Functional Changes in Marrow Stromal Cells in Aplastic Anaemia

1985 ◽  
Vol 74 (2) ◽  
pp. 65-69 ◽  
Author(s):  
Tomomitsu Hotta ◽  
Taiji Kato ◽  
Hideaki Maeda ◽  
Hisami Yamao ◽  
Hideo Yamada ◽  
...  
Keyword(s):  
Aplastic Anaemia ◽  
Stromal Cells ◽  
Marrow Stromal Cells ◽  
Functional Changes

scholarly journals Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells

2020 ◽  
Vol 21 (1) ◽  
pp. 349 ◽  
Author(s):  
Abdul Qadir ◽  
Shujing Liang ◽  
Zixiang Wu ◽  
Zhihao Chen ◽  
Lifang Hu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Molecular Mechanisms ◽  
Marrow Stromal Cells ◽  
World Population ◽  
Men And Women ◽  
Senile Osteoporosis ◽  
Functional Changes ◽  
The World

Senile osteoporosis has become a worldwide bone disease with the aging of the world population. It increases the risk of bone fracture and seriously affects human health. Unlike postmenopausal osteoporosis which is linked to menopause in women, senile osteoporosis is due to aging, hence, affecting both men and women. It is commonly found in people with more than their 70s. Evidence has shown that with age increase, bone marrow stromal cells (BMSCs) differentiate into more adipocytes rather than osteoblasts and undergo senescence, which leads to decreased bone formation and contributes to senile osteoporosis. Therefore, it is necessary to uncover the molecular mechanisms underlying the functional changes of BMSCs. It will benefit not only for understanding the senile osteoporosis development, but also for finding new therapies to treat senile osteoporosis. Here, we review the recent advances of the functional alterations of BMSCs and the related mechanisms during senile osteoporosis development. Moreover, the treatment of senile osteoporosis by aiming at BMSCs is introduced.

Glucocorticoid exposure reduces expression of sclerostin in bone marrow stromal cells

2013 ◽  
Author(s):  
Sylvia Thiele ◽  
Alexander Rauch ◽  
Jan P Tuckermann ◽  
Lorenz C Hofbauer ◽  
Martina Rauner
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells
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