The Effect of Packed Cell Volume, Hemoglobin Content and Red Cell Count on Whole Blood Viscosity

1970 ◽  
Vol 44 (3) ◽  
pp. 142-154 ◽  
Author(s):  
H. Hershko ◽  
D. Carmeli
Keyword(s):  
Cell Count ◽  
Cell Volume ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Packed Cell Volume ◽  
Red Cell ◽  
Hemoglobin Content ◽  
Whole Blood Viscosity ◽  
Red Cell Count

scholarly journals THE BLOOD PICTURE OF SHEEP FED ON FRESH AND DRIED MARROW-STEM KALE

1973 ◽  
Vol 53 (2) ◽  
pp. 229-236 ◽  
Author(s):  
G. PELLETIER ◽  
L. J. MARTIN
Keyword(s):  
Low Temperature ◽  
Cell Count ◽  
Cell Volume ◽  
Packed Cell Volume ◽  
Red Cell ◽  
Blood Cell Count ◽  
Blood Picture ◽  
Short Period ◽  
Red Blood Cell Count ◽  
Red Cell Count

Sheep were used to compare the anemia effects of fresh marrow-stem kale (Brassica oleracea var. acephala D.C.) with low-temperature dehydrated marrow-stem kale (MSK). There was a drop in hemoglobin (P < 0.01), packed-cell volume (P < 0.05), and red blood cell count (P < 0.05) after the 4th, 5th, and 6th wk, respectively, of feeding fresh MSK. Similar drops in hemoglobin (P < 0.05), packed-cell volume (P < 0.05), and red cell count (P < 0.05) occurred after the 4th wk of feeding dried MSK. Formation of Heinz-Ehrlich bodies peaked at the corresponding lowest values of hemoglobin and packed-cell volume for both fresh and dried MSK. These criteria returned almost to normal in the 2nd and 3rd wk after stopping the feeding of kale and using ground hay as the entire ration instead. It was concluded that high levels of either fresh or dried MSK could not be fed to sheep even for a relatively short period of time.

scholarly journals Effect of High Concentrations of Leukocytes on Whole Blood Viscosity

Blood ◽  
1971 ◽  
Vol 38 (3) ◽  
pp. 299-301 ◽  
Author(s):  
MARTIN H. STEINBERG ◽  
STANLEY E. CHARM
Keyword(s):  
Cell Volume ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Packed Cell Volume ◽  
Leukocyte Count ◽  
Whole Blood Viscosity ◽  
High Concentrations ◽  
Normal Variability

Abstract Whole blood viscosity of patients with leukemic leukocytosis was compared to that of normals with a similar total packed cell volume (TPCV). Leukocytes in suspension were also studied and found to have a greater viscosity than erythrocytes. We found no relation between the magnitude of the leukocyte count and whole blood viscosity. The presence of anemia in the patients with leukemia prevented elevation of their TPCV. This, as well as the normal variability of blood viscosity obscured any increase that could have been produced by the greater viscosity of massed leukocytes.

scholarly journals Anaemia a practical approach for nursing and paramedical specialities

Curationis ◽  
1981 ◽  
Vol 3 (4) ◽  
Author(s):  
L. Wood
Keyword(s):  
Cell Count ◽  
Cell Volume ◽  
Peripheral Blood ◽  
Packed Cell Volume ◽  
Cell Mass ◽  
Underlying Disease ◽  
Red Cell ◽  
Red Cell Mass ◽  
Blood Formation ◽  
Red Cell Count

Anaemia is only a symptom and not, in itself, a diagnosis. Its importance lies in the fact that it signals underlying disease which is often correctable. By definiton anaemia is a reduction in red cell mass and this is reflected in reduced haemoglobin, packed cell volume, or red cell count in the peripheral blood. To understand the mechanisms of its development normal blood formation must be briefly reviewed.

