The Ultimate Biochemical Diagnosis of Gastro-Enteropancreatic Tumours

Kjell Öberg

doi:10.1159/000201394

Abstract #1010: Reliability of the Androgen Deficiency in Aging Male Questionnaire as a Surrogate to Biochemical Diagnosis of Male Hypogonadism in Black Sub-Saharan Africans with Diabetes Mellitus

Endocrine Practice ◽

10.1016/s1530-891x(20)44707-x ◽

2016 ◽

Vol 22 ◽

pp. 232-233

Author(s):

Theophilus Ugwu ◽

Rosemary Ikem ◽

Babatope Kolawole

Keyword(s):

Diabetes Mellitus ◽

Male Hypogonadism ◽

Androgen Deficiency ◽

Aging Male ◽

Biochemical Diagnosis ◽

Sub Saharan

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Seasonal variation of plasma free normetanephrine concentrations: implications for biochemical diagnosis of pheochromocytoma

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0034-1371997 ◽

2014 ◽

Vol 122 (03) ◽

Author(s):

C Pamporaki ◽

M Bursztyn ◽

M Reimann ◽

T Ziemssen ◽

SR Bornstein ◽

...

Keyword(s):

Seasonal Variation ◽

Biochemical Diagnosis

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Prenatal biochemical diagnosis of two forms of congenital diarrheal disorders (congenital chloride diarrhea and congenital sodium diarrhea): A series of 12 cases

Prenatal Diagnosis ◽

10.1002/pd.5878 ◽

2021 ◽

Author(s):

Laure Macraigne ◽

Bichr Allaf ◽

Christophe Buffat ◽

Emmanuel Spaggiari ◽

Georges Dimitrov ◽

...

Keyword(s):

Congenital Chloride Diarrhea ◽

Biochemical Diagnosis

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The Biochemical Diagnosis of Acromegaly

Journal of Clinical Medicine ◽

10.3390/jcm10051147 ◽

2021 ◽

Vol 10 (5) ◽

pp. 1147

Author(s):

Amit Akirov ◽

Hiba Masri-Iraqi ◽

Idit Dotan ◽

Ilan Shimon

Keyword(s):

English Language ◽

Diagnostic Delay ◽

Tolerance Test ◽

Oral Glucose ◽

Published Data ◽

Biochemical Diagnosis ◽

Key Factor ◽

Assay Methods ◽

Serum Gh

Background: The diagnosis of acromegaly still poses a clinical challenge, and prolonged diagnostic delay is common. The most important assays for the biochemical diagnosis and management of acromegaly are growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Objective: Discuss the role of IGF-1, basal serum GH, and nadir GH after oral glucose tolerance test (OGTT) for the diagnosis, management, and treatment of patients with acromegaly. Methods: We performed a narrative review of the published data on the biochemical diagnosis and monitoring of acromegaly. An English-language search for relevant studies was conducted on PubMed from inception to 1 January 2021. The reference lists of relevant studies were also reviewed. Results: Serum IGF-1 levels, basal GH values, and nadir GH after OGTT play a major role in the diagnosis, management, and treatment of patients with acromegaly. Measurement of IGF-1 levels is the key factor in the diagnosis and monitoring of acromegaly, but basal and nadir GH following OGTT are also important. However, several factors may significantly influence the concentrations of these hormones, including assay methods, physiologic and pathologic factors. In some cases, discordant GH and IGF-1 levels may be challenging and usually requires additional data and monitoring. Conclusion: New GH and IGF-1 standards are much more precise and provide more accurate tools to diagnose and monitor patients with acromegaly. However, all these biochemical tools have their limitations, and these should be taken under consideration, along with the history, clinical features and imaging studies, when assessing patients for acromegaly.

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