scholarly journals Role of G Protein-Coupled Receptor Kinase-2 in Peroxisome Proliferator-Activated Receptor Gamma-Mediated Modulation of Blood Pressure and Renal Vascular Reactivity in SHR

2009 ◽  
Vol 30 (3) ◽  
pp. 201-208 ◽  
Author(s):  
Zivar Yousefipour ◽  
Adebayo Oyekan ◽  
Mohammad Newaz
Keyword(s):  
Blood Pressure ◽  
G Protein ◽  
Vascular Reactivity ◽  
Peroxisome Proliferator ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Peroxisome Proliferator Activated Receptor ◽  
Renal Vascular ◽  
G Protein Coupled

scholarly journals Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia

2015 ◽  
Vol 7 (290) ◽  
pp. 290ra88-290ra88 ◽  
Author(s):  
Vasyl Holobotovskyy ◽  
Yee Seng Chong ◽  
Jennifer Burchell ◽  
Bo He ◽  
Michael Phillips ◽  
...  
Keyword(s):  
Blood Pressure ◽  
G Protein ◽  
Vascular Function ◽  
Gestational Hypertension ◽  
Peroxisome Proliferator ◽  
Protein Signaling ◽  
Current Standard ◽  
Guanine Nucleotide Binding Protein ◽  
Peroxisome Proliferator Activated Receptor

Preeclampsia is a systemic vascular disorder of pregnancy and is associated with increased sensitivity to angiotensin II (AngII) and hypertension. The cause of preeclampsia remains unknown. We identified the role of regulator of G protein (heterotrimeric guanine nucleotide–binding protein) signaling 5 (RGS5) in blood pressure regulation during pregnancy and preeclampsia. RGS5 expression in human myometrial vessels is markedly suppressed in gestational hypertension and/or preeclampsia. In pregnant RGS5-deficient mice, reduced vascular RGS5 expression causes gestational hypertension by enhancing vascular sensitivity to AngII. Further challenge by increasing AngII results in preeclampsia-like symptoms, namely, more severe hypertension, proteinuria, placental pathology, and reduced birth weight. In pregnant heterozygote null mice, treatment with peroxisome proliferator–activated receptor (PPAR) agonists normalizes vascular function and blood pressure through effects on RGS5. These findings highlight a key role of RGS5 at the interface between AngII and PPAR signaling. Because preeclampsia is refractory to current standard therapies, our study opens an unrecognized and urgently needed opportunity for treatment of gestational hypertension and preeclampsia.

Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states

2017 ◽  
Vol 131 (3) ◽  
pp. 247-260 ◽  
Author(s):  
Dan Zhang ◽  
Wing Yan So ◽  
Yi Wang ◽  
Shang Ying Wu ◽  
Qianni Cheng ◽  
...  
Keyword(s):  
G Protein ◽  
Peroxisome Proliferator ◽  
G Protein Coupled Receptor ◽  
Β Cells ◽  
Peroxisome Proliferator Activated Receptor ◽  
G Protein Coupled

Resident G-protein-coupled receptor 120 (GPR120) activation exhibits insulinotropic effects in rodent islets and β-cells. GPR120 expression in β-cells and insulinotropic effects of GPR120 activation are changed in differential ways in obese non-diabetic (OND) and diabetic states. Peroxisome proliferator-activated receptor γ (PPARγ) may facilitate these alterations.

scholarly journals Peroxisome Proliferator-activated Receptor γ Regulates Expression of the Anti-lipolytic G-protein-coupled Receptor 81 (GPR81/Gpr81)

2009 ◽  
Vol 284 (39) ◽  
pp. 26385-26393 ◽  
Author(s):  
Ellen H. Jeninga ◽  
Anne Bugge ◽  
Ronni Nielsen ◽  
Sander Kersten ◽  
Nicole Hamers ◽  
...  
Keyword(s):  
G Protein ◽  
Peroxisome Proliferator ◽  
G Protein Coupled Receptor ◽  
Peroxisome Proliferator Activated Receptor ◽  
G Protein Coupled

scholarly journals Role of G protein-coupled receptor kinase 2 in tumoral angiogenesis

2014 ◽  
Vol 1 (4) ◽  
pp. e969166 ◽  
Author(s):  
Verónica Rivas ◽  
Laura Nogués ◽  
Clara Reglero ◽  
Federico Mayor ◽  
Petronila Penela
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2; The role of NADPH oxidase 4

2016 ◽  
Vol 28 (3) ◽  
pp. 190-203 ◽  
Author(s):  
Tiju Theccanat ◽  
Jennifer L. Philip ◽  
Abdur M. Razzaque ◽  
Nicholas Ludmer ◽  
Jinju Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nadph Oxidase ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Nadph Oxidase 4 ◽  
G Protein Coupled

scholarly journals Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema

Hypertension ◽  
2020 ◽  
Vol 76 (5) ◽  
pp. 1625-1636 ◽  
Author(s):  
Jessica Gambardella ◽  
Daniela Sorriento ◽  
Maria Bova ◽  
Mariarosaria Rusciano ◽  
Stefania Loffredo ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
G Protein ◽  
Molecular Mechanisms ◽  
No Production ◽  
Receptor Kinase ◽  
Severe Phenotype ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

Excessive BK (bradykinin) stimulation is responsible for the exaggerated permeabilization of the endothelium in angioedema. However, the molecular mechanisms underlying these responses have not been investigated. BK receptors are Gq-protein-coupled receptors phosphorylated by GRK2 (G protein-coupled receptor kinase 2) with a hitherto unknown biological and pathophysiological significance. In the present study, we sought to identify the functional role of GRK2 in angioedema through the regulation of BK signaling. We found that the accumulation of cytosolic Ca 2+ in endothelial cells induced by BK was sensitive to GRK2 activity, as it was significantly augmented by inhibiting the kinase. Accordingly, permeabilization and NO production induced by BK were enhanced, as well. In vivo, mice with reduced GRK2 levels in the endothelium (Tie2-CRE/GRK2 fl+/fl − ) exhibited an increased response to BK in terms of vascular permeability and extravasation. Finally, patients with reduced GRK2 levels displayed a severe phenotype of angioedema. Taken together, these findings establish GRK2 as a novel pivotal regulator of BK signaling with an essential role in the pathophysiology of vascular permeability and angioedema.

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