Long-Term Intracerebroventricular Infusion of Insulin, but Not Glucose, Modulates Body Weight and Hepatic Insulin Sensitivity by Modifying the Hypothalamic Insulin Signaling Pathway in Type 2 Diabetic Rats

2009 ◽  
Vol 89 (4) ◽  
pp. 387-399 ◽  
Author(s):  
Sunmin Park ◽  
Sang Mee Hong ◽  
Il Sung Ahn
Keyword(s):  
Body Weight ◽  
Insulin Sensitivity ◽  
Signaling Pathway ◽  
Insulin Signaling ◽  
Diabetic Rats ◽  
Hepatic Insulin Sensitivity ◽  
Intracerebroventricular Infusion ◽  
Type 2 Diabetic

Long-Term Oral L-Arginine Administration Improves Peripheral and Hepatic Insulin Sensitivity in Type 2 Diabetic Patients

Diabetes Care ◽  
2001 ◽  
Vol 24 (5) ◽  
pp. 875-880 ◽  
Author(s):  
P. Piatti ◽  
L. D. Monti ◽  
G. Valsecchi ◽  
F. Magni ◽  
E. Setola ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Hepatic Insulin Sensitivity ◽  
Type 2 Diabetic

Duodenal-jejunal exclusion improves insulin resistance in type 2 diabetic rats by upregulating the hepatic insulin signaling pathway

Nutrition ◽  
2015 ◽  
Vol 31 (5) ◽  
pp. 733-739 ◽  
Author(s):  
Ze-Qiang Ren ◽  
Peng-Bo Zhang ◽  
Xiu-Zhong Zhang ◽  
Shou-Kun Chen ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Signaling Pathway ◽  
Insulin Signaling ◽  
Diabetic Rats ◽  
Insulin Signaling Pathway ◽  
Hepatic Insulin Signaling ◽  
Type 2 Diabetic

Beneficial effect of galanin on insulin sensitivity in muscle of type 2 diabetic rats

2011 ◽  
Vol 103 (3-4) ◽  
pp. 284-289 ◽  
Author(s):  
Biao He ◽  
Mingyi Shi ◽  
Ling Zhang ◽  
Guangzhi Li ◽  
Lingxiang Zhang ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Beneficial Effect ◽  
Diabetic Rats ◽  
Type 2 Diabetic

GW24-e2332 Berberine alleviates mesenteric artery endothelial dysfunction by improving insulin sensitivity in type 2 diabetic rats

Heart ◽  
2013 ◽  
Vol 99 (Suppl 3) ◽  
pp. A100.3-A101 ◽  
Author(s):  
Ling Dong ◽  
Feng-Hao Geng ◽  
Zhao Zhang ◽  
Peng Zhang ◽  
Wen-Juan Xing ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Endothelial Dysfunction ◽  
Mesenteric Artery ◽  
Diabetic Rats ◽  
Type 2 Diabetic

scholarly journals Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF-β Signaling Pathway Activation in Type 2 Diabetic Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Biyu Hou ◽  
Yuerong Zhao ◽  
Guifen Qiang ◽  
Xiuying Yang ◽  
Chunyang Xu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Liver Injury ◽  
Signaling Pathway ◽  
Hepatic Steatosis ◽  
Diabetic Rats ◽  
Lipid Metabolism Disorder ◽  
Smad Signaling ◽  
Metabolism Disorder ◽  
Type 2 Diabetic

Lipid metabolism disorder and inflammation are essential promoters in pathogenesis of liver injury in type 2 diabetes. Puerarin (PUR) has been reported to exert beneficial effects on many diabetic cardiovascular diseases and chemical-induced liver injuries, but its effects on diabetic liver injury and its mechanism are still unclear. The current study was designed to explore the therapeutic effect and mechanism of PUR on liver injury in a type 2 diabetic rat model induced by a high-fat diet combined with low-dose streptozotocin. The diabetic rats were treated with or without PUR (100 mg/kg/day) by gavaging for 8 weeks, and biochemical and histological changes in liver were examined. Results showed that treatment with PUR significantly attenuated hepatic steatosis by regulating blood glucose and ameliorating lipid metabolism disorder. Liver fibrosis was relieved by PUR treatment. PUR inhibited oxidative stress and inflammation which was associated with inactivation of NF-κB signaling, thereby blocking the upregulation of proinflammatory cytokines (IL-1β, TNF-α) and chemokine (MCP-1). This protection of PUR on diabetic liver injury is possibly related with inhibition on TGF-β/Smad signaling. In conclusion, the present study provides evidence that PUR attenuated type 2 diabetic liver injury by inhibiting NF-κB-driven liver inflammation and the TGF-β/Smad signaling pathway.

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