Dementia with Lewy Bodies: Clinical Diagnosis and Therapeutic Approach

2009 ◽  
pp. 107-113 ◽  
Author(s):  
Gabriel Gold
Keyword(s):  
Clinical Diagnosis ◽  
Therapeutic Approach ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies

640 Consensus criteria for the clinical diagnosis of dementia with Lewy bodies (DLB)

1996 ◽  
Vol 17 (4) ◽  
pp. S159
Author(s):  
I.G. McKeith ◽  
R.H. Perry ◽  
E.K. Perry ◽  
P.G. Ince
Keyword(s):  
Clinical Diagnosis ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Diagnosis Of Dementia

Clinical Diagnosis of Dementia With Lewy Bodies

2005 ◽  
pp. 361-373 ◽  
Author(s):  
David J. Burn ◽  
Urs P. Mosimann ◽  
Ian G. McKeith
Keyword(s):  
Clinical Diagnosis ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Diagnosis Of Dementia

Accuracy of clinical diagnosis of dementia with Lewy bodies: a systematic review and meta-analysis

2017 ◽  
Vol 89 (4) ◽  
pp. 358-366 ◽  
Author(s):  
Giovanni Rizzo ◽  
Simona Arcuti ◽  
Massimiliano Copetti ◽  
Maria Alessandria ◽  
Rodolfo Savica ◽  
...  
Keyword(s):  
Systematic Review ◽  
Diagnostic Criteria ◽  
Clinical Diagnosis ◽  
Dementia With Lewy Bodies ◽  
Meta Analysis ◽  
Lewy Bodies ◽  
Diagnosis Of Dementia ◽  
Sensitivity Specificity ◽  
Late Stages ◽  
Over Time

BackgroundThe diagnosis of dementia with Lewy bodies (DLB) is based on diagnostic clinical criteria, which were updated over the years.ObjectiveTo evaluate, through a systematic review, accuracy of the diagnostic criteria, testing a possible improvement over time.MethodsWe searched on MEDLINE and SCOPUS databases for studies reporting diagnostic parameters regarding the clinical diagnosis of DLB until October 2016. We performed meta-analysis, using a Bayesian approach, on those using pathological examination as gold standard, subclassified based on the different diagnostic criteria used.ResultsWe selected 22 studies on 1585 patients. Pooled sensitivity, specificity and accuracy were 60.2%, 93.8%, 79.7%, respectively, for criteria antecedents to McKeith 1996. For McKeith 1996-possible, pooled sensitivity, specificity and accuracy were 65.6%, 80.6%, 77.9% in early stages and 72.3%, 64.3%, 66% in late stages, respectively. For McKeith 1996-probable, pooled sensitivity, specificity and accuracy were 19.4%, 95.1%, 77.7% in early stages and 48.6%, 88%, 79.2% in late stages, respectively. McKeith criteria 2005 were evaluated only in late stages: pooled sensitivity, specificity and accuracy were 91.3%, 66.7% and 81.6%, respectively, for possible diagnosis (only one study) and 88.3%, 80.8%, 90.7% for probable diagnosis, decreasing to 85.6%, 77.1% and 81.7% if only considering clinical settings focused on dementia diagnosis and care.Conclusions and relevanceDiagnostic criteria have become more sensitive and less specific over time, without substantial change in the accuracy. Based on current data, about 20% of DLB diagnosis are incorrect. Future studies are needed to evaluate if the recently released revised consensus criteria will improve the diagnostic accuracy of DLB.

Frontotemporal dementia and dementia with Lewy bodies in a case-control study of Alzheimer's disease

2009 ◽  
Vol 21 (4) ◽  
pp. 688-695 ◽  
Author(s):  
Olivier Piguet ◽  
Glenda M. Halliday ◽  
Helen Creasey ◽  
G. Anthony Broe ◽  
Jillian J. Kril
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Clinical Diagnosis ◽  
Dementia With Lewy Bodies ◽  
Case Control Study ◽  
Lewy Bodies ◽  
Case Control ◽  
Dementia Syndrome ◽  
Control Study

ABSTRACTBackground: The clinical presentations in dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) overlap considerably with that of Alzheimer's disease (AD) despite different pathological processes. Autopsy studies have also shown that multiple brain pathology occurs frequently, even in cases with a single clinical diagnosis. We aimed to determine the frequency of clinical diagnosis of FTD and DLB and the underlying pathology in a well-characterized cohort of patients with a clinical diagnosis of probable or possible AD.Methods: We conducted a retrospective analysis of 170 AD patients (probable AD = 83; possible AD = 87) originally enrolled in a case-control study, 27 with postmortem examination, to establish the number of cases meeting probable diagnosis for FTD and DLB, using a checklist of features compiled from their consensus criteria.Results: 23/83 probable AD cases and 32/87 possible AD cases met probable criteria for another dementia, more commonly DLB than FTD. AD pathology was present in 8/15 probable AD and 8/12 possible AD cases coming to autopsy. DLB pathology was seen in four cases and FTD pathology in eight cases. In the AD cases reaching clinical diagnosis for a second dementia syndrome and coming to autopsy, a minority showed non-AD pathology only.Conclusions: Presence of core clinical features of non-AD dementia syndromes is common in AD. Concordance between clinical and pathological diagnoses of dementia remains variable. We propose that repeat clinical examinations and structural neuroimaging will improve diagnostic accuracy. In addition, clinical diagnostic criteria for the main dementia syndromes require refinement.

scholarly journals Accuracy of Clinical Diagnosis of Dementia with Lewy Bodies versus Neuropathology

2017 ◽  
Vol 59 (4) ◽  
pp. 1139-1152 ◽  
Author(s):  
Ragnhild Skogseth ◽  
Tibor Hortobágyi ◽  
Hogne Soennesyn ◽  
Luiza Chwiszczuk ◽  
Dominic Ffytche ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Diagnosis Of Dementia

Three years survival in patients with a clinical diagnosis of dementia with Lewy bodies

2000 ◽  
Vol 15 (3) ◽  
pp. 267-273 ◽  
Author(s):  
Zuzana Walker ◽  
Ruth L. Allen ◽  
Sukhwinder Shergill ◽  
Eleanor Mullan ◽  
Cornelius L. E. Katona
Keyword(s):  
Clinical Diagnosis ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Diagnosis Of Dementia
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