Viscosity and Red Cell Deformity in Arterial Disease

1979 ◽  
Author(s):  
G Cella ◽  
H de Haas ◽  
M Rampling ◽  
V Kakkar
Keyword(s):  
Vascular Disease ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Arterial Disease ◽  
Plasma Viscosity ◽  
Control Group ◽  
Fibrinogen Concentration ◽  
Red Cell ◽  
Whole Blood Viscosity ◽  
Significant Difference

Haemorrheological factors have been shown to be affected in many kings of vascular disease. The present study was undertaken to correlate these factors in normal subjects and patients suffering from peripheral arterial disease. Twenty-two patients were investigated; they had moderate or severe intermittent claudication, extent of disease being confirmed by aorto-arteriography and ankle-systolic pressure studies. Twenty-five controls with no symptoms or signs of arterial disease were selected with comparable age and sex distribution. Whole blood viscosity was measured at shear rates of 230 secs-1 and 23 secs-lat 37°c using a Wells Brookfield cone plate microvisco meter. Plasma viscosity was also measured in an identical manner. Erythrocyte flexibility was measured by centrifuge technique and fibrinogen concentration as well as haematocrit by standard techniques. The fibrinogen concentration appeared to be the only significant parameter; the mean concentration in patients with peripheral vascular disease of 463 ± 73mg/l00ml in the control group ( < 0.05). Although whole blood viscosity was high in patients, when corrected to a common haematocrit, there was no significant difference between patients and controls. The same megative correlation was found for plasma viscosity. The red cell flexibility was found to be increased in patients as compared to the control group, but this effect appeared to be simply proportional to the fibrinogen concentration.

Genetic and Environmental Effects on Blood Cells

1993 ◽  
Vol 42 (3-4) ◽  
pp. 245-252 ◽  
Author(s):  
G.M.D. Dal Colletto ◽  
D.W. Fulker ◽  
O.C. de O. Barretto ◽  
M. Kolya
Keyword(s):  
Cell Count ◽  
Cell Volume ◽  
White Cell Count ◽  
Haemoglobin Concentration ◽  
Red Cell ◽  
Heritable Variation ◽  
Mean Cell Volume ◽  
Twin Analysis ◽  
Sources Of Variation ◽  
Red Cell Count

AbstractIn a sample of 105 concordant sex MZ and DZ twin pairs, the following characteristics were measured: red cell count, haemoglobin concentration, package cell volume, mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration, reticulocytes, platelets, white cell count and the six types of leucocytes, lymphocytes, monocytes, band and segmented neutrophils, eosinophils and basophils. The statistical model employed in the univariate twin analysis allows for three sources of variation: genetic (h2), shared environmental (c2) and specific environmental influences (e2). A genetic component was significant for red cell count, haemoglobin and mean cell haemoglobin (0.64, 0.60 and 0.46 respectively), with heritable variation suggested for package cell volume, mean cell volume, mean cell haemoglobin, lymphocytes and monocytes. Shared environmental variation was only present for neutrophils.

Viscosity and Red Cell Deformity in Arterial Disease

1979 ◽  
Author(s):  
G. Cella ◽  
H.A. de Haas ◽  
M. Rampling ◽  
V.V. Kakkar
Keyword(s):  
Vascular Disease ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Arterial Disease ◽  
Plasma Viscosity ◽  
Control Group ◽  
Fibrinogen Concentration ◽  
Red Cell ◽  
Whole Blood Viscosity ◽  
Significant Difference

Haemorrheological factors have been shown to be affected in many kings of vascular disease. The present study was undertaken to correlate these factors in normal subjects and patients suffering from peripheral arterial disease. Twenty-two patients were investigated; they had moderate or severe intermittent claudication, extent of disease being confirmed by aorto-arteriography and ankle-systolic pressure studies. Twenty-five controls with no symptoms or signs of arterial disease were selected withcomparable age and sex distribution. Whole blood viscosity was measured at shear rates of 230 secs-1 and 23 sees-1 at 37°C using a Weils Brookfield cone plate microvisco meter. Plasma viscosity was also measured in an identical manner. Erythrocyte flexibility was measured by centrifuge technique and fibrinogen concentration as well as haematocrit by standard techniques. The fibrinogen concentration appeared to be the only significant parameter; the mean concentration in patients with peripheral vascular disease of 463 ± 73mg/100ml in the control group ( 〈 0.05). Although whole blood viscosity was high in patients, when corrected t. a common haematocrit, there was no significant difference between patients and controls The same megative correlation was found for plasma viscosity. The red cell flexibility was found to be increased in patients as compared to the control group, but this effect appeared to be simply proportional to the fibrinogen concentration.

