 (4) ◽  
pp. 493-498 ◽  
Author(s):  
Kimitaka TAKITANI ◽  
Hiroshi TAMAI ◽  
Takao MORINOBU ◽  
Naohisa KAWAMURA ◽  
Munenori MIYAKE ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Acid Therapy ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Leukemia In Children

Ileal ulceration during all-trans-retinoic acid therapy for acute promyelocytic leukemia

2011 ◽  
Vol 35 (6) ◽  
pp. e89-e90
Author(s):  
Sanjeev K. Sharma ◽  
Pravas Mishra ◽  
Tulika Seth ◽  
Manoranjan Mahapatra
Keyword(s):  
Retinoic Acid ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Acid Therapy ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid
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