Exercise Intensity-Dependent Changes in the Inflammatory Response in Sedentary Women: Role of Neuroendocrine Parameters in the Neutrophil Phagocytic Process and the Pro-/Anti-Inflammatory Cytokine Balance

2009 ◽  
Vol 16 (4) ◽  
pp. 237-244 ◽  
Author(s):  
E. Giraldo ◽  
J.J. Garcia ◽  
M.D. Hinchado ◽  
E. Ortega
Keyword(s):  
Inflammatory Response ◽  
Exercise Intensity ◽  
Inflammatory Cytokine ◽  
Phagocytic Process ◽  
Cytokine Balance ◽  
Anti Inflammatory ◽  
Sedentary Women ◽  
Anti Inflammatory Cytokine

A similar pro/anti-inflammatory cytokine balance is present in the airways of competitive athletes and non-exercising asthmatics

2018 ◽  
Vol 63 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Marcin Kurowski ◽  
Janusz Jurczyk ◽  
Agnieszka Olszewska-Ziąber ◽  
Marzanna Jarzębska ◽  
Hubert Krysztofiak ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Cytokine Balance ◽  
Competitive Athletes ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

scholarly journals Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy

2007 ◽  
Vol 2007 ◽  
pp. 1-6 ◽  
Author(s):  
Levent Sutcigil ◽  
Cagatay Oktenli ◽  
Ugur Musabak ◽  
Ali Bozkurt ◽  
Adnan Cansever ◽  
...  
Keyword(s):  
Major Depression ◽  
Inflammatory Cytokines ◽  
Antidepressant Treatment ◽  
Depression Effect ◽  
Immunomodulatory Effects ◽  
Cytokine Balance ◽  
Anti Inflammatory ◽  
Time Of Admission ◽  
Anti Inflammatory Cytokine

The specific associations between antidepressant treatment and alterations in the levels of cytokines remain to be elucidated. In this study, we aimed to explore the role of IL-2, IL-4, IL-12, TNF-α, TGF-β1, and MCP-1 in major depression and to investigate the effects of sertraline therapy. Cytokine and chemokine levels were measured at the time of admission and 8 weeks after sertraline treatment. Our results suggest that the proinflammatory cytokines (IL-2, IL-12, and TNF-α) and MCP-1 were significantly higher, whereas anti-inflammatory cytokines IL-4 and TGF-β1 were significantly lower in patients with major depression than those of healthy controls. It seems likely that the sertraline therapy might have exerted immunomodulatory effects through a decrease in the proinflammatory cytokine IL-12 and an increase in the anti-inflammatory cytokines IL-4 and TGF-β1. In conclusion, our results indicate that Th1-, Th2-, and Th3-type cytokines are altered in the depressed patients and some of them might have been corrected by sertraline treatment.

scholarly journals Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1β

2008 ◽  
Vol 294 (4) ◽  
pp. E709-E718 ◽  
Author(s):  
Klemen Strle ◽  
Robert H. McCusker ◽  
Rodney W. Johnson ◽  
Samantha M. Zunich ◽  
Robert Dantzer ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Muscle Wasting ◽  
Inflammatory Responses ◽  
Mapk Signaling ◽  
Protective Role ◽  
Igf I ◽  
Anti Inflammatory ◽  
Kinase Pathway ◽  
Anti Inflammatory Cytokine

Prolonged and excessive inflammation is implicated in resistance to the biological actions of IGF-I and contributes to the pathophysiology of neurodegenerative, metabolic, and muscle-wasting disorders. IL-10 is a critical anti-inflammatory cytokine that restrains inflammatory responses in macrophages and T cells by inhibiting cytokine and chemokine synthesis and reducing expression of their receptors. Here we demonstrate that IL-10 plays a protective role in nonhematopoietic cells by suppressing the ability of exogenous IL-1β to inhibit IGF-I-induced myogenin and myosin heavy chain expression in myoblasts. This action of IL-10 is not caused by impairment of IL-1β-induced synthesis of IL-6 or the ability of IL-1β to activate two members of the MAPK family, ERK1/2 and p38. Instead, this newly defined protective role of IL-10 occurs by specific reversal of IL-1β activation of the JNK kinase pathway. IL-10 blocks IL-1β-induced phosphorylation of JNK, but not ERK1/2 or p38, indicating that only the JNK component of the IL-1β-induced MAPK signaling pathway is targeted by IL-10. This conclusion is supported by the finding that a specific JNK inhibitor acts similarly to IL-10 to restore IGF-I-induced myogenin expression, which is suppressed by IL-1β. Collectively, these data demonstrate that IL-10 acts in a novel, nonclassical, protective manner in nonhematopoietic cells to inhibit the IL-1β receptor-induced JNK kinase pathway, resulting in prevention of IGF-I resistance.

