The Prognostic Role of Alterations of the p53 Tumor Suppressor Gene in Superficial and Advanced Stage Bladder Cancer

1995 ◽  
Vol 18 (3) ◽  
pp. 202-210
Author(s):  
M.A. Kuczyk ◽  
C. Bokemeyer ◽  
H.-J. Schmoll ◽  
U. Jonas
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Advanced Stage ◽  
Prognostic Role ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene

DETECTION OF LOSS OF HETEROZYGOSITY IN THE P53 TUMOR-SUPPRESSOR GENE WITH PCR IN THE URINE OF PATIENTS WITH BLADDER CANCER

2000 ◽  
pp. 1039 ◽  
Author(s):  
MARTIN G. FRIEDRICH &NA; ◽  
ANDREAS ERBERSDOBLER ◽  
HARTWIG SCHWAIBOLD ◽  
STEFAN CONRAD ◽  
EDITH HULAND ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Loss Of Heterozygosity ◽  
Suppressor Gene ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene

scholarly journals A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development

Oncogene ◽  
2000 ◽  
Vol 19 (8) ◽  
pp. 1052-1058 ◽  
Author(s):  
D J Jerry ◽  
F S Kittrell ◽  
C Kuperwasser ◽  
R Laucirica ◽  
E S Dickinson ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Tumor Development ◽  
Suppressor Gene ◽  
Specific Model ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene

DETECTION OF LOSS OF HETEROZYGOSITY IN THE P53 TUMOR-SUPPRESSOR GENE WITH PCR IN THE URINE OF PATIENTS WITH BLADDER CANCER

2000 ◽  
Vol 163 (3) ◽  
pp. 1039-1042 ◽  
Author(s):  
MARTIN G. FRIEDRICH ◽  
ANDREAS ERBERSDOBLER ◽  
HARTWIG SCHWAIBOLD ◽  
STEFAN CONRAD ◽  
EDITH HULAND ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Loss Of Heterozygosity ◽  
Suppressor Gene ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene

Expression of p53 Protein in Pterygium

1998 ◽  
Vol 8 (3) ◽  
pp. 157-161 ◽  
Author(s):  
C. Onur ◽  
D. Orhan ◽  
M. Orhan ◽  
S. Dizbay Sak ◽  
Ö. Tulunay ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Uv Radiation ◽  
P53 Protein ◽  
Suppressor Gene ◽  
Tumor Formation ◽  
Nuclear Staining ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene

Purpose The pathogenesis of pterygium is still not completely understood and many environmental factors, including ultraviolet (UV) radiation, play an important role in its etiology. Chronic exposure to UV radiation causes mutations in the p53 tumor suppressor gene, eventually leading to tumor formation. We analyzed the immunohistochemical expression of p53 proteins in pterygial tissues to determine the role of the p53 tumor suppressor gene in the development of pterygium. Methods Pterygial specimens were studied immunohistochemically using antibodies against p53 protein. Results Out of 38 specimens studied, 35 (92.1%) had conjunctival epithelial cells without p53 specific nuclear staining. Only three specimens (7.9%) had a few p53 stained cells. The role of UV radiation in the pathogenesis of pterygium is supported by epidemiological, geographical and microscopic findings. However, our results are not consistent with these data on a genetic basis. Conclusions We conclude that defective p53 tumor suppressor gene function seems to have no role in the pathogenesis of pterygium.

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