scholarly journals Census and Taking-Over from the Point of View of Transfusion and Derivatives of Haemophiliacs from Oran and Its Area

1981 ◽  
Vol 10 (1) ◽  
pp. 224-224
Author(s):  
M.B. Mansour ◽  
M. Benali
Keyword(s):  
Point Of View ◽  
Derivatives Of

Some 2-substituted derivatives of 5-(2-amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl)pentanoic acid

1981 ◽  
Vol 46 (6) ◽  
pp. 1397-1404 ◽  
Author(s):  
Rudolf Kotva ◽  
Jiří Křepelka ◽  
Antonín Černý ◽  
Vojtěch Pujman ◽  
Miroslav Semonský
Keyword(s):  
Point Of View ◽  
Pentanoic Acid ◽  
Antineoplastic Effect ◽  
Derivatives Of

On condensation of 6-substituted trialkyl esters of 2-carboxy-1,7-heptanedioic acids XIII-XXIII with guanidineand subsequent saponification 2-substituted 5-(2-amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl)pentanoic acids II-XII were prepared. From the pharmacological point of view some of the substances prepared had a potentiating effect on the antileukemia effect of 5-fluorouracil in mice and the antineoplastic effect manifested by a diminution of the tumours in animals with experimental tumours.

scholarly journals DFT Visualization and Experimental Evidence of BHT-Mg-Catalyzed Copolymerization of Lactides, Lactones and Ethylene Phosphates

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1641 ◽  
Author(s):  
Ilya Nifant’ev ◽  
Andrey Shlyakhtin ◽  
Maxim Kosarev ◽  
Dmitry Gavrilov ◽  
Stanislav Karchevsky ◽  
...  
Keyword(s):  
Ring Opening ◽  
Density Functional ◽  
Point Of View ◽  
Basis Set ◽  
Random Copolymers ◽  
Key Factors ◽  
Functional Theory ◽  
Cyclic Esters ◽  
Dft Modeling ◽  
Derivatives Of

Catalytic ring-opening polymerization (ROP) of cyclic esters (lactides, lactones) and cyclic ethylene phosphates is an effective way to process materials with regulated hydrophilicity and controlled biodegradability. Random copolymers of cyclic monomers of different chemical nature are highly attractive due to their high variability of characteristics. Aryloxy-alkoxy complexes of non-toxic metals such as derivatives of 2,6-di-tert-butyl-4-methylphenoxy magnesium (BHT-Mg) complexes are effective coordination catalysts for homopolymerization of all types of traditional ROP monomers. In the present paper, we report the results of density functional theory (DFT) modeling of BHT-Mg-catalyzed copolymerization for lactone/lactide, lactone/ethylene phosphate and lactide/ethylene phosphate mixtures. ε-Caprolactone (ε-CL), l-lactide (l-LA) and methyl ethylene phosphate (MeOEP) were used as examples of monomers in DFT simulations by the Gaussian-09 program package with the B3PW91/DGTZVP basis set. Both binuclear and mononuclear reaction mechanistic concepts have been applied for the calculations of the reaction profiles. The results of calculations predict the possibility of the formation of random copolymers based on l-LA/MeOEP, and substantial hindrance of copolymerization for ε-CL/l-LA and ε-CL/MeOEP pairs. From the mechanistic point of view, the formation of highly stable five-membered chelate by the products of l-LA ring-opening and high donor properties of phosphates are the key factors that rule the reactions. The results of DFT modeling have been confirmed by copolymerization experiments.

