scholarly journals Cold Urticaria: An Unusual Manifestation of Histiocytic Lymphoma

1982 ◽  
Vol 68 (4) ◽  
pp. 343-344 ◽  
Author(s):  
Aaron Polliack ◽  
Eldad Ben-Chetrit ◽  
Zvi Stern
Keyword(s):  
Cold Urticaria ◽  
Unusual Manifestation ◽  
Histiocytic Lymphoma

Familial cold urticaria. Clinical findings

1974 ◽  
Vol 110 (3) ◽  
pp. 382-388 ◽  
Author(s):  
H. M. Doeglas
Keyword(s):  
Clinical Findings ◽  
Cold Urticaria

A non-resolving splenic ‘abscess’ in an elderly male – An unusual manifestation of splenic lymphoma

2020 ◽  
pp. 004947552098130
Author(s):  
Raj K Nagarajan ◽  
Balasubramanian Gopal ◽  
Muhamed Tajudeen ◽  
Sarath C Sistla ◽  
K Balamourougan
Keyword(s):  
Risk Factors ◽  
Splenic Abscess ◽  
Low Grade ◽  
Surgical Drainage ◽  
Elderly Male ◽  
Unusual Manifestation ◽  
Splenic Lymphoma ◽  
Haematogenous Spread ◽  
Uncommon Condition ◽  
Abscess Wall

Splenic abscess is a relatively uncommon condition, posing a diagnostic and therapeutic challenge for the treating physician. It occurs due to haematogenous spread from endocarditis or other septic foci, especially in immune-compromised individuals and diabetics. We describe an elderly male who presented with splenomegaly and low-grade fever with no predisposing factors. Examination revealed a tender splenomegaly. Ultrasonography (US) showed a hypoechoic area within the spleen from which guided aspiration of pus grew Staphylococcus aureus and Klebsiella pneumoniae. Percutaneous drainage and culture-based antibiotics failed to resolve the abscess, obligating surgical drainage. Intraoperative biopsy from the abscess wall was reported as splenic marginal lymphoma. This unusual presentation of lymphoma needs to be considered in splenic abscess without known risk factors.

scholarly journals 8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1

2021 ◽  
Vol 22 (11) ◽  
pp. 5516
Author(s):  
Qiting Zhang ◽  
Ziyan Wang ◽  
Xinyuan Chen ◽  
Haoxiang Qiu ◽  
Yifan Gu ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Dna Methyltransferase ◽  
Hdac Inhibitors ◽  
Mitochondrial Pathway ◽  
Epigenetic Therapy ◽  
Protein Interaction Data ◽  
Dependent Manner ◽  
Histone Deacetylase 1 ◽  
Histiocytic Lymphoma ◽  
Dose Dependent

Epigenetic therapy using histone deacetylase (HDAC) inhibitors has become an attractive project in new drug development. However, DNA methylation and histone acetylation are important epigenetic ways to regulate the occurrence and development of leukemia. Given previous studies, N-(2-aminophenyl)benzamide acridine (8a), as a histone deacetylase 1 (HDAC1) inhibitor, induces apoptosis and shows significant anti-proliferative activity against histiocytic lymphoma U937 cells. HDAC1 plays a role in the nucleus, which we confirmed by finding that 8a entered the nucleus. Subsequently, we verified that 8a mainly passes through the endogenous (mitochondrial) pathway to induce cell apoptosis. From the protein interaction data, we found that 8a also affected the expression of DNA methyltransferase 1 (DNMT1). Therefore, an experiment was performed to assess the binding of 8a to DNMT1 at the molecular and cellular levels. We found that the binding strength of 8a to DNMT1 enhanced in a dose-dependent manner. Additionally, 8a inhibits the expression of DNMT1 mRNA and its protein. These findings suggested that the anti-proliferative and pro-apoptotic activities of 8a against leukemia cells were achieved by targeting HDAC1 and DNMT1.

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