Influence of Tumoral Microvessel Density on the Recurrence-Free Survival in Human Breast Cancer: Preliminary Results

1994 ◽  
Vol 17 (1) ◽  
pp. 44-49 ◽  
Author(s):  
A. Obermair ◽  
K. Czerwenka ◽  
C. Kurz ◽  
P. Buxbaum ◽  
M. Schemper ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Microvessel Density ◽  
Human Breast Cancer ◽  
Recurrence Free Survival ◽  
Human Breast ◽  
Free Survival ◽  
Preliminary Results

scholarly journals Screening of a Novel Upregulated lncRNA, A2M-AS1, That Promotes Invasion and Migration and Signifies Poor Prognosis in Breast Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Kai Fang ◽  
Hu Caixia ◽  
Zhang Xiufen ◽  
Guo Zijian ◽  
Lihua Li
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Expression Profiles ◽  
Differentially Expressed ◽  
Human Breast ◽  
Free Survival ◽  
Invasion And Migration ◽  
Basal Like Breast Cancer ◽  
And Migration ◽  
Cancer Tissues

Understanding of prognostic factors and therapeutic targets for breast cancer is imperative for guidance of patient care. We studied 1203 tumour samples from the Gene Expression Omnibus (GEO) to evaluate potential genes related to breast cancer. R software was used to analyse differentially expressed long noncoding RNAs (lncRNAs) in the RNA microarray expression profiles GSE45827 and GSE65216 and to identify a series of differentially expressed lncRNAs associated with human breast cancer. Of these lncRNAs, A2M-AS1, a lncRNA that has not been previously reported, was significantly upregulated in human breast cancer tissues compared with adjacent nontumour tissues. Importantly, A2M-AS1 upregulation was significantly associated with ER-negative, HER2-positive, and basal-like breast cancer and with poor recurrence-free survival and metastasis-free survival in breast cancer patients. After validating these results in 96 collected human breast cancer tissues and 64 paired adjacent noncancerous tissues, we further investigated the roles of A2M-AS1 in human ER-negative and basal-like breast cancer cells. The results revealed that A2M-AS1 significantly promotes human breast cancer cell proliferation, invasion, and migration. Additionally, bioinformatics analysis of genes coexpressed with A2M-AS1 in the context of human breast cancer combined with qRT-PCR and Western blot assays revealed that A2M-AS1 exerts regulatory effects on downstream factors in the cell adhesion molecule pathway, including CD2 and SELL. These results imply that A2M-AS1 might be a promising candidate prognostic factor and therapeutic target for breast cancer.

scholarly journals Neuroligin 4X overexpression in human breast cancer is associated with poor relapse-free survival

PLoS ONE ◽  
2017 ◽  
Vol 12 (12) ◽  
pp. e0189662 ◽  
Author(s):  
Henry J. Henderson ◽  
Balasubramanyam Karanam ◽  
Rajeev Samant ◽  
Komal Vig ◽  
Shree R. Singh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Relapse Free Survival ◽  
Free Survival

Microvessel density and vessel invasion in lymph-node-negative breast cancer: Effect on recurrence-free survival

1995 ◽  
Vol 62 (2) ◽  
pp. 126-131 ◽  
Author(s):  
Andreas Obermair ◽  
Christine Kurz ◽  
Klaus Czerwenka ◽  
Martin Thoma ◽  
Alexandra Kaider ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Microvessel Density ◽  
Recurrence Free Survival ◽  
Free Survival ◽  
Node Negative ◽  
Vessel Invasion ◽  
Node Negative Breast Cancer

scholarly journals RIPPLY2 is differentially expressed in brain metastatic human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Human Breast Cancer ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Human Breast ◽  
Primary Tumors ◽  
Free Survival ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that ripply transcriptional repressor 2, encoded by RIPPLY2, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. RIPPLY2 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of RIPPLY2 in primary tumors was significantly correlated with patient recurrence-free survival. Modulation of RIPPLY2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

Hormonal approaches to the chemoprevention of endocrine-dependent tumors.

1999 ◽  
pp. 483-485 ◽  
Author(s):  
A Manni
Keyword(s):  
Breast Cancer ◽  
Aromatase Inhibitors ◽  
Human Breast Cancer ◽  
Premenopausal Women ◽  
Human Breast ◽  
Preliminary Results ◽  
Lhrh Agonists ◽  
Small Doses ◽  
Alternative Approaches ◽  
Common Malignancy

The estrogen dependency of human breast cancer has been successfully exploited in the treatment of early and advanced diseases and provides a unique opportunity for chemoprevention of this common malignancy. Preliminary results with the antiestrogens Tamoxifen and Raloxifene show an encouraging reduction in the incidence of breast cancer. Alternative approaches include the use of highly selective and non-toxic aromatase inhibitors and, in premenopausal women, the use of LHRH agonists in conjunction with the administration of small doses of estrogen and progesterone. The rationale for these chemopreventive strategies and their possible limitations are briefly discussed.

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