Bonding of Rubber to Metal by Means of New Chemical Derivatives of Rubber

1950 ◽  
Vol 23 (1) ◽  
pp. 281-291 ◽  
Author(s):  
Jacques Gossot
Keyword(s):  
Ph Value ◽  
Chemical Reactivity ◽  
Point Of View ◽  
Physical Point ◽  
General Application ◽  
Chemical Derivatives ◽  
Special Cases ◽  
Practical Standpoint ◽  
In Virtue Of ◽  
Derivatives Of

Abstract The bonding process which has been described is of general application to all types of rubber mixtures, to metals, and to various other materials, without any change in composition of the bonding agent for the different materials. Although the problem of adhesion has been approached in this work only from the purely practical standpoint, it should be realized how little progress has been made in the theoretical knowledge of the problem. As a matter of fact, only a few authors have attempted to explain, on a basis of general concepts, certain special cases of adhesion, and there is still no real insight into the problem as a whole which might open the way to material progress. If one turns to the works of MacBain, Delmonte, and Buchan among the most important contributions to the phenomena of adhesion, the ultimate conclusion must be drawn that little has been accomplished in orienting investigations in this field toward more productive ends. From the physical point of view, particular attention must be paid to the condition of the state of the surface of the material to be bonded, to the surface tension, to the viscosity, and to the pH value of the adhesive. The chemical structure of the latter is that of a long-chain compound and, as has been proved conclusively in the present investigation, certain groups play a fundamental role, both in virtue of their chemical reactivity, and in virtue of the polar moment which they confer upon the molecule.

scholarly journals Hydroxyderivatives of levoglucosenone in reactions of enantioselective reduction of 1,3-diphenylpropan-1-one

2020 ◽  
Vol 63 (9) ◽  
pp. 19-25
Author(s):  
Anna N. Davydova ◽  
◽  
Bulat T. Sharipov ◽  
Farid A. Valeev ◽  
◽  
...  
Keyword(s):  
Aluminum Hydride ◽  
Point Of View ◽  
Chiral Ligands ◽  
Lithium Aluminum ◽  
Hydrogen Atoms ◽  
Enantioselective Reduction ◽  
Urgent Task ◽  
Partial Neutralization ◽  
Prochiral Ketones ◽  
Derivatives Of

The enantioselective reduction of prochiral ketones is an important method for the preparation of enanti-enriched secondary alcohols, which can serve as starting materials for optically active compounds. Chiral metal hydride reagents, such as lithium aluminum hydride (LiAlH4) and sodium borohydride (NaBH4), modified with chiral ligands, have been developed to effect enantioselective reduction. However, in most cases, derivatives are used to obtain chiral hydride reagents, which are rare and hardly available. Therefore, the search for more accessible and effective derivatives suitable for the modification of hydride reagents is an urgent task. Levoglucosenone is an optically pure enone of carbohydrate nature, readily available by pyrolysis of any cellulose-containing materials. Levoglucosenone is considered a promising bioplatform for both laboratory synthesis and industrial use. The prospect of the development of chemistry of levoglucosenone and its derivatives in industry makes it possible to pay attention to these compounds from the point of view of studying their possibilities as chiral inducers or auxiliaries. In this work, we studied the possibilities of chiral induction in the reduction reactions of 1,3-diphenylpropan-1-one with hydride reagents obtained by replacing hydrogens in LiAlH4 and NaBH4 with hydroxy derivatives of levoglucosenone. The reduction of 1,3-diphenylpropan-1-one with chiral aluminum hydride reagents proceeded with low enantioselectivity, mainly with a predominance of (S)-1,3-diphenylpropan-1-ol. It was found that the enantiomeric purity of the S-stereomer decreases with an increase in the substitution of hydrogen atoms in LiAlH4 by hydroxy derivatives of levoglucosenone. Reduction of 1,3-diphenylpropan-1-one with reagents obtained by partial neutralization of NaBH4 with hydroxy derivatives of levoglucosenone, on the contrary, predominantly leads to the formation of (R)-1,3-diphenylpropan-1-ol. The addition of AcOH and Bu4NCl to NaBH4 has a positive effect on the optical frequency of the R-alcohol. At the same time, enantioselectivity in the reactions was almost absent upon reduction of 1,3-diphenylpropan-1-one with reagents obtained by partial neutralization of BH3. The best results of enantioselective reduction were shown by unsaturated alcohols: (1S,4S,5R) -6,8-dioxabicyclo[3.2.1]oct-2-en-4-ol and (1S,4S,5R)-4-methyl-6,8-dioxabicyclo[3.2.1]oct-2-en-4-ol, of which (1S,4S,5R)-6,8-dioxabicyclo[3.2.1]oct-2-en-4-ol was the most effective. It is likely that an increase in the enantioselectivity of reactions carried out in the presence of hydroxy derivatives of levoglucosenone is possible by obtaining more bulky chiral ligands, provided that the double bond is retained.

