Gallbladder Disease – Chronic Relapsing Pancreatitis – Diabetes Mellitus

Digestion ◽  
1953 ◽  
Vol 79 (5) ◽  
pp. 282-293
Author(s):  
Ernst Lyon
2018 ◽  
Vol 2 (1) ◽  
pp. 7 ◽  
Author(s):  
Ajay Chhabra ◽  
Suparna Grover ◽  
Anil Vij ◽  
Amrit Pal Singh

<p><strong>Background:</strong> Diabetes mellitus is a modern epidemic which leads to various complications over a period of time. Autonomic neuropathy is one such complication which may lead on to gallbladder dysmotility and gallbladder stones.</p><p><strong>Objectives:</strong> To determine the incidence of gallbladder disorders in patients of type 2 diabetes mellitus and to find out the incidence of autonomic dysfunction in type 2 diabetes mellitus and correlate it with presence of gall bladder disorders.</p><p><strong>Material and Methods:</strong> The present study was conducted in 50 cases of type 2 diabetes mellitus and 25 healthy age and sex matched normal individuals were taken as controls. The cases as well as the controls underwent ultrasonographic examination for gall bladder volume, wall thickness, intraluminal mass and contraction in response to fatty meal. Data thus collected was compared and analysed statistically by using students ‘t’ test and chi- square test.</p><p><strong>Results:</strong> Mean postprandial gallbladder volume was 20.56±8.87 cm<sup>3</sup> in diabetics with ANP with gallstones, 26.16±1.24 cm<sup>3</sup> in diabetics with ANP with dysmotility 13.0±6.26 cm<sup>3</sup> in diabetics with gallstones without ANP, 12.14±4.88 cm<sup>3</sup> in normal diabetics and 13.60±5.95 cm<sup>3</sup> in controls. The percentage contraction post fatty meal was calculated from these values and found to be 24.73±14.64% in diabetics with ANP with dysmotility, 26.38±17 .04% in diabetics with ANP with dysmotility, 43.48±8.45% in diabetics with gallstones without ANP, 56.84±9.02% in normal diabetics and 57 .64±9.92% in controls.</p><p><strong>Conclusion:</strong> Incidence of gallbladder disease is much higher in type 2 diabetics (40%) as compared to normal healthy adults (4%). It was concluded that diabetics with ANP had significantly impaired gallbladder emptying. Poor control of diabetes, hypercholesterolemia and diabetic autonomic neuropathy are important risk factors for the development of gallbladder disease.</p>


Author(s):  
Bandar Alshalawi ◽  
Abdullah Almuslam ◽  
Reem Alqahtani ◽  
Al-Hanuf Al-Bokhari ◽  
Wed Alnajjar ◽  
...  

Diabetes has been theorized to build the danger of gallbladder complaint in light of the perception that insulin resistance and obesity are related with gallbladder. We conducted this meta-analysis using a comprehensive search of MEDLINE, PubMed, EMBASE, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials till 15 January 2017 for prospective observational studies that assessed the relationship of the effects of diabetes mellitus on gallbladder. We identified 8 prospective studies that could be included in the meta-analysis which included 6,089,807 participants. The summary RR for diabetes patients was 1.42 (95% CI: 1.32–1.87, I2=99.4%, p<0.0001). Although heterogeneity in general was very high, there was no heterogeneity between the studies with longer duration of follow-up. There was no evidence of publication bias. Our study shows additional support for an increased risk of gallbladder disease between diabetes patients.


1996 ◽  
Vol 41 (11) ◽  
pp. 2222-2228 ◽  
Author(s):  
Bruce A. Chapman ◽  
Ian R. Wilson ◽  
Christopher M. Frampton ◽  
Richard J. Chisholm ◽  
Neil R. Stewart ◽  
...  

1971 ◽  
Vol 24 (10) ◽  
pp. 1281-1289 ◽  
Author(s):  
Jeanne M. Reid ◽  
Sandra D. Fullmer ◽  
Karen D. Pettigrew ◽  
Thomas A. Burch ◽  
Peter H. Bennett ◽  
...  

1998 ◽  
Vol 39 (5) ◽  
pp. 663-668 ◽  
Author(s):  
Harry N. Bawden ◽  
Aidan Stokes ◽  
Carol S. Camfield ◽  
Peter R. Camfield ◽  
Sonia Salisbury

Author(s):  
Bruce R. Pachter

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).


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