An Investigation of the Relationship between Free Radical Activity and Vitamin C Metabolism in Elderly Diabetic Subjects with Retinopathy

Gerontology ◽  
1992 ◽  
Vol 38 (5) ◽  
pp. 268-274 ◽  
Author(s):  
A.J. Sinclair ◽  
A.J. Girling ◽  
L. Gray ◽  
J. Lunec ◽  
A.H. Barnett
Keyword(s):  
Free Radical ◽  
Vitamin C ◽  
C Metabolism ◽  
The Relationship ◽  
Free Radical Activity

PERBANDINGAN METODE EKSTRAKSI MASERASI DAN SOKLETASI TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN JAMBU BOL (Syzygium malaccense L.)

2017 ◽  
Vol 3 (1) ◽  
pp. 91
Author(s):  
Henny Nurhasnawati ◽  
Sukarmi Sukarmi ◽  
Fitri Handayani
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Vitamin C ◽  
Extraction Methods ◽  
Natural Antioxidant ◽  
Comparison Of Methods ◽  
Activity Test ◽  
Ic50 Value ◽  
The Difference ◽  
Free Radical Activity

Malay apple (Syzygium malaccense L.) is a plant that can be used for treatment. Antioxidants have the activity to reduce free radical compounds which is one of the causes of the emergence of various diseases in humans. The purpose of this study to determine the comparison of methods of maceration and socletation extraction of antioxidant activity of malay apple leaf. Research stages include sampling, plant determination, making of simplisia, maceration extraction and socletation with 70% ethanol solvent and determine the antioxidant activity by UV-Vis spectrophotometry with DPPH (1,1-diphenyl-2-picrylhydrazyl) as free radical. The parameter is IC50 value that is the concentration of antioxidant compound which can cause 50% loss of DPPH free radical activity. Although both methods show very strong antioxidant activity, it can be concluded that the difference in extraction methods has an effect on the antioxidant activity produced. The results of antioxidant activity test showed that socletation methods gave an average IC50 value of 37.67 ppm, this value is higher than maceration methods with an average IC50 value of 47.80 ppm. Malay apple leaf has the potential as a natural antioxidant, although it has a lower IC50 value than vitamin C which is 9.72 ppm.

The Relationship Between Antioxidant Nutrient Intake and Cataracts in Older People

2006 ◽  
Vol 76 (6) ◽  
pp. 359-366 ◽  
Author(s):  
Rodríguez-Rodríguez ◽  
Ortega ◽  
López-Sobaler ◽  
Aparicio ◽  
Bermejo ◽  
...  
Keyword(s):  
Vitamin C ◽  
Older People ◽  
Dietary Intake ◽  
Protective Effect ◽  
Elderly People ◽  
Nutrient Intake ◽  
Institutionalized Elderly ◽  
Weighing Method ◽  
The Relationship

This study investigated the relationship between the intake of antioxidant nutrients and the suffering of cataracts in 177 institutionalized elderly people (61 men and 116 women) aged ≥ 65 years. Dietary intake was monitored for 7 consecutive days using a "precise individual weighing" method. Subjects, who during their earlier years were exposed by their work to sunlight, had a greater risk of suffering cataracts (OR = 3.2; Cl: 1.1–9.3, P < 0.05) than those who worked indoors. A relationship was found between increased vitamin C intake and a reduced prevalence of cataracts (i.e., when comparing those above P95 for vitamin C intake with those below P5; (OR = 0.08; Cl: 0.01–0.75, P 0.05). Among subjects with cataracts, 12.1% had vitamin C intakes of < 61 mg/day (P10) and only 2.2% had intakes of > 183 mg/day (P95) (p < 0.01). Subjects who consumed > 3290 μg/day (P95) of lutein were less likely to have cataracts (OR = 0.086; Cl: 0.007–1.084; p < 0.05) than those whose consumption was < 256 μg/day (P5). In men, high intakes of zeaxanthin seemed to provide a protective effect against the problem (OR = 0.96; Cl: 0.91–0.99; p < 0.05). The results suggest an association exists between exposure to sunlight and the development of cataracts, and that vitamin C, lutein, and zeaxanthin offer some protection against this disorder.

Free radical activity and hemostatic factors in NIDDM patients with and without microalbuminuria

Diabetes ◽  
1992 ◽  
Vol 41 (8) ◽  
pp. 909-913 ◽  
Author(s):  
A. Collier ◽  
A. Rumley ◽  
A. G. Rumley ◽  
J. R. Paterson ◽  
J. P. Leach ◽  
...  
Keyword(s):  
Free Radical ◽  
Hemostatic Factors ◽  
Free Radical Activity ◽  
Niddm Patients

Octadeca-9,11 Dienoic Acid - a Measurement of free Radical Activity or a Marker of Infection in the Lung?