scholarly journals Once More on the Etymology of the Russian Word Mazurik ‘Cheater’ (in Light of the Cultural and Linguistic Image of Mazur in Slavic Traditions)

Slovene ◽  
2017 ◽  
Vol 6 (1) ◽  
pp. 413-448
Author(s):  
Elena L. Berezovich ◽  
Valeria S. Kuchko
Keyword(s):  
Close Contact ◽  
Word Formation ◽  
Point Of View ◽  
Negative Image ◽  
Source Language ◽  
North East ◽  
The North ◽  
Using Data ◽  
Derivatives Of ◽  
Different Origin

The article proves the hypothesis of the origin of the Russian colloquial word mazurik as deriving from the name of the Polish ethnographic group mazury ‘Mazurs’—inhabitants of Mazovia (in central and south-eastern Poland) as well as immigrants from this area to other places, mainly in the north-east. This hypothesis had previously been stated in the literature, but it had not been demonstrated rigorously. The authors show that the word mazurik is included in the big semantic word family that is derived from mazur, by studies focused on nationwide usage and through dialects. Using data from the lexical system and from folklore, the linguistic portrait of the Mazurs in the Russian tradition is reconstructed, and it is compared with linguistic stereotypes of the Mazurs in the source language (Polish) and the languages of peoples in close contact with the Mazurs (Ukrainian and Belarusian). The main features of these portraits are the same in these languages, and they create a negative image of the Mazur in the Slavic tradition, making the “Polish” etymological version semantically legitimate. In addition, the authors prove this hypothesis from the point of view of word formation, linguogeography, and sociolinguistic characteristics of the words under consideration. It is noted that the derivatives of the word family derived from mazur are attracted to the lexemes which have similar form and meaning but different origin, in particular, to derivatives of the verb mazatʹ and the words murza and zamurzannyi. The article contains an overview with commentary of hypotheses about the origin of the Russian mazurik existing in Slavic etymological literature.

Further Observations on Sodium Amytal Experiments

1942 ◽  
Vol 88 (370) ◽  
pp. 122-126
Author(s):  
F. Reitmann
Keyword(s):  
Barbituric Acid ◽  
Point Of View ◽  
Special Position ◽  
Catatonic Schizophrenia ◽  
Derivatives Of

Derivatives of barbituric acid are in general sedatives, hypnotics and analgesics, but sodium amytal (S.A.) occupies a special position, because of its effect on certain mental and nervous conditions. It produces transient amelioration in catatonic schizophrenia and hypnosis-like conditions in neuroses. The latter is important through the fact that one is able to study hypnosis from a different pharmacological point of view.

The Effects of Some Bis - 1, 2, 4 - Triazole Containing Aminomethyl Derivatives on MDA Levels and Vitamins in Tissues of Rats

2019 ◽  
Vol 41 (4) ◽  
pp. 707-707
Author(s):  
Naci Omer Alayunt Naci Omer Alayunt ◽  
Mustafa Karatepe Mustafa Karatepe ◽  
Akif Evren Parlak Akif Evren Parlak ◽  
Mustafa Ulas Mustafa Ulas ◽  
Semra Turkoglu Sevgi Durna Dastan Semra Turkoglu Sevgi Durna Dastan ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antimicrobial Agents ◽  
Antioxidant Activities ◽  
Point Of View ◽  
Antioxidant Vitamins ◽  
Current Investigation ◽  
Drug Candidates ◽  
Extensive Range ◽  
Aminomethyl Derivatives ◽  
Derivatives Of