scholarly journals Pro- and Anti-Inflammatory Cytokines Release in Mice Injected withCrotalus durissus terrificusVenom

2008 ◽  
Vol 2008 ◽  
pp. 1-10 ◽  
Author(s):  
A. Hernández Cruz ◽  
S. Garcia-Jimenez ◽  
R. Zucatelli Mendonça ◽  
V. L. Petricevich
Keyword(s):  
Inflammatory Cytokines ◽  
Inflammatory Mediators ◽  
Inflammatory Cytokine ◽  
Time Course ◽  
Dependent Manner ◽  
Blood Biochemical ◽  
Cytokine Balance ◽  
Anti Inflammatory ◽  
Crotalus Durissus ◽  
Anti Inflammatory Cytokine

The effects ofCrotalus durissus terrificusvenom (Cdt) were analyzed with respect to the susceptibility and the inflammatory mediators in an experimental model of severe envenomation. BALB/c female mice injected intraperitoneally presented sensibility to Cdt, with changes in specific signs, blood biochemical and inflammatory mediators. The venom induced reduction of glucose and urea levels and an increment of creatinine levels in serum from mice. Significant differences were observed in the time-course of mediator levels in sera from mice injected with Cdt. The maximum levels of IL-6, NO, IL-5, TNF, IL-4 and IL-10 were observed 15 min, 30 min, 1, 2 and 4 hours post-injection, respectively. No difference was observed for levels of IFN-γ. Taken together, these data indicate that the envenomation by Cdt is regulated both pro- and anti-inflammatory cytokine responses at time-dependent manner. In serum from mice injected with Cdt at the two first hours revealed of pro-inflammatory dominance. However, with an increment of time an increase of anti-inflammatory cytokines was observed and the balance toward to anti-inflammatory dominance. In conclusion, the observation that Cdt affects the production of pro- and anti-inflammatory cytokines provides further evidence for the role played by Cdt in modulating pro/anti-inflammatory cytokine balance.

Proinflammatory and Anti-Inflammatory Cytokine Balance in Gasoline Exhaust Induced Pulmonary Injury in Mice

2005 ◽  
Vol 17 (3) ◽  
pp. 161-168 ◽  
Author(s):  
Veerapandian Sureshkumar ◽  
Bholanath Paul ◽  
Mani Uthirappan ◽  
Renu Pandey ◽  
Anand Prakash Sahu ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Pulmonary Injury ◽  
Cytokine Balance ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

scholarly journals The anti-inflammatory cytokine response characterized by elevated interleukin-10 is a stronger predictor of severe disease and poor outcomes than the pro-inflammatory cytokine response in coronavirus disease 2019 (COVID-19)

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Brandon Michael Henry ◽  
Stefanie W. Benoit ◽  
Jens Vikse ◽  
Brandon A. Berger ◽  
Christina Pulvino ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Lymphocyte Count ◽  
Inflammatory Cytokine ◽  
Severe Disease ◽  
Interleukin 10 ◽  
Cytokine Response ◽  
Inflammatory Cytokine Response ◽  
Anti Inflammatory ◽  
Poor Outcomes ◽  
Anti Inflammatory Cytokine

AbstractObjectivesSevere coronavirus disease 2019 (COVID-19) is associated with a dysregulated immune state. While research has focused on the hyperinflammation, little research has been performed on the compensatory anti-inflammatory response. The aim of this study was to evaluate the anti-inflammatory cytokine response to COVID-19, by assessing interleukin-10 (IL-10) and IL-10/lymphocyte count ratio and their association with outcomes.MethodsAdult patients presenting to the emergency department (ED) with laboratory-confirmed COVID-19 were recruited. The primary endpoint was maximum COVID-19 severity within 30 days of index ED visit.ResultsA total of 52 COVID-19 patients were enrolled. IL-10 and IL-10/lymphocyte count were significantly higher in patients with severe disease (p<0.05), as well as in those who developed severe acute kidney injury (AKI) and new positive bacterial cultures (all p≤0.01). In multivariable analysis, a one-unit increase in IL-10 and IL-10/lymphocyte count were associated with 42% (p=0.031) and 32% (p=0.013) increased odds, respectively, of severe COVID-19. When standardized to a one-unit standard deviations scale, an increase in the IL-10 was a stronger predictor of maximum 30-day severity and severe AKI than increases in IL-6 or IL-8.ConclusionsThe hyperinflammatory response to COVID-19 is accompanied by a simultaneous anti-inflammatory response, which is associated with poor outcomes and may increase the risk of new positive bacterial cultures. IL-10 and IL-10/lymphocyte count at ED presentation were independent predictors of COVID-19 severity. Moreover, elevated IL-10 was more strongly associated with outcomes than pro-inflammatory IL-6 or IL-8. The anti-inflammatory response in COVID-19 requires further investigation to enable more precise immunomodulatory therapy against SARS-CoV-2.

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