1991 ◽  
Vol 81 (s25) ◽  
pp. 17P-17P ◽  
Author(s):  
CIA Jack ◽  
MJ Jackson ◽  
E Ridgeway ◽  
CRK Hind
Keyword(s):  
Free Radical ◽  
Dienoic Acid ◽  
Free Radical Activity

Free-radical activity after primary coronary angioplasty in acute myocardial infarction

1994 ◽  
Vol 127 (6) ◽  
pp. 1443-1449 ◽  
Author(s):  
Ever D. Grech ◽  
Christopher M. Bellamy ◽  
Malcolm J. Jackson ◽  
Ronald A. Muirhead ◽  
E.Brian Faragher ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Free Radical ◽  
Coronary Angioplasty ◽  
Primary Coronary Angioplasty ◽  
Free Radical Activity

scholarly journals Prevalence of Hypovitaminosis C and its Relationship with Frailty in Older Hospitalised Patients: A Cross-Sectional Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2117
Author(s):  
Yogesh Sharma ◽  
Alexandra Popescu ◽  
Chris Horwood ◽  
Paul Hakendorf ◽  
Campbell Thompson
Keyword(s):  
Vitamin C ◽  
Cross Sectional Study ◽  
Multivariate Logistic Regression Model ◽  
Cross Sectional ◽  
Vitamin C Deficiency ◽  
Frailty Assessment ◽  
Geriatric Unit ◽  
Hospitalised Patients ◽  
Micronutrient Malnutrition ◽  
The Relationship

Frailty is common in older hospitalised patients and may be associated with micronutrient malnutrition. Only limited studies have explored the relationship between frailty and vitamin C deficiency. This study investigated the prevalence of vitamin C deficiency and its association with frailty severity in patients ≥75 years admitted under a geriatric unit. Patients (n = 160) with a mean age of 84.4 ± 6.4 years were recruited and underwent frailty assessment by use of the Edmonton Frail Scale (EFS). Patients with an EFS score <10 were classified as non-frail/vulnerable/mildly frail and those with ≥10 as moderate–severely frail. Patients with vitamin C levels between 11–28 μmol/L were classified as vitamin C depleted while those with levels <11 μmol/L were classified as vitamin C deficient. A multivariate logistic regression model determined the relationship between vitamin C deficiency and frailty severity after adjustment for various co-variates. Fifty-seven (35.6%) patients were vitamin C depleted, while 42 (26.3%) had vitamin C deficiency. Vitamin C levels were significantly lower among patients who were moderate–severely frail when compared to those who were non-frail/vulnerable/mildly frail (p < 0.05). After adjusted analysis, vitamin C deficiency was 4.3-fold more likely to be associated with moderate–severe frailty (aOR 4.30, 95% CI 1.33-13.86, p = 0.015). Vitamin C deficiency is common and is associated with a greater severity of frailty in older hospitalised patients.

scholarly journals Antioxidant/Oxidant Status and Cardiac Function in Bradykinin B1- and B2-Receptor Null Mice

2013 ◽  
pp. 511-517 ◽  
Author(s):  
S. DELEMASURE ◽  
N. BLAES ◽  
C. RICHARD ◽  
R. COUTURE ◽  
M. BADER ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Cardiovascular Diseases ◽  
Vitamin C ◽  
Cardiac Function ◽  
Cardiac Phenotype ◽  
Plasma Antioxidant Capacity ◽  
Ascorbyl Free Radical ◽  
Plasma Antioxidant ◽  
Oxidant Status

Kinin-vasoactive peptides activate two G-protein-coupled receptors (R), B1R (inducible) and B2R (constitutive). Their complex role in cardiovascular diseases could be related to differential actions on oxidative stress. This study investigated impacts of B1R or B2R gene deletion in mice on the cardiac function and plasma antioxidant and oxidant status. Echocardiography-Doppler was performed in B1R (B1R-/-) and B2R (B2R-/-) deficient and wild type (WT) adult male mice. No functional alteration was observed in B2R-/- hearts. B1R-/- mice had significantly lowered fractional shortening and increased isovolumetric contraction time. The diastolic E and A waves velocity ratio was similar in all mice groups. Thus B1R-/- mice provide a model of moderate systolic dysfunction, whereas B2R-/- mice displayed a normal cardiac phenotype. Plasma antioxidant capacity (ORAC) was significantly decreased in both B1R-/- and B2R-/- mice whereas the vitamin C levels were decreased in B2R-/- mice only. Plasma ascorbyl free radical was significantly higher in B1R-/- compared to WT and B2R-/- mice. Therefore, the oxidative stress index, ascorbyl free radical to vitamin C ratio, was increased in both B1R-/- and B2R-/- mice. Hence, B1R and B2R deficiency are associated with increased oxidative stress, but there is a differential imbalance between free radical production and antioxidant defense. The interrelationship between the differential B1R and B2R roles in oxidative stress and cardiovascular diseases remain to be investigated.

scholarly journals Aktivitas Antioksidan dan Kandungan Komponen Bioaktif Sari Buah Namnam

2015 ◽  
pp. 130-136 ◽  
Author(s):  
Adawiah Adawiah ◽  
Dede Sukandar ◽  
Anna Muawanah
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Vitamin C ◽  
Oxidative Reaction ◽  
High Antioxidant Activity

Antioxidant is a compoud  inhibit that have an important role in protecting health due to it can absorb free radical molecules and inhibit oxidative reaction which cause anykinds of diseases. This study aims to determine the chemical compositition and antioxidant  activity of namnam juice, characteristic of namnam. In this experimental, proximat analysis, TPC, TFC, Vitamin C, antioxidant activity were evaluated. Namnam juice contains 996.03 mg/L of phenolics, 421.09 mg/Lof flavonoids, 121.44 mg/100mL of vitamin C and high antioxidant activity with IC50 5µL/mL.DOI :http://dx.doi.org/10.15408/jkv.v0i0.3155.

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