It was reported that the 1, 2, 4-triazole and the derivatives of this compound demonstrate numerous activities in a pharmacological point of view. 1, 2, 4-Triazole moieties were employed in an extensive range of drug candidates, which are therapeutically promising and include anti-inflammatories, anti-anxiety compounds, sedatives, CNS stimulants, antimicrobial agents, and antimycotic ones such as intraconazole, fluconazole and voriconazole. In the current investigation, several aminomethyl derivatives, which contain bis-1, 2, 4-triazole, were newly synthesized and their impacts on the levels of antioxidant vitamins (A, C and E) and malondialdehyde (MDA) were examined in serum, kidney and liver of rats. The investigation of the levels of the vitamins (A, C and E) and malondialdehyde (MDA) were performed by calculations in HPLC system. In the study, the observed antioxidant activity revealed that all the analyzed compounds, have promising antioxidant activities, which may be the result of the presence of benzylpiperazine and dipropylamine, and a methylpiperidine moiety as well as the allyl group. Therefore, it was concluded that ample scope exists for further studies.

Infrared spectra of 2,4-dinitro and 2,6-dinitroaniline derivatives

1982 ◽  
Vol 47 (4) ◽  
pp. 1100-1111 ◽  
Author(s):  
Jaroslav Majer ◽  
Vladimír Kadeřábek
Keyword(s):  
Absorption Spectra ◽  
Infrared Spectra ◽  
Infrared Absorption ◽  
Point Of View ◽  
Amino Groups ◽  
Infrared Absorption Spectra ◽  
Derivatives Of

Infrared absorption spectra of N-substituted derivatives of 2,4-dinitro- and 2,6-dinitroanilines have been measured and interpreted from the point of view of bond and sterical interactions of the substituted amino groups with the both nitro groups.

scholarly journals BROMINATION OF AROMATIC AMINES

2019 ◽  
Vol 62 (4) ◽  
pp. 47-59
Author(s):  
Fatima A. Mustafayeva ◽  
Najaf T. Kakhramanov
Keyword(s):  
Aromatic Amines ◽  
Hydrogen Bromide ◽  
Point Of View ◽  
Molar Ratio ◽  
Ammonium Bromide ◽  
Solvent Free Conditions ◽  
Environmentally Safe ◽  
Bromination Reaction ◽  
Radiation Conditions ◽  
Derivatives Of

It is known that the antipyrenes, biological active substances (antitumor, antibacterial, antifungal, antiviral), pharmacological preparations on the basis of bromine-containing aromatic compounds are widely used in the industry. Considering this and increased demand for these substances the purpose of this work was to summarize and systematize the accumulated knowledge in this area. The article presents methods and reagent systems used in the bromination of aromatic amines. There have been described the bromination of aromatic amines with hydrogen bromide, sodium bromide, potassium bromide, ammonium bromide, copper (II) bromide, N-bromosuccinimide, N-bromosaccharin, polymer-supported halogenation agents, and difference of these methods from the point of view of the used oxidizer, the medium and the solvent, the catalyst, the regioselectivity, the quantity of bromine atoms in the obtained product. The influence of solvents, catalysts, the nature (electron-donor or electron-acceptor) and position (ortho-, meta-, para-) of the substituents in the aromatic ring, reaction conditions, molar ratio of the reagents, reaction temperature and carrying out time of bromination reaction of aromatic amines has been shown. The bromination reactions courses of aromatic amines in different solvents, in solvent free conditions, in solid states has been described. The bromination of aromatic amines under thermal, microwave, ultraviolet radiation conditions has been studied. In the paper the regioselective monobromination and also obtaining of di-, tri- bromo derivatives of aromatic amines has been shown. Taking into account today's priority to environmentally safe methods of bromination of aromatic amines they have been also mentioned. Given the above, in our opinion, the information presented in this article will help to optimize the production of bromo derivatives of aromatic amines used in industry, technics and technology.

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