Influence of CCK Antagonist L-364,718, Pancreastatin (33–49) and a Somatostatin Analogue on Camostate-induced Rat Pancreatic Hypertrophy

Digestion ◽  
1989 ◽  
Vol 44 (2) ◽  
pp. 105-116 ◽  
Author(s):  
Wolfgang E. Schmidt ◽  
Fritz Stöckmann ◽  
Anjona Roy Choudhury ◽  
Harald M. Wilms ◽  
Erhard G. Siegel ◽  
...  
1991 ◽  
Vol 10 (3) ◽  
pp. 179-182 ◽  
Author(s):  
S. Sundaram ◽  
A.D. Dayan

1 Raw soya flour (RSF) in the diet induces pancreatic hypertrophy and hyperplasia in the rat, changes ascribed to production of a high circulating level of cholecystokinin (CCK) due to inhibition of trypsin in the duodenum. Prolonged ingestion results in pancreatic adenomas and carcinomas. 2 L-364, 718, a potent, highly specific CCK antagonist was used to investigate the short-term role of CCK. 3 In rats fed 50% RSF and L-364, 718 5 mg kg-1 p.o. twice daily for 4 d, there was inhibition of pancreatic hypertrophy and hyperplasia, which is further evidence that peripherally-acting CCK plays a major role in the generation of RSF-mediated changes in the pancreas.


2016 ◽  
Author(s):  
Rana Ben Azzouna ◽  
Faisal Al-Shoukr ◽  
Fabien Hyafil ◽  
Francois Rouzet ◽  
Denis Guilloteau ◽  
...  

2017 ◽  
Author(s):  
İlknur Ozturk Unsal ◽  
Erman Cakal ◽  
Mahmut Apaydın ◽  
Melia Karakose ◽  
Bekir Ucan ◽  
...  

Diabetes ◽  
1990 ◽  
Vol 39 (5) ◽  
pp. 639-642 ◽  
Author(s):  
T. Mitsukawa ◽  
J. Takemura ◽  
J. Asai ◽  
M. Nakazato ◽  
K. Kangawa ◽  
...  

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