Methacholine-lnduced Histamine Liberation during Airway Challenge Tests in Ascaris Skin-Sensitive Sheep

Respiration ◽  
1995 ◽  
Vol 62 (6) ◽  
pp. 322-330
Author(s):  
W. Marek ◽  
W.T. Ulmer
Keyword(s):  
Histamine Liberation ◽  
Challenge Tests

Serotonin und Persönlichkeit

2000 ◽  
Vol 21 (3) ◽  
pp. 226-234 ◽  
Author(s):  
Jürgen Hennig
Keyword(s):  
Challenge Tests ◽  
Diagnostische Methoden

Zusammenfassung: Es werden kurz drei wichtige Persönlichkeitstheorien vorgestellt, die die Beteiligung des serotonergen Neurotransmittersystems an der Ausprägung dispositioneller Merkmale auf der Ebene von Temperamentseigenschaften konstatieren. Der vorliegende Beitrag fasst die zentralen Befunde zusammen. Zunächst wird jedoch beschrieben, über welche Charakteristika das serotonerge Neurotransmittersystem verfügt, und welche Schwierigkeiten sich hinsichtlich der Messung von Indikatoren serotonerger Aktivität bzw. Ansprechbarkeit ergeben. Basierend auf einigen ausgewählten Befunden aus dem Bereich der biologischen Psychiatrie wird dann dargestellt, dass sich serotonerge Auffälligkeiten klinischer Populationen durchaus in den Bereich der gesunden Persönlichkeit übertragen lassen. Konkreter wird gezeigt, dass sich Personen mit erhöhter Ausprägung auf den Dimensionen Depressivität, Aggressivität und Impulsivität über eine geringe Ansprechbarkeit des serotonergen Systems im Zuge des so genannten Neurotransmitter-Challenge-Tests charakterisieren lassen. Implikationen für ein Verständnis der zugrundeliegenden Mechanismen interindividueller Differenzen und Implikationen für ggfs. veränderte diagnostische Methoden werden diskutiert.

Aripiprazole has both agonistic and antagonistic effects on the dopaminergic system in endocrinological challenge tests

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
C Schüle ◽  
AK Schmidt ◽  
TC Baghai ◽  
D Eser ◽  
S Wenninger ◽  
...  
Keyword(s):  
Dopaminergic System ◽  
Antagonistic Effects ◽  
Challenge Tests

ДИАГНОСТИКА ХРОНИЧЕСКИХ ИНДУЦИРОВАННЫХ КРАПИВНИЦ

2019 ◽  
pp. 5-13
Author(s):  
E.Yu. Borzova
Keyword(s):  
Quality Of Life ◽  
Biological Therapy ◽  
Treatment Algorithm ◽  
The Novel ◽  
International Guidelines ◽  
Systemic Reactions ◽  
Significant Impairment ◽  
Challenge Tests

Хронические индуцированные крапивницы имеют важное социальноэкономическое значение вследствие риска развития системных реакций и значительного снижения качества жизни пациентов. Диагностика хронических индуцированных крапивниц основывается на анамнестических данных и проведении провокационных тестов. Современный протокол ведения больных хронической крапивницей включает применение неседативных антигистаминных препаратов. Международные согласительные документы по лечению крапивницы рекомендуют 4кратное увеличение суточной дозы неседативных антигистаминных препаратов при их неэффективности в стандартных дозах. Данные метаанализа указывают на эффективность омализумаба при хронических индуцированных крапивницах. В перспективе ожидается расширение арсенала генноинженерной биологической терапии хронических индуцированных крапивниц.Chronic inducible urticarias are characterized by the risks of systemic reactions and a significant impairment of patients quality of life. The diagnosis of chronic inducible urticarias relies on the patients history and the challenge tests. A treatment algorithm for the management of chronic inducible urticarias includes nonsedating antihistamines as a firstline treatment. The international guidelines for the management of chronic inducible urticarias recommend updosing of nonsedating antihistamines up to four fold if standard doses are not effective. The metaanalysis suggests the efficacy of omalizumab in chronic inducible urticarias. In the prospect, the novel options of biological therapy for chronic inducible urticarias are expected.

