Studies on Vitamin K-Dependent Factor Deficiency during Early Childhood with Special Reference to Prothrombin Activity and Antigen Level

1982 ◽  
Vol 11 (2) ◽  
pp. 90-95
Author(s):  
Yoshihiro Fujimura ◽  
Yoshiaki Mitnura ◽  
Seiji Kinoshita ◽  
Akira Yoshioka ◽  
Tathuo Kitawaki ◽  
...  
Keyword(s):  
Early Childhood ◽  
Special Reference ◽  
Vitamin K ◽  
Antigen Level ◽  
Prothrombin Activity ◽  
Factor Deficiency ◽  
Dependent Factor

Pathogenesis of Hemorrhage in Vitamin K Defieciency during Early Childhood with Special Reference to Prothrombin

1980 ◽  
Vol 22 (1) ◽  
pp. 73-73
Author(s):  
Yoshihiro Fujimura ◽  
Yoshiaki Mimura ◽  
Seiji Kinoshita ◽  
Kyoko Saito ◽  
Akira Yoshioka ◽  
...  
Keyword(s):  
Early Childhood ◽  
Special Reference ◽  
Vitamin K

Placental Transfer of Vitamin K1 and Its Implications in Fetal Hemostasis

1988 ◽  
Vol 60 (01) ◽  
pp. 039-043 ◽  
Author(s):  
L Mandelbrot ◽  
M Guillaumont ◽  
M Leclercq ◽  
J J Lefrère ◽  
D Gozin ◽  
...  
Keyword(s):  
Vitamin K ◽  
High Performance ◽  
Ultrasound Guidance ◽  
Placental Transfer ◽  
Vitamin K1 ◽  
Vitamin K Deficiency ◽  
Prothrombin Activity ◽  
Oral Supplementation ◽  
K Deficiency ◽  
The Mean

SummaryVitamin K status was evaluated using coagulation studies and/ or vitamin IQ assays in a total of 53 normal fetuses and 47 neonates. Second trimester fetal blood samples were obtained for prenatal diagnosis under ultrasound guidance. Endogenous vitamin K1 concentrations (determined by high performance liquid chromatography) were substantially lower than maternal levels. The mean maternal-fetal gradient was 14-fold at mid trimester and 18-fold at birth. Despite low vitamin K levels, descarboxy prothrombin, detected by a staphylocoagulase assay, was elevated in only a single fetus and a single neonate.After maternal oral supplementation with vitamin K1, cord vitamin K1 levels were boosted 30-fold at mid trimester and 60 fold at term, demonstrating placental transfer. However, these levels were substantially lower than corresponding supplemented maternal levels. Despite elevated vitamin K1 concentrations, supplemented fetuses and neonates showed no increase in total or coagulant prothrombin activity. These results suggest that the low prothrombin levels found during intrauterine life are not due to vitamin K deficiency.

scholarly journals Socio-Psychological Effects of Deviation: A Sociological Appraisal

2020 ◽  
Keyword(s):  
Social Sciences ◽  
Social Psychology ◽  
Early Childhood ◽  
Special Reference ◽  
Human Behavior ◽  
Psychological Effects ◽  
Biological Factors ◽  
Childhood Experiences ◽  
Prejudice And Discrimination ◽  
Global World

The paper explores how people think and behave. However, various schools of thought have evolved through the development of social psychology on human behavior. While such scientists attribute a certain behavior to biological factors such as genetics, others consider early childhood experiences to be more likely affecting behavior. Such approaches or perspectives largely need investigations with special reference to the current global world. Concepts such as social influence, attribution, prejudice and discrimination, attitudes etc. play role here. The paper investigates why deviance occurs? How does it affect a society? However, since the early days of society, scholars have developed theories to explore what deviance and crime mean to society. Deviance being an accidental result of disorder and anomie, and a symptom of internal breakdown, it usually leads to crime. Method of research used in the present research is of qualitative type which is very popular in social sciences. Conclusion reaches the result that due to the unbridled and increasing urbanization and the emergence of a controversial society, deviation of socio-psychological norms is inevitable.

scholarly journals Exon 2 skipping eliminates γ‐glutamyl carboxylase activity, indicating a partial splicing defect in a patient with vitamin K clotting factor deficiency

2019 ◽  
Vol 17 (7) ◽  
pp. 1053-1063
Author(s):  
Mark A. Rishavy ◽  
Kevin W. Hallgren ◽  
Haitao Zhang ◽  
Kurt W. Runge ◽  
Kathleen L. Berkner
Keyword(s):  
Vitamin K ◽  
Clotting Factor ◽  
Carboxylase Activity ◽  
Exon 2 ◽  
Splicing Defect ◽  
Factor Deficiency

scholarly journals The impact of vitamin K-dependent factor depletion by warfarin on platelet-rich thrombosis after deep arterial injury

2004 ◽  
Vol 2 (10) ◽  
pp. 1834-1841 ◽  
Author(s):  
R. D. Mcbane Ii ◽  
N. L. Hassinger ◽  
D. E. Grill ◽  
J. H. Chesebro
Keyword(s):  
Vitamin K ◽  
Arterial Injury ◽  
The Impact ◽  
Dependent Factor

scholarly journals Coagulation disorders during treatment with cefazolin and rifampicin: rare but dangerous

2021 ◽  
Vol 6 (5) ◽  
pp. 131-134
Author(s):  
Ines Kouki ◽  
Clémence Montagner ◽  
Wladimir Mauhin ◽  
Jonathan London ◽  
Thierry Lazard ◽  
...  
Keyword(s):  
Prothrombin Time ◽  
Vitamin K ◽  
Clotting Factor ◽  
Severe Bleeding ◽  
Coagulation Disorders ◽  
Severe Vitamin ◽  
Digestive Hemorrhage ◽  
Factor Deficiency

Abstract. We describe a 79-year-old man with spondylodiscitis and unknown pathogen, treated with cefazolin and rifampicin. He developed a massive digestive hemorrhage. Prothrombin time was prolonged with severe vitamin-K-dependent clotting-factor deficiency. Severe bleeding can occur during cefazolin and rifampicin use. This deficiency should be assessed before prescribing cefazolin–rifampicin and prothrombin time monitored.

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