Tumor Specificity of Monoclonal Antibodies to Carcinoembryonic Antigen

Tumor Biology ◽  
1990 ◽  
Vol 11 (1-2) ◽  
pp. 5-19 ◽  
Author(s):  
Fairouz Zoubir ◽  
Jan Zeromski ◽  
Jan Sikora ◽  
Jan Szmeja ◽  
Anders Hedin ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Carcinoembryonic Antigen ◽  
Tumor Specificity

Conformational epitopes specific to carcinoembryonic antigen defined by monoclonal antibodies raised against colon cancer xenografts

1989 ◽  
Vol 42 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Yoichi Sakurai ◽  
Setsuo Hirohashi ◽  
Takashi Ohishi ◽  
Yukio Shimosato ◽  
Susumu Kodaira ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Monoclonal Antibodies ◽  
Carcinoembryonic Antigen ◽  
Conformational Epitopes

Standardization, specificity, and diagnostic sensitivity of four immunoassays for carcinoembryonic antigen

1991 ◽  
Vol 37 (2) ◽  
pp. 231-236 ◽  
Author(s):  
Ole P Börmer
Keyword(s):  
Colorectal Cancer ◽  
Monoclonal Antibodies ◽  
Carcinoembryonic Antigen ◽  
Normal Values ◽  
The Other ◽  
Reference Limit ◽  
Sandwich Type ◽  
Reference Preparation ◽  
Colorectal Cancer Patients

Abstract Four "sandwich"-type immunoassays for carcinoembryonic antigen (CEA) based on monoclonal antibodies (Abbott CEA-RIA Monoclonal, Pharmacia/Wallac Delfia CEA kit, Roche CEA EIA Duomab 60, and our in-house immunoradiometric assay) were compared for 357 samples from colorectal cancer patients and samples from 48 patients with chronic liver disease or with acute, irrelevant diseases. Relative to a common 5 micrograms/L reference limit, all four assays agreed regarding classification in 92% to 94% of the samples in the colorectal cancer samples, with the Abbott and Roche assays giving slightly more "normal" values. Cross-testing of CEA standards and the 1st International Reference Preparation 73/601 showed that calibration differences could not be eliminated by the use of a common standard. It has been earlier demonstrated that the monoclonal antibodies in the Roche assay have an epitope group specificity slightly different from those of the other three assays. This can explain why the correlations involving the Roche assay were weaker (r = 0.84-0.87) than those obtained with the other assays (r = 0.94-0.97). I conclude that agreement between the assays studied is as good as can be expected when different antibodies are used; nevertheless, consistent discrepancies between assays in several patients still necessitate the use of the same assay during follow-up.

HUMAN GASTRIC CANCER-ASSOCIATED ANTIGENS AND CARCINOEMBRYONIC ANTIGEN DETECTED BY MONOCLONAL ANTIBODIES

1983 ◽  
Vol 417 (1 Oncodevelopme) ◽  
pp. 158-168 ◽  
Author(s):  
Akira Yachi ◽  
Kohzoh Imai ◽  
Yasuo Moriya ◽  
Hideo Fujita ◽  
Mariko Tanda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Monoclonal Antibodies ◽  
Carcinoembryonic Antigen ◽  
Human Gastric Cancer

Diagnosis of gastric cancers with fluorescein-labeled monoclonal antibodies to carcinoembryonic antigen

1989 ◽  
Vol 9 (4) ◽  
pp. 422-426 ◽  
Author(s):  
Masaharu Tatsuta ◽  
Hiroyasu Iishi ◽  
Makoto Ichii ◽  
Miyako Baba ◽  
Reiko Yamamoto ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Carcinoembryonic Antigen ◽  
Gastric Cancers
Sign in / Sign up

Export Citation Format

Share Document