ДИАГНОСТИКА ХРОНИЧЕСКИХ ИНДУЦИРОВАННЫХ КРАПИВНИЦ

2019 ◽  
Author(s):  
E.Yu. Borzova
Keyword(s):  
Biological Therapy ◽  
Meta Analysis ◽  
Treatment Algorithm ◽  
The Novel ◽  
First Line ◽  
Systemic Reactions ◽  
Significant Impairment ◽  
Challenge Tests ◽  
First Line Treatment

Хронические индуцированные крапивницы имеют важное социально-экономическое значение вследствие риска развития системных реакций и значительного снижения качества жизни пациентов. Диагностика хронических индуцированных крапивниц основывается на анамнестических данных и проведении провокационных тестов. Современный протокол ведения больных хронической крапивницей включает применение неседативных антигистаминных препаратов. Международные согласительные документы по лечению крапивницы рекомендуют 4-кратное увеличение суточной дозы неседативных антигистаминных препаратов при их неэффективности в стандартных дозах. Данные мета-анализа указывают на эффективность омализумаба при хронических индуцированных крапивницах. В перспективе ожидается расширение арсенала генно-инженерной биологической терапии хронических индуцированных крапивниц.Chronic inducible urticarias are characterized by the risks of systemic reactions and a significant impairment of patients quality of life. The diagnosis of chronic inducible urticarias relies on the patients history and the challenge tests. A treatment algorithm for the management of chronic inducible urticarias includes nonsedating antihistamines as a first-line treatment. The international guidelines for the management of chronic inducible urticarias recommend updosing of nonsedating antihistamines up to four fold if standard doses are not effective. The meta-analysis suggests the efficacy of omalizumab in chronic inducible urticarias. In the prospect, the novel options of biological therapy for chronic inducible urticarias are expected.

scholarly journals Measuring phenotypic flexibility by transcriptome time‐course analyses during challenge tests before and after energy restriction

2019 ◽  
Vol 33 (9) ◽  
pp. 10280-10290 ◽  
Author(s):  
Inge P. G. Bussel ◽  
Parastoo Fazelzadeh ◽  
Gary S. Frost ◽  
Milena Rundle ◽  
Lydia A. Afman
Keyword(s):  
Time Course ◽  
Energy Restriction ◽  
Phenotypic Flexibility ◽  
Before And After ◽  
Challenge Tests

scholarly journals Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 102
Author(s):  
Magda Babina ◽  
Zhao Wang ◽  
Kristin Franke ◽  
Torsten Zuberbier
Keyword(s):  
Mast Cells ◽  
Priming Effect ◽  
Skin Diseases ◽  
Thymic Stromal Lymphopoietin ◽  
Dependent Manner ◽  
Atopic Diseases ◽  
Time Points ◽  
Histamine Liberation ◽  
Atopic Skin ◽  
Th2 Immunity

Thymic stromal lymphopoietin (TSLP) is released by epithelial cells following disturbed homeostasis to act as “alarmin” and driver of Th2-immunity. Aberrant TSLP expression is a hallmark of atopic diseases, including atopic dermatitis (AD). Mast cells (MCs) are overabundant in AD lesions and show signs of degranulation, but it remains unknown whether TSLP contributes to granule discharge. Degranulation of skin MCs proceeds via two major routes, i.e., FcεRI-dependent (allergic) and MRGPRX2-mediated (pseudo-allergic/neurogenic). Evidence is accumulating that MRGPRX2 may be crucial in the context of skin diseases, including eczema. The current study reveals TSLP as a novel priming factor of human skin MCs. Interestingly, TSLP selectively cooperates with MRGPRX2 to support granule discharge, while it does not impact spontaneous or FcεRI-driven exocytosis. TSLP-assisted histamine liberation triggered by compound 48/80 or Substance P, two canonical MRGPRX2 agonists, was accompanied by an increase in CD107a+ cells (a MC activation marker). The latter process was less potent, however, and detectable only at the later of two time points, suggesting TSLP may prolong opening of the granules. Mechanistically, TSLP elicited phosphorylation of STAT5 and JNK in skin MCs and the reinforced degranulation critically depended on STAT5 activity, while JNK had a contributory role. Results from pharmacological inhibition were confirmed by RNA-interference, whereby silencing of STAT5 completely abolished the priming effect of TSLP on MRGPRX2-mediated degranulation. Collectively, TSLP is the first factor to favor MRGPRX2- over FcεRI-triggered MC activation. The relevance of TSLP, MCs and MRGPRX2 to pruritis and atopic skin pathology indicates broad repercussions of the identified connection.

scholarly journals Microfabricated potentiometric sensor for personalized methacholine challenge tests during the COVID-19 pandemic

2021 ◽  
pp. 113439
Author(s):  
Norhan Badr ElDin ◽  
Mohamed K. Abd El-Rahman ◽  
Hala E. Zaazaa ◽  
Azza A. Moustafa ◽  
Said A. Hassan
Keyword(s):  
Potentiometric Sensor ◽  
Methacholine Challenge ◽  
Challenge Tests
Sign in / Sign up

Export Citation Format

Share Document