scholarly journals No Genetic Association between Polymorphisms of Heme Oxygenase 1 and 2 and Alzheimer’s Disease in a Japanese Population

2009 ◽  
Vol 27 (3) ◽  
pp. 273-277 ◽  
Author(s):  
Nobuto Shibata ◽  
Tohru Ohnuma ◽  
Hajime Baba ◽  
Heii Arai
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Association ◽  
Heme Oxygenase ◽  
Japanese Population ◽  
Heme Oxygenase 1

scholarly journals Genetic association between clusterin polymorphisms and Alzheimer's disease in a Japanese population

2011 ◽  
Vol 11 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Miwa KOMATSU ◽  
Nobuto SHIBATA ◽  
Bolati KUERBAN ◽  
Tohru OHNUMA ◽  
Hajime BABA ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Association ◽  
Japanese Population

Induction of Heme Oxygenase-1 mRNA and Protein in Neocortex and Cerebral Vessels in Alzheimer's Disease

2002 ◽  
Vol 65 (3) ◽  
pp. 1399-1402 ◽  
Author(s):  
Daniel R. D. Premkumar ◽  
Mark A. Smith ◽  
Peggy L. Richey ◽  
Robert B. Petersen ◽  
Rudy Castellani ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Heme Oxygenase ◽  
Cerebral Vessels ◽  
Heme Oxygenase 1

Genetic Association between Ghrelin Polymorphisms and Alzheimer’s Disease in a Japanese Population

2011 ◽  
Vol 32 (3) ◽  
pp. 178-181 ◽  
Author(s):  
Nobuto Shibata ◽  
Tohru Ohnuma ◽  
Bolati Kuerban ◽  
Miwa Komatsu ◽  
Heii Arai
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Association ◽  
Japanese Population

Regulation of Heme Oxygenase Expression by Cyclopentenone Prostaglandins

2003 ◽  
Vol 228 (5) ◽  
pp. 499-505 ◽  
Author(s):  
Hean Zhuang ◽  
Sokhon Pin ◽  
Xiaoling Li ◽  
Sylvain Doré
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Heme Oxygenase ◽  
Significant Role ◽  
Neuronal Cell ◽  
Heme Oxygenase 1 ◽  
Neuronal Cultures ◽  
Dependent Manner ◽  
Stress Injury ◽  
Free Radical Damage

Prostaglandins (PGs) originate from the degradation of membranar arachidonic acid by cyclooxygenases (COX-1 and COX-2). The prostaglandin actions in the nervous system are multiple and have been suggested to play a significant role in neurodegenerative disorders. Some PGs have been reported to be toxic and, interestingly, the cyclopentenone PGs have been reported to be cytoprotective at low concentration and could play a significant role in neuronal plasticity. They have been shown to be protective against oxidative stress injury; however, the cellular mechanisms of protection afforded by these PGs are still unclear. It is postulated that the cascade leading to neuronal cell death in acute and chronic neurodegenerative conditions, such as cerebral ischemia and Alzheimer’s disease, would be mediated by free radical damage. We tested the hypothesis that the neuroprotective action of cyclopentanone could be caused partially by an induction of heme oxygenase 1 (HO-1). We and others have previously reported that modulation of HO total activity may well have direct physiological implications in stroke and in Alzheimer’s disease. HO acts as an antioxidant enzyme by degrading heme into iron, carbon monoxide, and biliverdin that is rapidly converted into bilirubin. Using mouse primary neuronal cultures, we demonstrated that PGs of the J series induce HO-1 in a dose-dependent manner (0, 0.5, 5, 10, 20, and 50 μg/ml) and that PGJ2 and dPGJ2 were more potent than PGA2, dPGA2, PGD2, and PGE2. No significant effects were observed for HO-2 and actin expression. In regard to HO-3 expression found in rat, with its protein deducted sequence highly homologous to HO-2, no detection was observed in HO-2−/− mice, suggesting that HO-3 protein would not be present in mouse brain. We are proposing that several of the protective effects of PGJ2 could be mediated through beneficial actions of heme degradation and its metabolites. The design of new mimetics based on the cyclopentenone structure could be very useful as neuroprotective agents and be tested in animal models of stroke and Alzheimer’s disease.

Genetic association between APOA1 and APOD polymorphisms and Alzheimer’s disease in a Japanese population

2013 ◽  
Vol 120 (11) ◽  
pp. 1599-1603 ◽  
Author(s):  
Nobuto Shibata ◽  
Tomoyuki Nagata ◽  
Shunichiro Shinagawa ◽  
Tohru Ohnuma ◽  
Hiromi Shimazaki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Association ◽  
Japanese Population

Genetic Association between PLTP Gene Polymorphisms and Alzheimer’s Disease in a Japanese Population

2010 ◽  
Vol 30 (1) ◽  
pp. 78-82 ◽  
Author(s):  
Bolati Kuerban ◽  
Nobuto Shibata ◽  
Miwa Komatsu ◽  
Tohru Ohnuma ◽  
Heii Arai
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Association ◽  
Japanese Population ◽  
Gene Polymorphisms

scholarly journals Relationship between Brain Tissue Changes and Blood Biomarkers of Cyclophilin A, Heme Oxygenase-1, and Inositol-Requiring Enzyme 1 in Patients with Alzheimer’s Disease

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 740
Author(s):  
Hyon-Il Choi ◽  
Kiyoon Kim ◽  
Jiyoon Lee ◽  
Yunjung Chang ◽  
Hak Young Rhee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Globus Pallidus ◽  
Serum Protein ◽  
Heme Oxygenase ◽  
Brain Magnetic Resonance Imaging ◽  
Cyclophilin A ◽  
Blood Levels ◽  
Heme Oxygenase 1 ◽  
Protein Levels

Cyclophilin A (CypA), heme oxygenase-1 (HO-1), and inositol-requiring enzyme 1 (IRE1) are believed to be associated with Alzheimer’s disease (AD). In this study, we investigated the association between gray matter volume (GMV) changes and blood levels of CypA, HO-1, and IRE1 in cognitively normal (CN) subjects and those with amnestic mild cognitive impairment (aMCI) and AD. Forty-five elderly CN, 34 aMCI, and 39 AD subjects were enrolled in this study. The results of voxel-based multiple regression analysis showed that blood levels of CypA, HO-1, and IRE1 were correlated with GMV on brain magnetic resonance imaging (MRI) in the entire population (p = 0.0005). The three serum protein levels were correlated with GMV of signature AD regions in the population as a whole. CypA values increased with increasing GMV in the occipital gyrus (r = 0.387, p < 0.0001) and posterior cingulate (r = 0.196, p = 0.034). HO-1 values increased with increasing GMV at the uncus (r = 0.307, p = 0.0008), lateral globus pallidus and putamen (r = 0.287, p = 0.002), and hippocampus (r = 0.197, p = 0.034). IRE1 values decreased with increasing GMV at the uncus (r = −0.239, p = 0.010) and lateral globus pallidus and putamen (r = −0.335, p = 0.0002). Associations between the three serum protein levels and regional GMV indicate that the blood levels of these biomarkers may reflect the pathological mechanism of AD in the brain.

Genetic Association Between KIBRA Polymorphism and Alzheimer’s Disease with in a Japanese Population

2015 ◽  
Vol 17 (2) ◽  
pp. 170-177 ◽  
Author(s):  
Eri Kawai ◽  
Nobuto Shibata ◽  
Tomoyuki Nagata ◽  
Shunichiro Shinagawa ◽  
Kenji Tgai ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Association ◽  
Japanese Population
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