Cryptorchidism as Part of the Testicular Dysgenesis Syndrome: The Environmental Connection

2009 ◽  
pp. 167-173 ◽  
Author(s):  
K.M. Main ◽  
N.E. Skakkebæk ◽  
J. Toppari
Keyword(s):  
Testicular Dysgenesis Syndrome ◽  
Testicular Dysgenesis

Testicular dysgenesis syndrome: foetal origin of adult reproductive problems

2009 ◽  
Vol 71 (4) ◽  
pp. 459-465 ◽  
Author(s):  
Christine Wohlfahrt-Veje ◽  
Katharina M. Main ◽  
Niels Erik Skakkebaek
Keyword(s):  
Testicular Dysgenesis Syndrome ◽  
Testicular Dysgenesis

scholarly journals Identification of a Novel Androgen Receptor Mutation in a Family With Multiple Components Compatible With the Testicular Dysgenesis Syndrome

2013 ◽  
Vol 98 (6) ◽  
pp. 2223-2229 ◽  
Author(s):  
Grete Lottrup ◽  
Anne Jørgensen ◽  
John E. Nielsen ◽  
Niels Jørgensen ◽  
Morten Duno ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Testicular Dysgenesis Syndrome ◽  
Multiple Components ◽  
Testicular Dysgenesis

Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: Evidence from 20 adult patients with signs of maldevelopment of the testis

Apmis ◽  
2003 ◽  
Vol 111 (1) ◽  
pp. 1-11 ◽  
Author(s):  
NIELS E. SKAKKEBAEK ◽  
METTE HOLM ◽  
CHRISTINA HOEI-HANSEN ◽  
NIELS JORGENSEN ◽  
EWA RAJPERT-DE MEYTS
Keyword(s):  
Adult Patients ◽  
Testicular Dysgenesis Syndrome ◽  
Testicular Dysgenesis

Testicular dysgenesis syndrome and the development and occurrence of male reproductive disorders

2005 ◽  
Vol 207 (2) ◽  
pp. 501-505 ◽  
Author(s):  
H VIRTANEN ◽  
E RAJPERTDEMEYTS ◽  
K MAIN ◽  
N SKAKKEBAEK ◽  
J TOPPARI
Keyword(s):  
Reproductive Disorders ◽  
Testicular Dysgenesis Syndrome ◽  
Testicular Dysgenesis

scholarly journals Phthalate-induced pathology in the foetal testis involves more than decreased testosterone production

Reproduction ◽  
2014 ◽  
Vol 147 (4) ◽  
pp. 435-442 ◽  
Author(s):  
D N Rao Veeramachaneni ◽  
Gary R Klinefelter
Keyword(s):  
Reproductive Tract ◽  
Comprehensive Evaluation ◽  
Male Rats ◽  
Testicular Dysgenesis Syndrome ◽  
Pathway Network ◽  
New Findings ◽  
Testicular Dysgenesis ◽  
And Migration ◽  
And Function ◽  
Rats And Mice

Foetal exposure to phthalates is known to adversely impact male reproductive development and function. Developmental anomalies of reproductive tract have been attributed to impaired testosterone synthesis. However, species differences in the ability to produce testosterone have been noted; e.g., following foetal exposure, abnormal clustering of Leydig cells or decreased production of testosterone that is manifested in rats does not occur in mice or humans. Nonetheless, other facets of testicular dysgenesis occur in both rats and mice as well as in some other species tested. We recently published a comprehensive evaluation of the foetal rat testis proteome, following in utero exposure to diethylhexyl phthalate (DEHP), which revealed changes in individual proteins that are known to be factors in cellular differentiation and migration or related to the capacity of the foetal Leydig cell to produce testosterone and fit a pathway network in which each is regulated directly or indirectly by oestradiol. Plasma oestradiol indeed was found to be elevated approximately twofold in 19-day-old DEHP-exposed foetal male rats. In this brief review, we discuss our new findings vis-à-vis ‘oestrogen hypothesis’ as a cause for testicular dysgenesis syndrome.

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