Serial Quantitative Liver Function Tests in Patients with Primary Biliary Cirrhosis: A Prospective Long-Term Study

Digestion ◽  
1997 ◽  
Vol 58 (4) ◽  
pp. 396-401 ◽  
Author(s):  
J. v. Schönfeld ◽  
N. Breuer ◽  
R.B. Zotz ◽  
M. Beste ◽  
H. Goebell
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Liver Function ◽  
Liver Function Tests ◽  
Biliary Cirrhosis ◽  
Term Study ◽  
Long Term Study ◽  
Function Tests

scholarly journals Primary biliary cirrhosis and hepatic sarcoidosis: A case report

2014 ◽  
Vol 71 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Tamara Alempijevic ◽  
Aleksandra Sokic-Milutinovic ◽  
Ljubisa Toncev ◽  
Aleksandra Pavlovic-Markovic ◽  
Srdjan Djuranovic ◽  
...  
Keyword(s):  
Case Report ◽  
Primary Biliary Cirrhosis ◽  
Liver Function ◽  
Elevated Serum ◽  
Liver Function Tests ◽  
Unknown Etiology ◽  
Biliary Cirrhosis ◽  
Laboratory Findings ◽  
Function Tests ◽  
Elevated Liver Function Tests

Introduction. Primary biliary cirrhosis (PBC) is an immunemediated chronic progressive inflammatory liver disease leading to destruction of small interlobular bile ducts. Sarcoidosis is a chronic disorder of unknown etiology characterized by non-caseous granulomas. Case report. We reported a 69-year-old female patient with abdominal pain, malaise, vertigo, headaches, hands tremor and partial loss of hearing. Initial laboratory findings revealed elevated liver function tests and cholesterol with positive antimytochondrial and antinuclear antibodies. Liver biopsy revealed granuloma typical for PBC and granulomatous lesions typical for sarcoidosis. Elevated serum angiotensin-converting enzyme and granulomatous lesion on the brain magnetic resonance imaging (MRI) were detected and the patient was diagnosed with overlap of PBC and liver sarcoidosis and neurosarcoidosis. The patient was treated with ursodeoxicholic acid (UDCA) and prednisolone. Six months later the patient was symptom-free with laboratory findings within normal range. Conclusion. In PBC patients it is important to consider coexisting granulomatous liver diseases if elevated liver function tests persist despite UDCA therapy.

Comparison of quantitative liver function tests and common prognostic scores in patients with primary biliary cirrhosis

2002 ◽  
Vol 36 ◽  
pp. 54
Author(s):  
Christoph Herold ◽  
Christine Deynet ◽  
Marion Ganslmayer ◽  
Eckhart G. Hahn ◽  
Detlef Schuppan
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Liver Function ◽  
Liver Function Tests ◽  
Prognostic Scores ◽  
Biliary Cirrhosis ◽  
Function Tests

Positive Antimitochondrial Antibody, Normal Liver Function Tests: Is this Primary Biliary Cirrhosis?

1985 ◽  
Vol 69 (s12) ◽  
pp. 64P-64P
Author(s):  
H. Mitchison ◽  
G. Bird ◽  
M. Bennett ◽  
A.J. Watson ◽  
M.F. Bassendine ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Liver Function ◽  
Normal Liver ◽  
Liver Function Tests ◽  
Biliary Cirrhosis ◽  
Normal Liver Function ◽  
Antimitochondrial Antibody ◽  
Function Tests

scholarly journals Abnormal Liver Function Tests and Long-Term Outcomes in Patients Discharged after Acute Heart Failure

2021 ◽  
Vol 10 (8) ◽  
pp. 1730
Author(s):  
Hiroshi Miyama ◽  
Yasuyuki Shiraishi ◽  
Shun Kohsaka ◽  
Ayumi Goda ◽  
Yosuke Nishihata ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Function ◽  
Liver Function Tests ◽  
Abnormal Liver Function ◽  
Adverse Outcomes ◽  
Long Term Outcomes ◽  
Function Tests ◽  
Parameter Values

