scholarly journals Management of Metastatic Bone Pain: Preliminary Results with Single Fraction (4 Gy) Radiotherapy

1989 ◽  
Vol 12 (1) ◽  
pp. 41-42 ◽  
Author(s):  
J.H. Karstens ◽  
B. Schnabel ◽  
J. Ammon
Keyword(s):  
Bone Pain ◽  
Single Fraction ◽  
Preliminary Results ◽  
Metastatic Bone Pain

scholarly journals Single fraction radiotherapy is more acceptable than multi-fraction radiotherapy to palliate the metastatic bone pain

2017 ◽  
Vol 45 (3) ◽  
pp. 151-155
Author(s):  
Sadia Sharmin ◽  
Md Zillur Rahman Bhuiyan ◽  
Atiar Rahman ◽  
Sarwar Alam
Keyword(s):  
Pain Relief ◽  
Bone Pain ◽  
Radiation Treatment ◽  
Symptom Relief ◽  
Complete Response ◽  
External Beam Radiation ◽  
Beam Radiation ◽  
Single Fraction ◽  
Significant Difference ◽  
Metastatic Bone Pain

One of the main goals of palliative radiation treatment is the relief of pain or dysfunction caused by the bone metastasis. Most patients achieve pain relief after irradiation. The striking clinical observation is that some patients experience symptom relief within 24hrs after the irradiation. This quasi experimental study was carried out in the department of Oncology, BSMMU from January 2014 to June 2014 with the intention to compare the role of single fraction and multiple fraction radiotherapy in the management of bone secondaries as regard as potency for pain relief. A total of 100 patients with age up to 70 years and of any sex having cytologically or histologically proven malignant diseases with the painful bone metastases in single or multiple sites without pathological fracture were selected for the study. They had no history of previous radiotherapy on the treatment site. Patients were divided in to two Arm A and Arm B with 50 patients in each arm. Arm A was treated with single (8 Gy) fraction radiotherapy and Arm B was treated with multiple fraction (30 Gy) radiotherapy i.e. 300 cGy per fraction in 10 fractions, 5 days a week for two weeks by telecobalt or orthovoltage machine. 44 patients in Arm A & 46 patients in Arm B completed the study. Onset of pain relief after completion of 4th week radiation were 68% in Arm A and 67.4% in Arm B . It was observed that, after 8th week of radiation 81.8% in Arm A and 86% in Arm B were relieved from pain. According to histological typing, 45% in Arm A & 52% patients in Arm B had complete response; 40% in Arm A & 37% patients in Arm B had partial response and overall distribution of no response of patient in Arm A was 18% and in Arm B was 7%. Metastatic bone pain represents one of the major indications in the external beam radiation therapy today.The disease can be efficiently treated by the use of either single fraction or multifraction radiotherapy without any significant difference in response to rate and early toxicities.Bangladesh Med J. 2016 Sep; 45 (3): 151-155

Low dose single fraction radiotherapy in the treatment of metastatic bone pain: A pilot study

1988 ◽  
Vol 12 (4) ◽  
pp. 297-300 ◽  
Author(s):  
P. Price ◽  
P.J. Hoskin ◽  
D. Easton ◽  
D. Austin ◽  
S. Palmer ◽  
...  
Keyword(s):  
Pilot Study ◽  
Bone Pain ◽  
Low Dose ◽  
Single Fraction ◽  
Metastatic Bone Pain

Metastatic bone pain palliation with 89‐Sr and 186‐Re‐HEDP in breast cancer patients

2001 ◽  
Vol 66 (2) ◽  
pp. 101-109 ◽  
Author(s):  
Rosa Sciuto ◽  
Anna Festa ◽  
Rosella Pasqualoni ◽  
Alessandro Semprebene ◽  
Sandra Rea ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Bone Pain ◽  
Pain Palliation ◽  
Breast Cancer Patients ◽  
Bone Pain Palliation ◽  
Metastatic Bone Pain

scholarly journals Sex-difference affects disease progression in the MRMT-1 model of cancer-induced bone pain

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 445
Author(s):  
Sarah Falk ◽  
Tamara Al-Dihaissy ◽  
Laura Mezzanotte ◽  
Anne-Marie Heegaard
Keyword(s):  
Mammary Cancer ◽  
Bone Pain ◽  
Pain Processing ◽  
Mammary Cells ◽  
In Vivo Models ◽  
Metastatic Bone Pain ◽  
Essential Parameter ◽  
Pain State ◽  
Males And Females

An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization of in vivo models in pain research. Mammary cancer cells are often used to model metastatic bone pain in vivo, and are commonly used in both males and females. Here we demonstrate that compared to males, females have an increased capacity for recovery following inoculation of MRMT-1 mammary cells, thus potentially causing a sex-dependent bias of the progression of the pain state.

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