Cellular Immune Responses of Peripheral Blood Mononuclear Cells to HBV Antigens during Chronic and Acute HBV Infection

Digestion ◽  
1992 ◽  
Vol 52 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Takaji Wakita ◽  
Shinichi Kakumu ◽  
Kentaro Yoshioka ◽  
Tetsuya Ishikawa ◽  
Yuji Ito ◽  
...  
2013 ◽  
Vol 34 (6) ◽  
pp. e80-e88 ◽  
Author(s):  
María C. Roque-Cuéllar ◽  
Berta Sánchez ◽  
José R. García-Lozano ◽  
Juan M. Praena-Fernández ◽  
José L. Márquez-Galán ◽  
...  

2011 ◽  
Vol 18 (10) ◽  
pp. 1765-1769 ◽  
Author(s):  
Maria Zilma Andrade Rodrigues ◽  
Maria Fernanda Rios Grassi ◽  
Sanjay Mehta ◽  
Xing-Quan Zhang ◽  
Luana Leandro Gois ◽  
...  

ABSTRACTTo evaluate the effects of HIV on immune responses in cutaneous leishmaniasis (CL), we quantified cytokine levels from plasma and stimulated peripheral blood mononuclear cells (PBMCs) from individuals infected with HIV and/or CL. Gamma interferon (IFN-γ) and interleukin 13 (IL-13) levels and the ratio of IFN-γ to IL-10 produced in response to stimulation with solubleLeishmaniaantigens were significantly lower in HIV-Leishmania-coinfected patients than in CL-monoinfected patients.


Author(s):  
Suji Kim ◽  
Hyun-Eui Park ◽  
Woo Bin Park ◽  
Seo Yihl Kim ◽  
Hong-Tae Park ◽  
...  

Mycobacterium avium, an opportunistic intracellular pathogen, is a member of the non-tuberculous mycobacteria species. M. avium causes respiratory disease in immunosuppressed individuals and a wide range of animals, including companion dogs and cats. In particular, the number of infected companion dogs has increased, although the underlying mechanism of M. avium pathogenesis in dogs has not been studied. Therefore, in the present study, the host immune response against M. avium in dogs was investigated by transcriptome analysis of canine peripheral blood mononuclear cells. M. avium was shown to induce different immune responses in canine peripheral blood mononuclear cells at different time points after infection. The expression of Th1-associated genes occurred early during M. avium infection, while that of Th17-associated genes increased after 12 h. In addition, the expression of apoptosis-related genes decreased and the abundance of intracellular M. avium increased in monocyte-derived macrophages after infection for 24 h. These results reveal the M. avium induces Th17 immune response and avoids apoptosis in infected canine cells. As the number of M. avium infection cases increases, the results of the present study will contribute to a better understanding of host immune responses to M. avium infection in companion dogs.


2012 ◽  
Vol 130 (1) ◽  
pp. 128e-137e ◽  
Author(s):  
Narayanan Nair ◽  
Sudheesh Pilakka-Kanthikeel ◽  
Zainulabedin Saiyed ◽  
Adriana Yndart ◽  
Madhavan Nair

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