scholarly journals HCO3--Dependent Impact of Na+,K+,2Cl- Cotransport in Vascular Smooth Muscle Excitation-Contraction Coupling

2009 ◽  
Vol 23 (4-6) ◽  
pp. 407-414 ◽  
Author(s):  
Svetlana V. Koltsova ◽  
Oksana G. Luneva ◽  
Julie L. Lavoie ◽  
Johanne Tremblay ◽  
Georgy V. Maksimov ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling

Airway smooth muscle excitation-contraction coupling and airway hyperresponsiveness

2005 ◽  
Vol 83 (8-9) ◽  
pp. 725-732 ◽  
Author(s):  
Simon Hirota ◽  
Peter B Helli ◽  
Adriana Catalli ◽  
Allyson Chew ◽  
Luke J Janssen
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Signaling Pathways ◽  
Airway Smooth Muscle ◽  
Airway Hyperresponsiveness ◽  
Rho Kinase ◽  
Shortness Of Breath ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Hallmark Feature

The primary complaints from patients with asthma pertain to function of airway smooth muscle (ASM) function including shortness of breath, wheezing, and coughing. Thus, it is imperative to better understand the mechanisms underlying excitation-contraction coupling in ASM. Here, we review the various signaling pathways underlying contraction in ASM, and then examine how these are altered in asthma and airway hyperresponsiveness (a hallmark feature of asthma). Throughout, we highlight how studies of vascular smooth muscle have helped or hindered progress in understanding ASM physiology and pathophysiology.Key words: airway smooth muscle, vascular smooth muscle, excitation-contraction coupling, calcium, Rho-kinase.

Calcium and excitation–contraction coupling in vascular smooth muscles

1982 ◽  
Vol 60 (4) ◽  
pp. 483-488 ◽  
Author(s):  
George B. Weiss
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Relative Size ◽  
Smooth Muscles ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
High K ◽  
Renal Vessels ◽  
Quantitative Separation ◽  
High Concentrations

The roles of Ca2+ in excitation–contraction coupling in vascular smooth muscle have been difficult to delineate, primarily because unambiguous association of specific Ca2+ components with morphologically defined cellular structures could not be attained. More recent use of washouts in La3+-substituted solutions at low temperature (to remove superficial Ca2+ and retain cellular Ca2+), Scatchard-coordinate plots (to identify incubation conditions appropriate for examining predominantly high or low affinity Ca2+ components), and high concentrations of Sr2+ (to remove high but not low affinity Ca2+) have facilitated qualitative and quantitative separation of different Ca2+ fractions. The release of high affinity Ca2+ elicited with norepinephrine and the increase in uptake of low affinity Ca2+ obtained with high K+ have been clearly demonstrated, and may directly measure or indirectly reflect changes in the level of intracellular free Ca2+. In other types of vascular smooth muscle (e.g., renal vessels, coronary arteries), similar Ca2+ components also appear to be present, but their relative size and functional importance for regulation of contractile responsiveness can differ.

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