Abnormal liver function tests (LFTs) are known to be associated with impaired clinical outcomes in heart failure (HF) patients. However, this implication varies with each single LFT panel. We aim to evaluate the long-term outcomes of acute HF (AHF) patients by assessing multiple LFT panels in combination. From a prospective multicenter registry in Japan, 1158 AHF patients who were successfully discharged were analyzed (mean age, 73.9 ± 13.5 years; men, 58%). LFTs (i.e., total bilirubin, aspartate aminotransferase or alanine aminotransferase, and alkaline phosphatase) at discharge were assessed; borderline and abnormal LFTs were defined as 1 and ≥2 parameter values above the normal range, respectively. The primary endpoint was composite of all-cause death or HF readmission. At the time of discharge, 28.7% and 8.6% of patients showed borderline and abnormal LFTs, respectively. There were 196 (16.9%) deaths and 298 (25.7%) HF readmissions during a median 12.4-month follow-up period. The abnormal LFTs group had a significantly higher risk of experiencing the composite outcome (adjusted hazard ratio: 1.51, 95% confidence interval: 1.08–2.12, p = 0.017), whereas the borderline LFTs group was not associated with higher risk of adverse events when referenced to the normal LFTs group. Among AHF patients, the combined elevation of ≥2 LFT panels at discharge was associated with long-term adverse outcomes.

Long-term effect of nadolol on quantitative liver function tests in patients with cirrhosis

1988 ◽  
Vol 34 (5) ◽  
pp. 501-504 ◽  
Author(s):  
C. Merkel ◽  
A. Gatta ◽  
D. Sacerdoti ◽  
M. Bolognesi ◽  
M. Rondana ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Term Effect ◽  
Function Tests ◽  
Long Term Effect

THE EFFECT OF LONG-TERM NEUROLEPTIC TREATMENT ON LIVER FUNCTION TESTS

1992 ◽  
Vol 15 ◽  
pp. 347B
Author(s):  
Nihat Alpay ◽  
Celal Ulaşolu ◽  
Yücel Aargün ◽  
Murat Huten
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Neuroleptic Treatment ◽  
Function Tests

scholarly journals The German ACROSTUDY: past and present

2009 ◽  
Vol 161 (suppl_1) ◽  
pp. S3-S10 ◽  
Author(s):  
M Buchfelder ◽  
S Schlaffer ◽  
M Droste ◽  
K Mann ◽  
B Saller ◽  
...  
Keyword(s):  
Liver Function ◽  
Adverse Events ◽  
Observational Study ◽  
Tumor Size ◽  
Safety Data ◽  
Rare Event ◽  
Liver Function Tests ◽  
Long Term Results ◽  
Function Tests

Pivotal studies have demonstrated that pharmacotherapy with pegvisomant (Somavert) is a highly effective treatment for acromegaly. Since clinical experience with the drug was very limited, the Pegvisomant Observational Study was launched in Germany immediately with the drug becoming commercially available to patients early in 2004. Its purpose was to record safety and efficacy data on as many patients as possible. As of 12th August 2008 a total of 371 patients (185 males, 186 females) had been included in the study. They were on pegvisomant therapy for an average of 118 weeks. Median and mean doses of pegvisomant were 15 and 16.4 mg/day respectively. Treatment efficacy was monitored by IGF1 levels and the patients symptoms were evaluated by completion of a questionnaire (patient-assessed acromegaly symptom questionnaire). Safety data included liver function tests, fasting glucose, HbA1c measurements, and tumor size monitoring by repeated magnetic resonance imaging. Normalization of IGF1 ranged from 55.7% of the 273 patients assessed after 6 months to 71.3% of 202 patients assessed after 24 months of treatment. It was 70.7% after 36 months (133 patients), 64.8% at 48 months (71 patients), and 58.4% after 60 months (24 patients). In 39 patients (10.9%) treatment was discontinued due to serious adverse events or adverse events with 25 (6.7%) of these patients having a potential causal relationship with the pegvisomant treatment. Liver function tests became abnormal in 20 patients and another three patients were recorded to have hepatobiliary disorders. Tumor size increase was reported in 20 patients, but only confirmed in nine patients by careful revision of all available images. Local injection site reactions were observed in 12 patients. In conclusion, in this large group of pegvisomant-treated patients, long-term data for up to 5 years of treatment are now available. In 71.3% of patients with previously not sufficiently treatable acromegaly, IGF1 levels were normalized by pegvisomant therapy. Elevated transaminases usually normalized after discontinuation but in half of the affected patients also despite continuation of treatment without dose alteration. Tumor progression was a rare event. It did not exceed the expected rate in patients with acromegaly not treated with pegvisomant. As from this presently largest database of acromegalic patients treated with pegvisomant, long-term results are encouraging. The German data are now merged into the global ACROSTUDY and will constitute a major portion of the international ACROSTUDY project as a continuing global web-based observational study.

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