Cardiac Toxicity with Capecitabine, Vinorelbine and Trastuzumab Therapy: Case Report and Review of Fluoropyrimidine-Related Cardiotoxicity

Oncology ◽  
2009 ◽  
Vol 76 (5) ◽  
pp. 322-325 ◽  
Author(s):  
Valérie Le Brun-Ly ◽  
Jean Martin ◽  
Laurence Venat-Bouvet ◽  
Nicole Darodes ◽  
Jean-Luc Labourey ◽  
...  
Keyword(s):  
Case Report ◽  
Cardiac Toxicity ◽  
Trastuzumab Therapy

Imipramine Poisoning

1980 ◽  
Vol 1 (10) ◽  
pp. 317-320
Author(s):  
Quang X. Nghiem ◽  
Randy C. Randel ◽  
Thomas L. Leach
Keyword(s):  
Case Report ◽  
Cardiogenic Shock ◽  
Cardiac Toxicity ◽  
Gastric Lavage ◽  
Anticholinergic Syndrome ◽  
Case Presentation ◽  
Common Cause ◽  
Adults And Children ◽  
Electrocardiographic Changes ◽  
Good Agent

The incidence of imipramine poisoning in adults and children is increasing. Toxic effects include an anticholinergic syndrome in the early phase and direct cardiotoxicity that produces abnormalities in rhythm, conduction, and depression of contractility in later phases. In fatal cases, the cardiotoxicity is the most common cause of death. Electrocardiographic changes are so characteristic of imipramine poisoning that the diagnosis can be made or at least suspected on the basis of electrocardiographic alteration. This is illustrated by the case report. Treatment includes induced emesis and/or gastric lavage to remove unabsorbed drug. Diazepam followed by phenobarbital is used to control seizures. Physostigmine is a good agent for treatment of the anticholinergic syndrome, including supraventricular hyperexcitability. Lidocaine is useful for ventricular hyperexcitability. As shown in the case presentation, epinephrine can be effective in reversing the most advanced manifestation of cardiac toxicity, cardiogenic shock.

scholarly journals Oral Phenytoin Toxicity Causing Sinus Arrest: A Case Report

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Ravi K. Thimmisetty ◽  
Janardhana Rao Gorthi ◽  
Mahmoud Abu Hazeem
Keyword(s):  
Case Report ◽  
Cardiac Toxicity ◽  
Case Reports ◽  
Sinus Node ◽  
Seizure Disorder ◽  
Sinus Arrest ◽  
Rare Presentation ◽  
Phenytoin Toxicity

We present a case of sinus node arrest leading to symptomatic junctional bradycardia from oral phenytoin toxicity, which is a rare presentation. Our patient had no prior cardiac history and was on phenytoin therapy for seizure disorder. Although bradycardia is more commonly associated with intravenous phenytoin and there were few case reports of bradycardia with oral phenytoin reported, the literature is limited. In this case report, we also reviewed the pathophysiology of phenytoin-induced cardiac toxicity.

scholarly journals Histological evidence for the cardiac safety of high-dose pegylated liposomal doxorubicin in a patient with HIV-associated Kaposi sarcoma: a case report and literature review

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ayaka Ishihara ◽  
Shuji Hatakeyama ◽  
Jun Suzuki ◽  
Yusuke Amano ◽  
Teppei Sasahara ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cumulative Dose ◽  
Liposomal Doxorubicin ◽  
Cardiac Toxicity ◽  
Pegylated Liposomal Doxorubicin ◽  
Kaposi Sarcoma ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction

Abstract Background Pegylated liposomal doxorubicin plays an important role in the treatment of patients with severe refractory human immunodeficiency virus (HIV)-associated Kaposi sarcoma (KS). High cumulative doses of conventional doxorubicin exceeding 500 mg/m2 are known to cause cardiac toxicity. However, the safe cumulative dose of pegylated liposomal doxorubicin is unclear. Case presentation A 40-year-old Japanese man with HIV infection presented with pain, edema, and multiple skin nodules on both legs which worsened over several months. He was diagnosed with HIV-associated KS. He received long-term pegylated liposomal doxorubicin combined with antiretroviral therapy for advanced, progressive KS. The cumulative dose of pegylated liposomal doxorubicin reached 980 mg/m2. The patient’s left ventricular ejection fraction remained unchanged from baseline during treatment. After he died as a result of cachexia and wasting, caused by recurrent sepsis and advanced KS, an autopsy specimen of his heart revealed little or no evidence of histological cardiac damage. We also conducted a literature review focusing on histological changes of the myocardium in patients treated with a cumulative dose of pegylated liposomal doxorubicin exceeding 500 mg/m2. Conclusions This case report and literature review suggest that high (> 500 mg/m2) cumulative doses of pegylated liposomal doxorubicin may be used without significant histological/clinical cardiac toxicity in patients with HIV-associated KS.

scholarly journals Calotropis poisoning with severe cardiac toxicity A case report

2020 ◽  
Vol 9 (8) ◽  
pp. 4444
Author(s):  
Ramya Iyadurai ◽  
Karthik Gunasekaran ◽  
Arun Jose ◽  
Kishore Pitchaimuthu
Keyword(s):  
Case Report ◽  
Cardiac Toxicity

scholarly journals Amphotericin B Induced Anaphylactic Reaction and Electrolyte Imbalance: A Case Report

2021 ◽  
pp. 735-739
Author(s):  
Sheik Haja Sherief ◽  
Shilpa Johny Chackupurackal ◽  
S. Sengottuvelu ◽  
Mercy Dora ◽  
V. Manivannan ◽  
...  
Keyword(s):  
Case Report ◽  
Fungal Infection ◽  
Amphotericin B ◽  
Anaphylactic Reaction ◽  
Cardiac Toxicity ◽  
Electrolyte Imbalance ◽  
Allergic Reactions ◽  
Chest Discomfort ◽  
Life Threatening ◽  
Streptomyces Nodosus

Amphotericin B, a polyene antifungal antibiotic derived from a strain of Streptomyces nodosus. It acts by binding to sterols in the cell membrane of susceptible fungi, with a resultant change in the permeability of the membrane. Amphotericin B can cause allergic reactions, electrolyte imbalance and severe side effects, such as chest discomfort accompanied by dyspnea, flushing, agitation, tachypnea, tachycardia, hypoxemia, hypotension, or hypertension, are likely to develop following the injection of Amphotericin B. Anaphylaxis, cardiac toxicity and respiratory failure have also been associated to different formulations of Amphotericin B as life-threatening acute events. This case report is on a 57-year-old male patient who was admitted with a condition of left diabetic foot with non-healing medial supra heel ulcer and fungal infection on the site of wound. The patient was given Amphotericin B in emulsion form due to the high priority of fungal infection and the need for antifungal medicine, which led to anaphylactic reaction and electrolyte imbalance, which were treated immediately and the same preparation was continued with a low infusion rate. When infusion is discontinued, antihistamines can assist to alleviate the symptoms. In this case, it is recommended that the patient's condition and clinical parameters should be closely followed after the medicine has been administered.

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