Abnormal Red Cell Deformability and Aggregation in Sickle Cell Trait

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 1001-1001
Author(s):  
Jon Detterich ◽  
Adam M Bush ◽  
Roberta Miyeko Kato ◽  
Rose Wenby ◽  
Thomas D. Coates ◽  
...  
Keyword(s):  
Blood Flow ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Red Cell ◽  
Cell Deformability ◽  
Autologous Plasma ◽  
Red Cell Deformability ◽  
Whole Blood Viscosity ◽  
Rbc Aggregation ◽  
Rbc Deformability

Abstract Abstract 1001 Introduction: SCT occurs in 8% of African Americans and is not commonly associated with clinical disease. Nonetheless, the United States Armed Forces has reported that SCT conveys a 30-fold risk of sudden cardiac arrest and a 200-fold risk from exertional rhabdomyolysis. In fact, rhabdomyolysis in athletes with SCT has been the principal cause of death in NCAA football players in the last decade, leading to recently mandated SCT testing in all Division-1 players. In SCT, RBC sickle only under extreme conditions and with slow kinetics. Therefore, rhabdomyolysis most likely occurs in SCT when a “perfect storm” of factors converges to critically imbalance oxygen supply and demand in muscles. We hypothesize that in SCT subjects, abnormal RBC rheology, particularly aggregation and deformability, play an important role in abnormal muscle blood flow supply and distribution to exercising muscle. To test this hypothesis, we examined whole blood viscosity, RBC aggregation, and RBC deformability in 11 SCT and 10 control subjects prior to and following maximum handgrip exercise. Methods: Maximum voluntary contraction (MVC) was assessed by handgrip dynamometer in the dominant arm. Baseline blood was collected for CBC, whole blood viscosity, RBC aggregation, and RBC deformability. Patients then maintained 60% MVC exercise until exhaustion. Following 8 minutes of recovery, a venous blood gas and blood for repeat viscosity assessments was collected from the antecubital fossa of the exercising limb. Whole blood viscosity over a shear rate range of 1–1, 000 1/s was determined by an automated tube viscometer, RBC deformability from 0.5–50 Pa via laser ektacytometry (LORCA) and RBC aggregation in both autologous plasma and 3% dextran 70 kDa using an automated cone-place aggregometer (Myrenne). Aggregation measurements included extent at stasis (M), strength of aggregation (GT min) and kinetics (T ½). Results: Baseline CBC and aggregation values are summarized in Table 1. Both static RBC aggregation in plasma and RBC aggregation in dextran (aggregability) were significantly increased in SCT (Table 1). The rate of aggregation formation trended higher in SCT but the strength of aggregation was not different between the two groups. In SCT subjects, red cell deformability was impaired at low shear stress but greater than controls at higher shear stress (Figure 1). Red cell deformability was completely independent of oxygenation status states in both SCT and control subjects. Whole blood viscosity did not different between the two groups whether oxygenated or deoxygenated and prior to or following handgrip exercise. Discussion: Three important hemorheological differences were observed for SCT subjects versus controls: a) RBC deformability was below control at low stress levels yet greater than control at higher stress; b) The extent of RBC aggregation in autologous plasma was about 40% greater; c) The extent of RBC aggregation for washed RBC re-suspended in an aggregating medium (i.e., 3% dextran 70 kDa) was about 30% higher. RBC deformability is a major determinant of in vivo blood flow dynamics, especially in the microcirculation; decreased deformability adversely affects tissue perfusion. RBC aggregation is also an important determinant since it affects both resistance to blood flow and RBC distribution in a vascular bed (e.g., plasma skimming). The finding of greater aggregability (i.e., higher aggregation in the defined dextran medium) indicates that RBC in SCT have an altered membrane surface in which the penetration of this polymer into the glycocalyx is abnormal. The combined effects of these three rheological parameters is likely to impair in vivo blood flow in SCT, perhaps to a degree resulting in pathophysiological changes of the cardiovascular system. Disclosures: Coates: Novartis: Speakers Bureau; Apopharma: Consultancy. Wood:Ferrokin Biosciences: Consultancy; Shire: Consultancy; Apotex: Consultancy, Honoraria; Novartis: Honoraria, Research Funding.

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