Metabolic Fate of Plasma Diamine Oxidase: Evidence of Isolated and Perfused Rat Liver Uptake

Digestion ◽  
1986 ◽  
Vol 34 (4) ◽  
pp. 243-250 ◽  
Author(s):  
Luciano D’Agostino ◽  
Carolina Ciacci ◽  
Gaetano Capuano ◽  
Bruno Daniele ◽  
Giuseppe D’Argenio ◽  
...  
Keyword(s):  
Rat Liver ◽  
Diamine Oxidase ◽  
Perfused Rat Liver ◽  
Metabolic Fate ◽  
Liver Uptake

The Metabolic Fate of N-Acetyl-d-[1-14C]galactosamine in Isolated Perfused Rat Liver

1977 ◽  
Vol 5 (2) ◽  
pp. 442-443
Author(s):  
ALAN D. MacNICOLL ◽  
FREDERICK S. WUSTEMAN ◽  
GILLIAN M. POWELL ◽  
C. GERALD CURTIS
Keyword(s):  
Rat Liver ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Metabolic Fate

Hepatic lipase-mediated hydrolysis versus liver uptake of HDL phospholipids and triacylglycerols by the perfused rat liver

1991 ◽  
Vol 1082 (2) ◽  
pp. 185-194 ◽  
Author(s):  
Pedro Marques-Vidal ◽  
Christine Azéma ◽  
Xavier Collet ◽  
Hugues Chap ◽  
Bertrand P. Perret
Keyword(s):  
Rat Liver ◽  
Hepatic Lipase ◽  
Perfused Rat Liver ◽  
Liver Uptake

scholarly journals Effect of Emeriamine, an Inhibitor of Fatty Acid Oxidation, on Metabolic Fate of a Geometrical Isomer of Linoleic Acid in Perfused Rat Liver.

1998 ◽  
Vol 44 (4) ◽  
pp. 525-535 ◽  
Author(s):  
Nobuhiro FUKUDA ◽  
Masanori FUKUI ◽  
Yasuko KAI ◽  
Anura P. JAYASOORIYA ◽  
Masanobu SAKONO ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Linoleic Acid ◽  
Fatty Acid Oxidation ◽  
Rat Liver ◽  
Geometrical Isomer ◽  
Acid Oxidation ◽  
Perfused Rat Liver ◽  
Metabolic Fate

Hepatic uptake and disposition of human polymeric IgA1 in perfused rat liver: evidence for incomplete biliary excretion and intrahepatic degradation

1985 ◽  
Vol 248 (4) ◽  
pp. G450-G455
Author(s):  
M. H. Finck ◽  
J. Reichen ◽  
J. M. Vierling ◽  
T. M. Kloppel ◽  
W. R. Brown
Keyword(s):  
Rat Liver ◽  
Biliary Excretion ◽  
Immunoglobulin A ◽  
Hepatic Metabolism ◽  
Hepatic Uptake ◽  
Secretory Component ◽  
Secretory Iga ◽  
Perfused Rat Liver ◽  
Liver Uptake ◽  
Single Pass

The hepatic uptake of polymeric immunoglobulin A (IgA) is mediated by secretory component; the resulting secretory IgA is excreted intact into bile. To define the hepatic metabolism of polymeric IgA, we quantitated the uptake and transport of human polymeric IgA1 after a single pass through the perfused rat liver. Uptake of polymeric IgA1 was compared with that of asialoorosomucoid, a glycoprotein whose uptake is mediated by the asialoglycoprotein receptor. Single-pass hepatic uptake of 125I-polymeric IgA1 and of 125I-asialoorosomucoid averaged 18.0 +/- 3.1% (SE) and 71.8 +/- 2.8%, respectively. The uptake of 125I-polymeric IgA1 was inhibited by excess unlabeled polymeric IgA1 but not by asialoorosomucoid. Only 13.0 +/- 1.6% of the 125I-polymeric IgA1 extracted by the liver was excreted into bile, whereas three-fourths was released into the hepatic venous effluent in degraded form. Thus, both the uptake and biliary excretion of polymeric IgA1 by the rat liver are inefficient processes. Polymeric IgA1 follows two distinct pathways after uptake by the liver: a small proportion is excreted intact into bile, while the majority is degraded and released back into the circulation.

scholarly journals Effect of Dietary Sesamin on Metabolic Fate of an Exogenous Linolelaidic Acid in Perfused Rat Liver.

