Pancreatic Secretion of Zinc and Copper in Normal Subjects and in Patients with Chronic Pancreatitis

Digestion ◽  
1991 ◽  
Vol 49 (3) ◽  
pp. 161-166 ◽  
Author(s):  
I. Gjørup ◽  
L. Petronijevic ◽  
E. Rubinstein ◽  
B. Andersen ◽  
H. Worning ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Pancreatic Secretion ◽  
Normal Subjects

Dose-Response Relationships to Pancreozymin in Normal Subjects and Patients with Chronic Pancreatitis

1963 ◽  
Vol 45 (2) ◽  
pp. 209-214 ◽  
Author(s):  
Donald H. Hanscom ◽  
Armand Littman ◽  
Jack V. Pinto
Keyword(s):  
Chronic Pancreatitis ◽  
Dose Response ◽  
Normal Subjects

Correlation between Pancreatic Secretion of Bicarbonate and the Degree of Pancreatic Fibrosis in Patients with Early Morphological Changes of Chronic Pancreatitis

2017 ◽  
Vol 152 (5) ◽  
pp. S127
Author(s):  
Julio Iglesias-Garcia ◽  
Jose Lariño-Noia ◽  
Laura Nieto-Garcia ◽  
Santiago Lojo ◽  
J. Enrique Dominguez-Muñoz
Keyword(s):  
Chronic Pancreatitis ◽  
Pancreatic Secretion ◽  
Morphological Changes ◽  
Pancreatic Fibrosis

scholarly journals Role of the ducktal secretion dysfunction in the pathogenesis of chronic pancreatitis

2020 ◽  
Vol 17 (1) ◽  
pp. 122-128
Author(s):  
L. A. Mozheiko
Keyword(s):  
Chronic Pancreatitis ◽  
Rheological Properties ◽  
Pancreatic Secretion ◽  
Transport Mechanism ◽  
Early Stage ◽  
Fluid Secretion ◽  
Scientific Data ◽  
Ductal System ◽  
Stage Of Development

The review presents an analysis of current scientific data on the role of ductal secretion disorders in the pathogenesis of chronic pancreatitis. It is shown that under the influence of alcohol or other provoking factors, the CFTR transport mechanism of duct cells undergoes damage, which leads to the decrease in the bicarbonate and fluid secretion. Dehydration and acidification contribute to the hyperconcentration of protein and mucous components of pancreatic secretion and to the change in its rheological properties, which complicates further transport through the ductal system. Current conditions are favorable for the formation of mucoprotein plugs and the ductal obstruction that may have an important role in the pathogenesis of chronic pancreatitis at the early stage of development of the disease.

scholarly journals Functional characteristics of L1156F-CFTR associated with alcoholic chronic pancreatitis in Japanese

2015 ◽  
Vol 309 (4) ◽  
pp. G260-G269 ◽  
Author(s):  
Shiho Kondo ◽  
Kotoyo Fujiki ◽  
Shigeru B. H. Ko ◽  
Akiko Yamamoto ◽  
Miyuki Nakakuki ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Chronic Pancreatitis ◽  
Normal Subjects ◽  
Cftr Gene ◽  
Xenopus Laevis Oocytes ◽  
Transport Activity ◽  
Coding Region ◽  
Functional Characteristics ◽  
Alcoholic Chronic Pancreatitis ◽  
Exchange Activity

Although cystic fibrosis is rare in Japanese, measurement of sweat Cl− has suggested mild dysfunction of cystic fibrosis transmembrane conductance regulator (CFTR) in some patients with chronic pancreatitis. In the present study, we have investigated the association of CFTR variants and chronic pancreatitis in Japanese and the functional characteristics of a Japanese- and pancreatitis-specific CFTR variant, L1156F. Seventy patients with alcoholic chronic pancreatitis, 18 patients with idiopathic chronic pancreatitis, and 180 normal subjects participated. All exons and their boundaries and promoter region of the CFTR gene were sequenced. Human embryonic kidney-293 cells were transfected with three CFTR variants (M470V, L1156F, and M470V+L1156F), and the protein expression was examined. Xenopus laevis oocytes were injected with the CFTR variants, and bicarbonate (HCO3−) transport activity was examined. CFPAC-1 cells were transfected with the CFTR variants and Cl−/HCO3− exchange activity was examined. Six variants (E217G, I556V, M470V, L1156F, Q1352H, and R1453W) were identified in the coding region of the CFTR gene. Cystic fibrosis-causing mutations were not found. The allele frequencies of L1156F and Q1352H in alcoholic chronic pancreatitis (5.0 and 7.9%) were significantly ( P < 0.01) higher than those in normal subjects (0.6 and 1.9%). L1156F was linked with a worldwide CFTR variant, M470V. Combination of M470V and L1156F significantly reduced CFTR expression to ∼60%, impaired CFTR-mediated HCO3−/Cl− transport activity to 50–60%, and impaired CFTR-coupled Cl−/HCO3− exchange activity to 20–30%. The data suggest that the Japanese-specific CFTR variant L1156F causes mild dysfunction of CFTR and increases the risk of alcoholic chronic pancreatitis in Japanese.

Pancreatic Secretion of Bicarbonate in Patients with Chronic Pancreatitis

Digestion ◽  
1970 ◽  
Vol 3 (6) ◽  
pp. 350-356 ◽  
Author(s):  
Monique Vagne ◽  
L. Descos
Keyword(s):  
Chronic Pancreatitis ◽  
Pancreatic Secretion
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