1999 ◽  
Vol 45 (4) ◽  
pp. 437-448 ◽  
Author(s):  
Nobuhiro FUKUDA ◽  
Lei ZHANG ◽  
Masaki KODAMA ◽  
Masanobu SAKONO ◽  
Takashi IDE ◽  
...  
Keyword(s):  
Rat Liver ◽  
Perfused Rat Liver ◽  
Metabolic Fate

Liver Blood Flow as a Major Determinant of the Clearance of Recombinant Human Tissue-Type Plasminogen Activator

1992 ◽  
Vol 67 (01) ◽  
pp. 083-087 ◽  
Author(s):  
A de Boer ◽  
C Kluft ◽  
J M Kroon ◽  
F J Kasper ◽  
H C Schoemaker ◽  
...  
Keyword(s):  
Blood Flow ◽  
Rat Liver ◽  
Healthy Subjects ◽  
Liver Blood Flow ◽  
Major Determinant ◽  
Tissue Type ◽  
Perfused Rat Liver ◽  
Liver Model ◽  
Type Plasminogen Activator ◽  
Proportional Change

SummaryThe influence of changes in liver blood flow on the clearance of rt-PA was studied both in healthy subjects and in a perfused rat liver model. Liver blood flow in healthy subjects was documented indirectly by the clearance of indocyanine green (ICG). Exercise reduced liver blood flow on average by 57% with a 95% confidence interval (95% Cl) ranging from 51% to 62% (n = 5) and increased plasma levels of rt-PA activity (after an i. v. infusion of 18 mg of rt-PA over 120 min) by 119% (95% Cl, 58% - 203%) and rt-PA antigen by 91% (95% Cl, 30% - 140%). In the perfused rat liver model it was shown that halving or doubling of the physiological flow rate of a perfusate, containing rt-PA caused a proportional change in the clearance of rt-PA, while the extraction of rt-PA by the liver remained similar. In conclusion, liver blood flow is a major determinant of the clearance of rt-PA. This may have important implications for dosage of rt-PA in patients with myocardial infarction.

A Comparison of Plasminogen Activators Derived from Rat Plasma, Primary Rat Hepatocytes and Isolated Perfused Rat Liver

1982 ◽  
Vol 47 (02) ◽  
pp. 166-172 ◽  
Author(s):  
Yoav Sharoni ◽  
Maria C Topal ◽  
Patricia R Tuttle ◽  
Henry Berger
Keyword(s):  
Rat Liver ◽  
Isoelectric Point ◽  
Rat Hepatocytes ◽  
Cell Types ◽  
Plasminogen Activators ◽  
Rat Plasma ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Molecular Weights ◽  
Physiological Relevance

SummaryOf the two cell types it was possible to culture from the dissociated rat liver, hepatocytes and Kupffer cells, only the former were fibrinolytically active. Rat hepatocytes during the first 24 hr in culture secreted two plasminogen activators with molecular weights identical to those found in rat plasma, an 80,000-dalton form (PA-80) and a 45,000-dalton form (PA-45). Partially purified preparations of plasminogen activators from both sources were subjected to isoelectric focusing (IEF) to compare characteristics further. There were three distinct peaks of PA-45 in each preparation with isoelectric points of 7.1, 7.2 and 7.4; all electrophoretic forms had the same low affinity to fibrin. PA-80 from both sources displayed similar IEF profiles with forms ranging from pH values of 7 to 8, all with the same high affinity to fibrin. The major form of PA-80 in the plasma preparation had an isoelectric point of 7.9 whereas that in the hepatocyte preparation had an isoelectric point of 7.6. The isolated perfused rat liver was also shown to produce both PA-80 and PA-45 emphasizing the physiological relevance of the findings with hepatocytes. It is concluded that in the rat hepatocytes contribute to the plasma profile with regard to the plasminogen activator content.

Troxerutin protects the isolated perfused rat liver from a possible lipid peroxidation by coumarin

Phytomedicine ◽  
2005 ◽  
Vol 12 (1-2) ◽  
pp. 52-61 ◽  
Author(s):  
B.S. Adam ◽  
R. Pentz ◽  
C.P. Siegers ◽  
O. Strubelt ◽  
M. Tegtmeier
Keyword(s):  
Lipid Peroxidation ◽  
Rat Liver ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver
Sign in / Sign up

Export Citation Format

Share Document